The Correlation of Serum Growth Differentiation Factor-15 Level in Patients with Obstructive Sleep Apnea

Sarı, Kamran; Ede, Hüseyin; Gencer, Zeliha Kapusuz; Özkırış, Mahmut; Göçmen, Ayşe Yeşim; İntepe, Yavuz Selim

doi:10.1155/2015/807683

Cited by 8 publications

(7 citation statements)

References 34 publications

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“…In our results, interestingly, it was revealed that there is no significant relationship between OSAS severities and GDF-15. However, studies on GDF-15 have found it associated with many chronic diseases (8)(9)(10)(11)(12)(13)(14). Studies have more clearly demonstrated the relationship between cardiac pathologies and GDF-15 (5,12).…”

Section: Discussionmentioning

confidence: 99%

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The relationship between disease severity and GDF-15 in individuals diagnosed with obstructive sleep apnea syndrome

BODUROGLU¹,

Zorlu²,

Ilanbey³

et al. 2022

JECM

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Obstructive sleep apnea syndrome (OSAS) is characterized with interruption of sleep with apnea attacks and is associated with various diseases such as metabolic syndrome. GDF-15 (Growth differentiation factor 15) is a cytokine belonging to the transforming growth factor – β superfamily and it has been found to be associated with chronic heart failure, acute pulmonary embolism, and acute attacks of chronic obstructive pulmonary disease (COPD). It was aimed to evaluate the relationship between disease severity and mean GDF-15 in patients diagnosed with OSAS. Our study was carried out with 75 patients with OSAS. GDF-15 levels were checked by in the morning fasting blood test. Among the 75 patients, 27 constituted the mild, 22 constituted the moderate and 26 constituted the severe OSAS groups. The mean ages of the patients were not significantly different between groups (53.17±10, 54.61±10.2 and 53.5±11.6 respectively; p>0,05). GDF-15 levels were not significantly different between groups separately (p>0.05). There was only a weak positive relationship between GDF-15 and NREM and REM (p<0.05). In our study, it was revealed that there was no significant relationship between the OSAS severity groups and GDF-15. Our determination of a positive relationship with NREM and REM may have been related to reduction of minute ventilation experienced in OSAS-diagnosed patients, tachycardic fluctuations, their more severe nature and increased right ventricular pressure. Consequently, our current knowledge indicates that GDF-15 is not much guiding in the prediction and monitoring of OSAS severity.

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Section: Discussionmentioning

confidence: 99%

“…A study where OSAS patients were compared to a control group did not find a GDF-related difference. However, in the study, the OSAS group was assessed without separation into sub-groups based on severity (mild-moderate-severe) (10).…”

Section: Introductionmentioning

confidence: 99%

The relationship between disease severity and GDF-15 in individuals diagnosed with obstructive sleep apnea syndrome

BODUROGLU¹,

Zorlu²,

Ilanbey³

et al. 2022

JECM

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“…Отмечена отрицательная корреляция уровня GDF-15 с ФВ ЛЖ (R=-0,29; p=0,04). Созвучные результаты демонстрируют и другие исследователи, описывая в ряде клинических работ связь уровня GDF-15 с факторами риска ФП (ожирение, СД, возраст, атеросклероз, АГ, ХСН, ренальная дисфункция, степень фиброза ЛП) [18][19][20][21][22][23][24]. В данном Для изучения признаков, способных влиять на клиническое течение ФП в виде ее рецидивирования, были проведены однофакторный и многофакторный регрессионные анализы Кокса.…”

Section: результаты и обсуждениеunclassified

“…Существуют исследования, демонстрирующие ассоциацию уровня GDF-15 с площадью фиброза левого предсердия, индексом объема левого предсердия, уровнем N-концевого фрагмента мозгового натрийуретического пептида при ФП [19,20]. Данные о содержании GDF-15 в крови пациентов с СОАС скудны: в доступной научной литературе приведено лишь исследование Kamran S. и соавт., где не было обнаружено статистически значимых различий по уровню GDF-15 у пациентов с наличием СОАС и у пациентов без данного синдрома [21]. В связи с вышеизложенным определенный интерес представляет вопрос о том, сопровождается ли сочетание ФП и СОАС изменениями содержания GDF-15, а также эффективен ли GDF-15 как прогностический биомаркер рецидива ФП в данной субпопуляции пациентов.…”

