An overview on nanoparticle-based strategies to fight viral infections with a focus on COVID-19

Yasamineh, Saman; Kalajahi, Hesam Ghafouri; Yasamineh, Pooneh; Yazdani, Yalda; Gholizadeh, Omid; Tabatabaie, Raheleh; Afkhami, Hamed; Davodabadi, Fatemeh; farkhad, Alireza Khanalipour; Pahlevan, Daryoush; Firouzi-Amandi, Akram; Nejati-Koshki, Kazem; Dadashpour, Mehdi

doi:10.1186/s12951-022-01625-0

Cited by 39 publications

(14 citation statements)

References 182 publications

(195 reference statements)

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“…People with MS treated with DMT usually have a higher risk of infection, with rituximab having the most significant severe infection incidence [84]. However, COVID-19 infection severity was not associated with the presence of DMT, which was related to a lower risk of hospitalization in univariate analysis [85,86].…”

Section: Sars-cov-2 Role In Msmentioning

confidence: 99%

Comprehensive Investigations Relationship Between Viral Infections and Multiple Sclerosis Pathogenesis

et al. 2022

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Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system (CNS). Compared to other types of self-limiting myelin disorders, MS compartmentalizes and maintains chronic inflammation in the CNS. Even though the exact cause of MS is unclear, it is assumed that genetic and environmental factors play an important role in susceptibility to this disease. The progression of MS is triggered by certain environmental factors, such as viral infections. The most important viruses that affect MS are Epstein-Barr virus (EBV), human herpes virus 6 (HHV-6), human endogenous retrovirus (HERV), cytomegalovirus (CMV), and varicella zoster virus (VZV). These viruses all have latent stages that allow them to escape immune detection and reactivate after exposure to various stimuli. Furthermore, their tropism for CNS and immune system cells explains their possible deleterious function in neuroinflammation. In this study, the effect of viral infections on MS disease focuses on the details of viruses that can change the risk of the disease. Paying attention to the most recent articles on the role of SARS-CoV-2 in MS disease, laboratory indicators show the interaction of the immune system with the virus. Also, strategies to prevent viruses that play a role in triggering MS are discussed, such as EBV, which is one of the most important.

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Section: Sars-cov-2 Role In Msmentioning

confidence: 99%

Comprehensive Investigations Relationship Between Viral Infections and Multiple Sclerosis Pathogenesis

et al. 2022

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“…For COVID-19 prevention, several vaccines have been developed, including the mRNA base vaccine (Pfizer-BioNTech and Moderna) and the inactivated vaccine (Sinopharm), as well as a number of pharmacological strategies, primarily based on the repurposing of drugs such as dexamethasone, Favipiravir, and Remdesivir [ 141 ]. In addition, SARS-CoV-2 infection is treated with antibiotics, oxygen therapy, cell therapy, antibody therapy, and convalescent plasma approach, which is an immunotherapy strategy using viral-specific antibodies [ 1 , 142 ]. Based on reports of the World Health Organization (WHO) on November.…”

Section: Therapeutic Procedures Of the Sars-cov-2 Infectionmentioning

confidence: 99%

“…The two primary types of human CoVs are alpha and beta-CoVs. The coronavirus disease 2019 (COVID-19) pandemic is caused by the SARS-CoV-2 (severe acute respiratory syndrome coronavirus), which belongs to the beta-CoV family [ 1 ]. About 636 million people have been infected with this SARS-CoV-2, and about 6.5 million patients have died due to COVID-19 by November 2022 [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic and diagnostic applications of nanoparticles in the management of COVID-19: a comprehensive overview

Gholizadeh

Yasamineh

Amini

et al. 2022

Virol J

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In December 2019, Coronavirus Disease 2019 (COVID-19) was reported in Wuhan, China. Comprehensive strategies for quick identification, prevention, control, and remedy of COVID-19 have been implemented until today. Advances in various nanoparticle-based technologies, including organic and inorganic nanoparticles, have created new perspectives in this field. These materials were extensively used to control COVID-19 because of their specific attribution to preparing antiviral face masks, various safety sensors, etc. In this review, the most current nanoparticle-based technologies, applications, and achievements against the coronavirus were summarized and highlighted. This paper also offers nanoparticle preventive, diagnostic, and treatment options to combat this pandemic. Graphical Abstract

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“…For instance, Raghuwanshi et al (2012) developed plasmid DNAloaded chitosan nanoparticles and used them as a vaccine for different variants of SARS. Literature reviews have already shown the immense potential of nanotechnology in coping with pandemics like COVID-19 (Yasamineh et al, 2022). Detailed studies are available that report the potential of nanotechnology against SARS-CoV-2 (Sahu et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Application of nanomaterials against SARS-CoV-2: An emphasis on their usefulness against emerging variants of concern

Iqbal

Khan

Ali

et al. 2022

Front. Nanotechnol.

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Researchers are now looking to nanomaterials to fight serious infectious diseases that cause outbreaks and even pandemics. SARS-CoV-2 brought chaos to almost every walk of life in the past 2 years and has challenged every available treatment method. Although vaccines were developed in no time against it, the most pressing issue was the emergence of variants of concern arising because of the rapidly evolving viral strains. The higher pathogenicity and, in turn, the higher mortality rate of infections caused by these variants renders the existing vaccines less effective and the effort to produce further vaccines a costly endeavor. While several techniques, such as immunotherapy and repurposed pharmaceutical research, are being studied to minimize viral infection, the fundamentals of nanotechnology must also be considered to enhance the anti-SARS-CoV-2 efforts. For instance, silver nanoparticles (AgNPs) have been applied against SARS-CoV-2 effectively. Similarly, nanomaterials have been tested in masks, gloves, and disinfectants to aid in controlling SARS-CoV-2. Nanotechnology has also contributed to diagnoses such as rapid and accurate detection and treatment such as the delivery of mRNA vaccines and other antiviral agents into the body. The development of polymeric nanoparticles has been dubbed a strategy of choice over traditional drugs because of their tunable release kinetics, specificity, and multimodal drug composition. Our article explores the potential of nanomaterials in managing the variants of concern. This will be achieved by highlighting the inherent ability of nanomaterials to act against the virus on fronts such as inhibition of SARS-CoV-2 entry, inhibition of RNA replication in SARS-CoV-2, and finally, inhibition of their release. In this review, a detailed discussion on the potential of nanomaterials in these areas will be tallied with their potential against the current and emerging future variants of concern.

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An overview on nanoparticle-based strategies to fight viral infections with a focus on COVID-19

Cited by 39 publications

References 182 publications

Comprehensive Investigations Relationship Between Viral Infections and Multiple Sclerosis Pathogenesis

Comprehensive Investigations Relationship Between Viral Infections and Multiple Sclerosis Pathogenesis

Therapeutic and diagnostic applications of nanoparticles in the management of COVID-19: a comprehensive overview

Application of nanomaterials against SARS-CoV-2: An emphasis on their usefulness against emerging variants of concern

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