The Correlation of the Bga Blood Group with the HL-A7
Leucocyte Group: Demonstration of Antigenic Sites
on Red Cells and Leucocytes

Morton, J.A.; Pickels, M.M.; Sutton, L.

doi:10.1159/000465864

Cited by 26 publications

(36 citation statements)

References 9 publications

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“…However, Morton, Pickles, and Sutton (1969), using an AutoAnalyzer technique, showed a correlation between anti-Bga and HL-A 7 but the present series did not contain enough examples of anti-Bga to investigate this particular relationship. In this paper they suggested that manual methods are considerably less sensitive than those using the AutoAnalyzer and this may explain, at 4 least partially, our apparent failure to find the correlation indicated above.…”

Section: Discussioncontrasting

confidence: 53%

Association of white cell and red cell antibodies in human sera

Ross¹,

James²

1973

J Clin Pathol

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SYNOPSIS Five hundred and eighteen human sera containing known red cell antibodies were tested for lymphocytotoxic antibodies and 81 sera were found to contain them. Thirty-nine antibodies were fully characterized. The frequencies of anti-I, K, Vw, and Wra were significantly greater in those of the 518 sera which also contained white cell antibodies.Four hundred and ninety-four of the 518 sera containing red cell antibodies contained anti-Rh (Boyum, 1968), the concentration being adjusted to 1 x 106 cells/ml.

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Section: Discussioncontrasting

confidence: 53%

Association of white cell and red cell antibodies in human sera

Ross¹,

James²

1973

J Clin Pathol

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“…Recently Morton et al [22] described the correlation between the Bga red cell antigen and the HL-A7 antigen: in the serum from 8 pregnant women, antibodies were found which reacted by an AA technique alone. A good concordance between the reaction of red cells and lymphocytes, the latter tested by lymphocytotoxicity, was found in Bg(a-|-) and Bg(a-) individuals.…”

Section: Discussionmentioning

confidence: 99%

Automated Red Cell Antibody Analysis. A Parallel Study

Perrault¹,

Högman²

1971

Vox Sanguinis

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The AutoAnalyzer method of red blood cell antibody detection can be adapted to identify the serological specificity of these same antibodies. In the present study, 1,152 AA-positive sera obtained during AA screening were investigated. In 217 (19%) of these sera blood group antibodies were identified by manual techniques. Since the AA techniques are generally more sensitive than manual methods an attempt was made to identify antibodies by the AA methods in 823 sera which were negative manually. The low-ionic strength-Polybrene (LISP) method was found to be suitable for antibody identification because of its sensitivity in the detection of most red cell antibodies and the small technical deviations of OD from the base-line. The bromeline-methyl cellulose (BMC) technique is less sensitive and often more difficult to interpret in antibody identification. In some cases, however, this method was the only one that gave positive reactions. In 214 instances antibodies were identified by the AA techniques, about half of which were anti-D’s, the others being RBC antibodies of more or less rare varieties. The relative frequency of these rare antibodies was higher in the group of manual-negative sera, 47 versus 21%, normally found. Positive identification but no clear-cut blood type antibody was found in 155 cases (19%). Indications were obtained that some of the reactions were due to HL-A antibodies. Antibodies to HL-A7 and HL-A5 were found to react with red cells. In addition the AA techniques seemed to be more sensitive to detect RBC autoantibodies than standard manual methods. However, the usefulness of the AA techniques for routine antibody identification is diminished by the relative slowness of the machine.

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“…Both specific and nonspecific reactions to other HLA antisera may also occur. Five patients were followed in detail and the reason for the increase in antigen strength was investigated without a conclusive result.The red cell antigens Bga, Bgb and Bgc are related to the HLA antigens B7, B17 and A28 [19,20]. The considerable varia tion in strength of reaction is one of the salient features of the Bg system, donors showing the strongest reactions can be de tected by manual methods either in saline or by the antiglobulin reaction [3,6,7,17] whereas other donors only react when the AutoAnalyzer is used [25], We have found that the relative antigen strength of our laboratory staff has remained unaltered over a period of many years.…”

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confidence: 99%

Increase in Strength of Red Cell Bg^a Antigen Following Infectious Mononucleosis

Morton¹,

Pickels²,

Darley³

1977

Vox Sanguinis

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Following an attack of infectious mononucleosis, the red cells of HLA B7 patients may show a greatly increased reactivity with anti-Bg^a antibodies. This occurs from about the 3rd week of the disease, the reactivity then slowly decreasing over a period of months or years. Both specific and nonspecific reactions to other HLA antisera may also occur. Five patients were followed in detail and the reason for the increase in antigen strength was investigated without a conclusive result.

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The Correlation of the Bga Blood Group with the HL-A7 Leucocyte Group: Demonstration of Antigenic Sites on Red Cells and Leucocytes

Cited by 26 publications

References 9 publications

Association of white cell and red cell antibodies in human sera

Association of white cell and red cell antibodies in human sera

Automated Red Cell Antibody Analysis. A Parallel Study

Increase in Strength of Red Cell Bg^a Antigen Following Infectious Mononucleosis

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