The Cost-Effectiveness of Low-Dose CT Screening for Lung Cancer*

Cost-Effectiveness of CT Screening in the National Lung Screening Trial

“…The ICER rose substantially when we included future health care costs of survivors that were unrelated to lung cancer, but we did not include these costs in our base case because their inclusion is controversial 12 and because they have not been included in prior cost-effectiveness analyses of lung-cancer screening. [7][8][9][10]31,33,35 The ICER also rose substantially when we increased the costs of the screening examination, follow-up, and surgery and when we reduced the quality of life related to positive screening results and to a diagnosis of stage IA lung cancer.…”

“…5 One major consideration for policymakers is the cost-effectiveness of this screening intervention. 6 Before publication of the NLST results, several cost-effectiveness analyses reported results ranging from very favorable 7,8 to unfavorable. 9,10 This variation reflected both the uncertainty regarding the effectiveness of screening with low-dose CT for lung cancer and the use of different methods of analysis.…”

The Inconclusive Evidence on CT Screening for Lung Cancer

“…Estimates of the cost-effectiveness of CT screening depend on assumptions such as the cost of the screening CT, the false-positive rate, the number and type of diagnostic tests and procedures and their costs, the stage distribution of cancers detected, treatment methods and costs, and mortality rates. Whereas previous studies found that the cost per quality-adjusted life year saved would be less than $50,000 (the amount at present generally accepted as the upper limit for being cost-effective) [27,28], studies using NLST data estimate substantially higher costs [29,30]. A pending cost-effectiveness analysis from the NLST, based on cost data collected from actual screening, should provide even more realistic estimates.…”

Az alacsony dózisú CT-vel végzett tüdőrákszűrés magyarországi egészség-gazdaságtani elemzésének koncepcionális terve

“…Az irodalomkutatás során 16 olyan költség-hatékonysági modellt találtunk a szakirodalomban, amely az alacsony dózisú CT-vel történő tüdőrákszűrést értékeli (1. táblá-zat) [8,11,[22][23][24][25][26][27][28][29][30][31][32][33][34][35]. Black és mtsai az NLST vizsgálat mentén készült értékelésükben az alacsony dózisú CTvel történő szűrést a szűrés elmaradásának alternatívájá-val, valamint a mellkasröntgennel való szűréssel is össze-vetették.…”