Microbiological characteristics of bloodstream infections in a reference hospital in northeastern Brazil

Melo, Maria Celeste Nunes de; Neto, Antônio de Pádua Medeiros de Carvalho; Maranhão, Tereza Lúcia Gomes Quirino; Junior, Enéas Costa; Nascimento, Cicera Maria Alencar do; Cavalcanti, Maria Taciana Holanda; Ferreira-Júnior, G. C.; Rocha, Mabel Alencar do Nascimento; Silva, K. M.; Júnior, Cláudio José dos Santos; Rocha, Thiago José Matos

doi:10.1590/1519-6984.253065

Cited by 4 publications

(6 citation statements)

References 13 publications

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“…A maioria dos casos não foi submetido à NPT e HDL, terapias invasivas apontadas na literatura como associadas ao aumento do potencial de risco de IPCSL relacionada à CVC nos pacientes em uso dessas terapêuticas (BRASIL, 2017). Um estudo que avaliou a efetividade e custo do uso de bloqueio antimicrobiano e bloqueio com heparina em pacientes com CVC em uso de NPT, HDL e em pacientes oncológicos, identificou a redução de incidência nos índices acerca da resistência bacteriana não fora investigada nesta pesquisa, contudo a literatura destaca a alta resistência bacteriana sendo um dos agravantes e problemáticas encontradas para o tratamento das infecções (Melo et al, 2023;Lima et al, 2023;Fidelis;Leme, 2022).…”

Section: Resultsunclassified

Análise de casos de infecção primária de corrente sanguínea laboratorial em um hospital universitário

Costa,

De Moura,

Ribeiro

et al. 2023

CLCS

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Analisar os casos de infecção primária de corrente sanguínea laboratorial notificados em um hospital universitário no interior do Pernambuco durante os anos de 2019 a 2022. Estudo quantitativo, descritivo, observacional e transversal, a partir de dados secundários de fichas de investigação da comissão de controle de infecção hospitalar. Foi realizada análise estatística descritiva simples, cálculo de densidade de incidência e avaliação da tendência da densidade de incidência através do programa estatístico joinpoint versão 4.5.0.1. Dos 24 casos identificados, a maioria era do sexo masculino, 79%, idade média de 58,3 anos, média de tempo para desenvolvimento da infecção em 15,7 dias e o desfecho óbito em 58,3% da amostra. Houve tendência de aumento da densidade de incidência no período. O perfil dos casos, a incidência de óbitos e o aumento na taxa de densidade de incidência indicam necessidade de aperfeiçoamento nas ações de prevenção e vigilância das infecções.

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Section: Resultsunclassified

Análise de casos de infecção primária de corrente sanguínea laboratorial em um hospital universitário

Costa,

De Moura,

Ribeiro

et al. 2023

CLCS

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“…Several studies have shown the prevalence of CLABSI caused by Gram-negative organisms, with coagulase-negative Staphylococcus being the main germ ( 19 - 20 ) . These findings corroborate our study, as bacteria from the coagulase-negative Staphylococcus group predominated in the blood cultures (41.4%), and infections may be associated with catheter handling or site colonization during insertion.…”

Section: Discussionmentioning

confidence: 99%

“…Diversos estudios han demostrado la prevalencia de infección de la circulación sanguínea relacionada con catéter venoso central causada por organismos Gram negativos, siendo el Staphylococcus coagulasa negativo el principal germen ( 19 - 20 ) . Estos hallazgos corroboran nuestro estudio, ya que en los hemocultivos predominaron bacterias del grupo de los Staphylococcus coagulasa negativo (41,4%), y las infecciones pueden estar asociadas con la manipulación del catéter o la colonización del sitio durante la inserción.…”

Section: Discussionunclassified

Central line-associated bloodstream infections in patients with COVID-19

Acosta,

Ceratti,

Santos

et al. 2024

Rev. Latino-Am. Enfermagem

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Objective: to investigate the association between central line-associated bloodstream infections and clinical and care variables of intensive care unit patients with COVID-19 hospitalized at a reference public health institution. Method: a case-control study. Results: the study sample consisted of 70 patients diagnosed with central line-associated bloodstream infections (case group) and 70 non-infected patients (control group). Most patients were male, with mean age of 57.93±13.93 years old and provided with a double lumen catheter. Median time of central line-associated bloodstream infections onset was 11 (8-18) days. Longer time on mechanical ventilation ( P =0.014; OR: 1.79; 95% CI: 0.91-3.51) and prone position ( P =0.017; OR: 2.41; 95% CI: 1.22-4.81) were associated with central line-associated bloodstream infections onset. Conclusion: longer time on invasive mechanical ventilation and prone position contributed to central line-associated bloodstream infections onset in COVID-19 patients.

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“…The hospital environment has high rates of antimicrobial resistance due to the large handling of hospital antimicrobials in these places, causing a global health problem with estimates of thousands of deaths in the next years (Wu et al, 2021;Melo et al, 2021). In 2017, S. pneumoniae joined the list of 12 priority pathogenic bacteria that was released by the World Health Organization due to of the increase in the rate of infections and resistance to antimicrobials (WHO, 2017).…”

Section: Discussionmentioning

confidence: 99%

Colonization by Streptococcus pneumoniae among children in Porto Velho, Rondônia, Western Brazilian Amazon

et al. 2022

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Streptococcus pneumoniae is one of the primary pathogens that are associated with acute respiratory infections (ARI) that cause high rates of morbidity and mortality among children under five years of age in developed and developing countries. This study aimed to determine the prevalence of nasopharyngeal colonization, the antimicrobial resistance profile, and the capacity for biofilm formation by S. pneumoniae isolated from children aged 0-6 years with ARI throughout the Porto Velho-RO. A total of 660 swabs were collected from children with ARI. Molecular and biochemical tests were performed to characterize the isolates. The disk-difusion method and the E-test were used for antimicrobial sensitivity testing (TSA). Biofilm formation capacity was assessed using microtiter plate assays, and serotype detection was acheived using polymerase chain reaction (PCR) analyses. The colonization rate for S. pneumoniae was 8.9% (59/660) and exhibited a high prevalence in children under 23 months of age 64.4% (38/59). The observed serotypes were 9V and 19F with frequencies of 1.7% (1/59) and 13.6% (8/59), respectively. The antimicrobial susceptibility test revealed 100% (59/59) sensitivity to vancomycin. In contrast, trimethoprim and oxacillin exhibited high resistance rates of 76.3% (45/59) and 52.5% (31/59), respectively. Of the biofilm-forming isolates, 54.8% (23/42) possessed resistance to some antimicrobials. In this study, S. pneumoniae showed high rates of antimicrobial resistance and the ability to form biofilms, as these are factors that favor bacterial persistence and can cause serious damage to the host.

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Microbiological characteristics of bloodstream infections in a reference hospital in northeastern Brazil

Cited by 4 publications

References 13 publications

Análise de casos de infecção primária de corrente sanguínea laboratorial em um hospital universitário

Análise de casos de infecção primária de corrente sanguínea laboratorial em um hospital universitário

Central line-associated bloodstream infections in patients with COVID-19

Colonization by Streptococcus pneumoniae among children in Porto Velho, Rondônia, Western Brazilian Amazon

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