The Correlations Between Epidemiological and Clinical Characteristics, laboratory tests and CT Scan reports in the diagnosis of cases 2019 novel coronavirus pneumonia. A Diagnostic Accuracy Study

Abstract

Background: The role of laboratory parameters and the relationship of them with radiology reports, CT scan and clinical outcomes in screening of COVID-19 patients not been definitely established, but this disease presented a major challenge in the field of clinical tests, radiology reports, clinical outcomes that help to monitoring and treatment COVID-19 disease. Methods: This study was performed on 340 suspected COVID-19 patients, who presented to Chamran Hospital, Shiraz University of Medical Sciences Shiraz, Iran from 20 February to 31 August, 2020. Information each patient’s will be completed using a data collection forms based on records. The evaluation of lungs involvement in CT scan and their relationship with laboratory indicator including biochemical and hematological factors, is the best scale for the severity and prognosis of Covid 19 patients. Results and Conclusion: The findings of this study indicated ALT, AST, CRP, NEU, LDH, and Urea have very good accuracy in predicting cases with positive RT-PCR for COVID-19, respectively. In this study we shown the correlation of clinical and laboratory findings with CT-based quantitative score of pulmonary involvement in COVID-19 pneumonia and attempted that our findings could be usable to development future clinical research associated with COVID-19 infection and show the relationship of reports CT scan and clinical outcomes in the diagnosis and severity of patients with COVID-19.

Covid-19 Hastalığında Laboratuvar Parametrelerinin Tanısal Değerinin ROC Eğrisi ile İncelenmesi

“…When considered on the basis of SARS disease, the relevant laboratory data; CRP, lymphopenia, LDH and creatine kinase levels were increased (18). In another similar study; in cases with positive RT-PCR for Covid-19, ALT, AST, CRP, NEU, LDH and Urea were determined respectively; it has been shown to be quite reliable in testing the disease (19).…”

An overview on nanoparticle-based strategies to fight viral infections with a focus on COVID-19

“…SARS-CoV-2 S protein bind to the Angiotensin-converting enzyme 2 (ACE2) host cell [ 31 ]. As soon as prosperous entrance, the genomic RNA (sgRNA) SARS-CoV-2 acts as a transcript and lets the cap-affiliate translation of ORF1a generating polyprotein pp1a [ 32 ]. Then, the structural proteins are incorporated into membranes of the endoplasmic reticulum and transported to the endoplasmic reticulum–Golgi intermediate compartment (ERGIC).…”