The critical zeta potential of polymer membranes: how electrolytes impact membrane fouling

Breite, Daniel; Went, Marco; Prager, Andrea; Schulze, Agnes

doi:10.1039/c6ra19239d

Cited by 52 publications

(33 citation statements)

References 50 publications

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“…In theory, similarly charged colloids beyond the critical zeta potential (magnitude of~10 mV) are repulsive and reduce filter cake formation desirable (Breite, Went, Prager, & Schulze, 2016;Cai et al, 2016).…”

Section: Impact Of General and Physicochemical Membrane Properties mentioning

confidence: 99%

“…It should be noted that the zeta potential of the membranes was measured at lower salt concentrations, while the filtration was done under broth conditions with high salinity. It can be assumed that the streaming potential during filtration was lower than measured but values appear to correlate to the zeta potential of the culture broth (Breite et al, 2016;Schäfer, Pihlajamäki, Fane, Waite, & Nyström, 2004).…”

Section: Impact Of General and Physicochemical Membrane Properties mentioning

confidence: 99%

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Virus harvesting in perfusion culture: Choosing the right type of hollow fiber membrane

Nikolay

Grooth

Genzel

et al. 2020

Biotech & Bioengineering

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The use of bioreactors coupled to membrane‐based perfusion systems enables very high cell and product concentrations in vaccine and viral vector manufacturing. Many virus particles, however, are not stable and either lose their infectivity or physically degrade resulting in significant product losses if not harvested continuously. Even hollow fiber membranes with a nominal pore size of 0.2 µm can retain much smaller virions within a bioreactor. Here, we report on a systematic study to characterize structural and physicochemical membrane properties with respect to filter fouling and harvesting of yellow fever virus (YFV; ~50 nm). In tangential flow filtration perfusion experiments, we observed that YFV retention was only marginally determined by nominal but by effective pore sizes depending on filter fouling. Evaluation of scanning electron microscope images indicated that filter fouling can be reduced significantly by choosing membranes with (i) a flat inner surface (low boundary layer thickness), (ii) a smooth material structure (reduced deposition), (iii) a high porosity (high transmembrane flux), (iv) a distinct pore size distribution (well‐defined pore selectivity), and (v) an increased fiber wall thickness (larger effective surface area). Lowest filter fouling was observed with polysulfone (PS) membranes. While the use of a small‐pore PS membrane (0.08 µm) allowed to fully retain YFV within the bioreactor, continuous product harvesting was achieved with the large‐pore PS membrane (0.34 µm). Due to the low protein rejection of the latter, this membrane type could also be of interest for other applications, that is, recombinant protein production in perfusion cultures.

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Section: Impact Of General and Physicochemical Membrane Properties mentioning

confidence: 99%

Section: Impact Of General and Physicochemical Membrane Properties mentioning

confidence: 99%

Virus harvesting in perfusion culture: Choosing the right type of hollow fiber membrane

Nikolay

Grooth

Genzel

et al. 2020

Biotech & Bioengineering

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“…The reference membrane was only composed of PES and thus, exhibits a hydrophobic surface with a WCA of 89 • (ATR-IR measurements confirmed the absence of PEG from the membrane preparation. These results are not discussed here, as this type of membrane was used in prior publications [14,44,45].) The dense PA layer of the PES-PA membrane resulted in a significantly more hydrophilic surface with a WCA of 59 • .…”

Section: Membrane Modification With Amide Fuctionalitiesmentioning

confidence: 99%

Reduction of Biofouling of a Microfiltration Membrane Using Amide Functionalities—Hydrophilization without Changes in Morphology

et al. 2020

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A major goal of membrane science is the improvement of the membrane performance and the reduction of fouling effects, which occur during most aqueous filtration applications. Increasing the surface hydrophilicity can improve the membrane performance (in case of aqueous media) and decelerates membrane fouling. In this study, a PES microfiltration membrane (14,600 L m−2 h−1 bar−1) was hydrophilized using a hydrophilic surface coating based on amide functionalities, converting the hydrophobic membrane surface (water contact angle, WCA: ~90°) into an extremely hydrophilic one (WCA: ~30°). The amide layer was created by first immobilizing piperazine to the membrane surface via electron beam irradiation. Subsequently, a reaction with 1,3,5-benzenetricarbonyl trichloride (TMC) was applied to generate an amide structure. The presented approach resulted in a hydrophilic membrane surface, while maintaining permeance of the membrane without pore blocking. All membranes were investigated regarding their permeance, porosity, average pore size, morphology (SEM), chemical composition (XPS), and wettability. Soxhlet extraction was carried out to demonstrate the stability of the applied coating. The improvement of the modified membranes was demonstrated using dead-end filtration of algae solutions. After three fouling cycles, about 60% of the initial permeance remain for the modified membranes, while only ~25% remain for the reference.

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“…This electrical potential occurs due to the presence of electronegative charges located in the skin layer of the membrane . Membrane fouling may occur as a result of this electrical gradient and thus reduce dialyzer performance …”

Section: Membrane Manufacturing and Processingmentioning

confidence: 99%

“…49 Membrane fouling may occur as a result of this electrical gradient and thus reduce dialyzer performance. 50 Dialyzers are checked to ensure that the capillary fibers are intact and will not leak blood. If a leak is found, manufacturers may either discard the dialyzer or attempt a by sealing the damaged fibers with potting material.…”

Section: Membrane Manufacturing and Processingmentioning

confidence: 99%

Choosing a dialyzer: What clinicians need to know

Haroon¹,

Davenport

2018

Hemodialysis International

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The objectives of hemodialysis have moved from the diffusive clearance of small molecular weight uremic toxins and achieving dialyzer urea adequacy targets to emphasis on improving clinical outcomes in end stage renal failure patients by increasing larger sized uremic toxin clearance. Clinical emphasis in the last few decades has focused on increasing middle molecule weight toxin clearance by hemodiafiltration. Although long‐term data is still lacking, short‐term outcomes appear promising. Advancements in nanotechnology have now introduction a new generation of medium cut‐off membrane dialyzers which allow diffusive clearance of similar middle molecular weight uremia toxin clearance as hemodiafiltration, without increased albumin losses. As these dialyzers have only recently been introduced into clinical practice, no long‐term outcomes are available to determine the relative benefits or advantages of this approach. As dialyzers are now designed to maximize diffusive or convective clearance, or provide a combination, then clinicians can now choose dialyzers tailored to the individual patient needs depending on clinical circumstances. We review the key important features in choosing a dialyzer for patients with end stage renal failure and acute kidney injury.

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The critical zeta potential of polymer membranes: how electrolytes impact membrane fouling

Abstract: The zeta potential of membrane surfaces and the resulting electrostatic interactions are determining factors of membrane fouling. This publication presents the impact of salt concentration and pH value on these interactions.

Cited by 52 publications

References 50 publications

Virus harvesting in perfusion culture: Choosing the right type of hollow fiber membrane

Virus harvesting in perfusion culture: Choosing the right type of hollow fiber membrane

Reduction of Biofouling of a Microfiltration Membrane Using Amide Functionalities—Hydrophilization without Changes in Morphology

Choosing a dialyzer: What clinicians need to know

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