The cough suppressive activity of sulfated glucuronoxylan from Fagus sylvatica L.

Nosálóvá, G; Jurecek, Ludovit; Turjan, J.; Capek, Peter; Prisenžňáková, L.; Fraňová, Soňa

doi:10.1016/j.ijbiomac.2014.03.027

Cited by 5 publications

(9 citation statements)

References 25 publications

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“…In GXS3, the cross peaks at δ 4.70/100.2 and 4.67/101.1 were assigned to H1/C1 of partly substituted Xyl residues at positions O3 or O2, respectively. The cross peaks at δ 5.09/99.3 and 3.49/61.2 were assigned to H1/C1 of glucuronic acid and its 4‐ O ‐methyl group . It was found that under these conditions 4 O MeGlcA residues were not sulfated.…”

Section: Resultsmentioning

confidence: 93%

“…From the literature data, it is evident that antitussive activity can be expressed by several polysaccharide types, which vary in chemical structure, i.e ., in monosaccharide composition, content of neutral sugars and uronic acids, presence or absence of branches in their backbones, configuration of linkages, molecular mass, and in other structural details . The aim of this study was to clarify whether there is a relationship between the molecular mass and the antitussive activity of beech hemicelluloses.…”

Section: Resultsmentioning

confidence: 99%

“…In our previous study, we have found that glucuronoxylan sulfate (GXS1) in a dose 50 mg/kg b.w. showed a promising antitussive activity, i.e ., slightly lower than that of codeine, the strongest antitussive agent widely used in a clinical practice . The aim of this study was to verify whether the increased GXS1 dose increase its pharmacological effect and whether the molecular weight of glucuronoxylan sulfates (GXS2, GXS3, and GXS4) affect their pharmacodynamic properties.…”

Section: Resultsmentioning

confidence: 99%

“…The FT‐IR spectra of the native (GX1) and sulfated (GXS1) glucuronoxylans , as well as depolymerized glucuronoxylan sulfates (GXS2, GXS3, and GXS4) are presented in Fig. .…”

Section: Resultsmentioning

confidence: 99%

“…As an important part of cereals, xylan‐related polymers also exhibit probiotic and positive digestive, antidiabetic, and hypocholesterolemic effects . Lately, as well an antitussive activity of Fagus glucuronoxylan sulfate has been described .…”

Section: Introductionmentioning

confidence: 99%

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Fagus sylvatica glucuronoxylan sulfate−chemical profile and pharmacological view

et al. 2015

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Glucuronoxylans represent a large group of naturally occurring and renewable biopolymers with a wide range of application possibilities. Controlled depolymerization of Fagus sylvatica 4-Omethylglucuronoxylan afforded three fractions of descending molecular mass, i.e., 3000, 2600, and 1800 g/mol. The native polymer (GX1) and its depolymerized fractions (GX2, GX3, and GX4) were decorated by functional groups to give sulfated products (GXS1, GXS2, GXS3, and GXS4) which were used for pharmacological tests. Antitussive activity tests revealed that the increase in the dose of the glucuronoxylan sulfate (GXS1) from 50 to 100 mg/kg body weight resulted in only slightly increased cough-suppressing effect. This fact indicates that the cough-suppressing effect of the glucuronoxylan sulfate is not dose dependent. Results have shown significant coughsuppressing effect of GXS1, it was only slightly lower than the effect of narcotic codeine. Glucuronoxylan-derived fractions decorated by sulfates (GXS2, GXS3, and GXS4) showed similar cough-suppressing effect as the polymer-sulfate (GXS1) confirming thus that the changes in molecular mass does not affect the cough suppressive activity. Similarly, different contents of sulfate groups in GXS2, GXS3, and GXS4 did not influence their effect. Tests have shown that in the antitussive activity of all glucuronoxylan sulfates a bronchodilation was not involved. During the experiment course, no serious side effects after administration of glucuronoxylan sulfates were observed which is important fact from the application point of view.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…The FT‐IR spectra of the native (GX1) and sulfated (GXS1) glucuronoxylans , as well as depolymerized glucuronoxylan sulfates (GXS2, GXS3, and GXS4) are presented in Fig. .…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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