The cortical regions and white matter tracts underlying auditory comprehension in patients with primary brain tumor

Zhang, Jie; Yao, Ye; Wu, Jinsong; Rolls, Edmund T.; Sun, Ce‐chen; Bu, Linghao; Lu, Junfeng; Lin, Ching-Po; Feng, Jian‐feng; Mao, Ying; Zhou, Lei

doi:10.1002/hbm.26161

Cited by 3 publications

(1 citation statement)

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“…ABC is the Chinese standardized adaptation of the Western Aphasia Battery (WAB), 13 ABC has been widely used in previous studies of Chinese native speakers and recommended by Chinese linguistic experts. 14-19 ABC speech fluency was assessed with two tasks, the ‘conversational interview’ task and the ‘description’ task ( Supplementary Fig. 1 ).…”

Section: Methodsmentioning

confidence: 99%

A speech fluency brain network derived from gliomas

Sun,

Zhang,

et al. 2024

Brain Communications

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The brain network of speech fluency has not yet been investigated via a study with a large and homogenous sample. This study analysed multimodal imaging data from 115 patients with low-grade glioma to explore the brain network of speech fluency. We applied voxel-based lesion-symptom mapping to identify domain-specific regions and white matter pathways associated with speech fluency. Direct cortical stimulation validated the domain-specific regions intra-operatively. We then performed connectivity-behaviour analysis with the aim of identifying connections that significantly correlated with speech fluency. Voxel-based lesion-symptom mapping analysis showed that damage to domain-specific regions (the middle frontal gyrus, the precentral gyrus, the orbital part of inferior frontal gyrus, and the insula) and white matter pathways (corticospinal fasciculus, internal capsule, arcuate fasciculus, uncinate fasciculus, frontal aslant tract) are associated with reduced speech fluency. Furthermore, we identified connections emanating from these domain-specific regions that exhibited significant correlations with speech fluency. These findings illuminate the interaction between domain-specific regions and seventeen domain-general regions—encompassing the superior frontal gyrus, middle frontal gyrus, inferior frontal gyrus, and rolandic operculum, superior temporal gyrus, temporal pole, inferior temporal pole, middle cingulate gyrus, supramarginal gyrus, fusiform gyrus, inferior parietal lobe, as well as subcortical structures such as thalamus—implicating their collective role in supporting fluent speech. Our detailed mapping of the speech fluency network offers a strategic foundation for clinicians to safeguard language function during the surgical intervention for brain tumors.

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Section: Methodsmentioning

confidence: 99%

A speech fluency brain network derived from gliomas

Sun,

Zhang,

et al. 2024

Brain Communications

Self Cite

View full text Add to dashboard Cite

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The cortical regions and white matter tracts underlying auditory comprehension in patients with primary brain tumor

Zhang

Yao

et al. 2022

Human Brain Mapping

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The comprehension of spoken language is one of the most essential language functions in humans. However, the neurological underpinnings of auditory comprehension remain under debate. Here we used multi‐modal neuroimaging analyses on a group of patients with low‐grade gliomas to localize cortical regions and white matter tracts responsible for auditory language comprehension. Region‐of‐interests and voxel‐level whole‐brain analyses showed that cortical areas in the posterior temporal lobe are crucial for language comprehension. The fiber integrity assessed with diffusion tensor imaging of the arcuate fasciculus and the inferior longitudinal fasciculus was strongly correlated with both auditory comprehension and the grey matter volume of the inferior temporal and middle temporal gyri. Together, our findings provide direct evidence for an integrated network of auditory comprehension whereby the superior temporal gyrus and sulcus, the posterior parts of the middle and inferior temporal gyri serve as auditory comprehension cortex, and the arcuate fasciculus and the inferior longitudinal fasciculus subserve as crucial structural connectivity. These findings provide critical evidence on the neural underpinnings of language comprehension.

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