1937
DOI: 10.1042/bj0311837
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The coupling of oxido-reductions and dismutations with esterification of phosphate in muscle

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Cited by 104 publications
(18 citation statements)
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“…The substance reduced is the pyridine nucleotide coenzyme I. The total reaction may be summarized (Needham & Pillai, 1937) thus: phosphoglyceraldehyde + phosphate + adenylic acid + coenzyme Î phosphoglyceric acid + adenyl phosphate + reduced coenzyme I. The mechanism of this reaction, or, in other words, the method of linking its oxidation of phosphoglyceraldehyde with its phosphorylation of adenylic acid, has been worked out by Warburg & Christian (1939) and by Negelein & Bromel (1939) The hydrolysis of the last stage has a decrease of free energy = 11 25 Cal.…”
Section: Utilization Of Energy In Chemical Reactionsmentioning
confidence: 99%
“…The substance reduced is the pyridine nucleotide coenzyme I. The total reaction may be summarized (Needham & Pillai, 1937) thus: phosphoglyceraldehyde + phosphate + adenylic acid + coenzyme Î phosphoglyceric acid + adenyl phosphate + reduced coenzyme I. The mechanism of this reaction, or, in other words, the method of linking its oxidation of phosphoglyceraldehyde with its phosphorylation of adenylic acid, has been worked out by Warburg & Christian (1939) and by Negelein & Bromel (1939) The hydrolysis of the last stage has a decrease of free energy = 11 25 Cal.…”
Section: Utilization Of Energy In Chemical Reactionsmentioning
confidence: 99%
“…Effect ofiodoacetate on thymidine uptake. Since thymidine uptake has been shown to be energydependent, the effect of iodoacetate, an inhibitor of glyceraldehyde-3-phosphate dehydrogenase, was investigated (17). The experiment presented in Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Clifton (1946) showed that 5x10^*' M dinitrophenol completely blocked synthetic reactions without interfering with oxidation, while Loomis and Lipmann (1948) found that dinitrophenol prevented phosphoryiation without affecting oxidation. Similarly, Needham and Pillai (1937) found that arsenate is able to substitute for inorganic phosphate in oxidative reactions for which inorganic phosphate uptake is otherwise necessary for ttie reaction to take place.…”
Section: Introductionmentioning
confidence: 92%