The Cost-effectiveness of Antimicrobial Lock Solutions for the Prevention of Central Line–Associated Bloodstream Infections

Pliakos, Elina Eleftheria; Andreatos, Nikolaos; Ziakas, Panayiotis D.; Mylonakis, Eleftherios

doi:10.1093/cid/ciy511

Cited by 15 publications

(17 citation statements)

References 35 publications

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“…Besides therapy for CVC-related infections, prophylactic ALT might decrease the incidence of central-line associated infections in cancer patients [159]. This approach seems promising and has demonstrated its cost-effectiveness specifically in cancer therapy [160], although further studies are warranted to optimize prophylactic ALT use. * Concentration should exceed 100-1000× minimal inhibitory concentration (MIC).…”

Section: Central Venous Catheter-related Infectionsmentioning

confidence: 99%

Risk Factors for Infections, Antibiotic Therapy, and Its Impact on Cancer Therapy Outcomes for Patients with Solid Tumors

Kubeček

Paterová

Novosadová

2021

Life

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Infections represent a significant cause of morbidity and mortality in cancer patients. Multiple factors related to the patient, tumor, and cancer therapy can affect the risk of infection in patients with solid tumors. A thorough understanding of such factors can aid in the identification of patients with substantial risk of infection, allowing medical practitioners to tailor therapy and apply prophylactic measures to avoid serious complications. The use of novel treatment modalities, including targeted therapy and immunotherapy, brings diagnostic and therapeutic challenges into the management of infections in cancer patients. A growing body of evidence suggests that antibiotic therapy can modulate both toxicity and antitumor response induced by chemotherapy, radiotherapy, and especially immunotherapy. This article provides a comprehensive review of potential risk factors for infections and therapeutic approaches for the most prevalent infections in patients with solid tumors, and discusses the potential effect of antibiotic therapy on toxicity and efficacy of cancer therapy.

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Section: Central Venous Catheter-related Infectionsmentioning

confidence: 99%

Risk Factors for Infections, Antibiotic Therapy, and Its Impact on Cancer Therapy Outcomes for Patients with Solid Tumors

Kubeček

Paterová

Novosadová

2021

Life

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“…The identification of bacteria in blood samples determines an important diagnostic resource in infectious diseases. Bloodstream Infections in hospital units most of the times may indicate a critical state of the patients, with high lethality rates, and with an increase in the hospitalization period and high costs per patient (Pliakos et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Microbiological characteristics of bloodstream infections in a reference hospital in northeastern Brazil

et al. 2024

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Routine blood culture is used for the detection of bloodstream infections by aerobic and anaerobic bacteria and by common pathogenic yeasts. A retrospective study was conducted in a public hospital in Maceió-AL, by collecting data of all medical records with positive blood cultures. Out of the 2,107 blood cultures performed, 17% were positive with Staphylococcus coagulase negative (51.14%), followed by Staphylococcus aureus (11.21%) and Klebsiella pneumoniae (6.32%). Gram-positive bacteria predominated among positive blood cultures, highlighting the group of Staphylococcus coagulase-negative. While Gram-negative bacteria had a higher number of species among positive blood cultures.

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“…The infection severity is increased by some factors, such as the immunocompromised state of the patient and the presence of bacteria strains with a multidrug-resistance profile [1,2,3,4]. The use of medical devices is also considered an important risk factor for the development of bloodstream infections that are the leading cause of death for hospitalized patients [5].…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic and Molecular Profile of Staphylococcus aureus Isolated from Bloodstream Infections in Northeast Brazil

Monteiro¹,

Pinto²,

Monteiro³

et al. 2019

Microorganisms

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Staphylococcus aureus is a notorious human pathogen associated with serious nosocomial and community-acquired infections, such as pneumonia, meningitis, endocarditis, toxic shock syndrome, and sepsis, among others. The objective of this study was to investigate the molecular profile, antimicrobial resistance, and clonal diversity of S. aureus isolated from the bloodstream. The determination of the minimum inhibitory concentration (MIC) of the antimicrobial was performed by an automated method. The presence of several virulence and resistance genes was evaluated by PCR. In addition, multilocus sequence typing (MLST) was used to analyze the clonal diversity of S. aureus. A high resistance to oxacillin (78%), clindamycin (78%), erythromycin (70%), ciprofloxacin (61%), and gentamicin (52%) was observed among the isolates. In most of them, the following virulence genes were detected: hlb (83%), ebpS (61%), icaA (57%), fnbpA (17%), and clfA (13%). Only one isolate carried the pvl gene. MLST analysis identified five new sequence types (STs): 5429, 5430, 5431, 5432, and 5433, as well as another seven—ST5, ST97, ST398, ST101, ST30, ST461, and ST2779—among the remaining strains. These seven STs and the four new STs are clustered in four clonal complexes: CC1, CC2, CC7, and CC17. Phylogenetic analysis showed the genetic relationship of the five new ST strains with another 18 strains. Altogether, these analyses indicate the horizontal transfer acquisition of virulence factor genes and multidrug resistance.

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The Cost-effectiveness of Antimicrobial Lock Solutions for the Prevention of Central Line–Associated Bloodstream Infections

Abstract: In three distinct and clinically important settings (hemodialysis, cancer treatment patients and home parenteral nutrition), antimicrobial lock solutions are an effective strategy for the prevention of CLABSI and their use can result in significant health-care savings.

Cited by 15 publications

References 35 publications

Risk Factors for Infections, Antibiotic Therapy, and Its Impact on Cancer Therapy Outcomes for Patients with Solid Tumors

Risk Factors for Infections, Antibiotic Therapy, and Its Impact on Cancer Therapy Outcomes for Patients with Solid Tumors

Microbiological characteristics of bloodstream infections in a reference hospital in northeastern Brazil

Phylogenetic and Molecular Profile of Staphylococcus aureus Isolated from Bloodstream Infections in Northeast Brazil

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