Section: Introductionunclassified

Growth Differentiation Factor-15 as a Biomarker of Atrial Fibrillation Recurrence after Electrical Cardioversion in Patients with Persistent Atrial Fibrillation and Obstructive Sleep Apnea

Балабанович¹,

Шишко²,

Шулика³

2022

Рецепт

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С целью оценки диагностического потенциала фактора дифференцировки роста-15 (GDF-15) как прогностического биомаркера рецидива фибрилляции предсердий (ФП) после электрической кардиоверсии обследовано 46 пациентов в возрасте 57,2±6,4 года, страдающих персистирующей формой ФП: 35 (76,1%) мужчин и 11 (23,9%) женщин. С учетом наличия синдрома обструктивного апноэ во сне (СОАС) были сформированы 2 клинические группы: группа F -11 (23,91%) пациентов без СОАС; группа FA -35 (76,09%) пациентов с СОАС. Исходно у всех пациентов определяли уровень GDF-15 в сыворотке крови методом иммуноферментного анализа. Всем обследуемым была выполнена плановая эффективная электрическая кардиоверсия. Период наблюдения составил 12 (11-13) месяцев, по истечении которого оценивалась конечная точка в виде наличия рецидива ФП. За период наблюдения у 29 (63,04%) пациентов выборки развился рецидив ФП, 17 (36,96%) пациентам сохранить синусовый ритм удалось. При наличии СОАС у пациентов с ФП уровень GDF-15 выше, чем у пациентов без данного синдрома (1014,27 (885,0; 1302,0) пг/мл и 661,07 (625,71; 835,02) пг/мл соответственно; р=0,001), и изменения содержания биомаркера ассоциированы со сроком наступления рецидива (R=-0,71; p<0,0001), с индексом апноэ/гипопноэ (R=0,47; p=0,001), с индексом массы тела (R=0,45; p=0,002), с фракцией выброса левого желудочка (R=-0,29; p=0,04). По результатам многофакторного регрессионного анализа Кокса установлено, что независимыми предикторами рецидива ФП являются уровень GDF-15 (ОШ 1,004; 95% ДИ 1,002-1,006; p<0,0001) и размер левого предсердия (ОШ 1,108 (95% ДИ 1,007-1,218; р=0,03). Методом ROC-анализа было определено пороговое значение уровня GDF-15 более 967,78 пг/мл (р<0,001), позволяющее с чувствительностью 75,9% и специфичностью 88,2% предсказать развитие рецидива ФП в течение года после электрической кардиоверсии у пациентов с ФП в сочетании с СОАС.

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“…Interestingly, overexpressed GDF15 is able to extend animal lifespan [ 14 ]. Only one study investigated GDF15 in relation to sleep disorders, and reported no correlation between GDF15 serum levels and Obstructive Sleep Apnea Syndrome (OSAS) [ 15 ]. HN is a mitochondrial DNA-encoded peptide endowed with cytoprotective and anti-apoptotic effects [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Both objective and paradoxical insomnia elicit a stress response involving mitokine production

Martucci

Conte

Ostan

et al. 2020

Aging

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Chronic insomnia is the most common sleep disorder in the elderly population. From 9 to 50% of patients suffer of paradoxical insomnia, with the same symptoms and ailments, though characterized by normal sleep patterns. We have investigated the level of parameters related to stress in a group of post-menopausal female patients (age range 55-70 years) suffering by either objective or paradoxical insomnia, in particular we have measured 24-hours urinary cortisol, allostatic load index, Perceived Stress Scale (PSS) score, and, for the first time, mitokines (mitochondrial stress response molecules) such as FGF21, GDF15 and Humanin (HN). Results show that the two groups are different as far as sleep efficiency score, as expected, but not for stress parameters, that in some cases resulted within the normality range, although quite close to the top threshold (such as cortisol) or much higher with respect to normality ranges (such as PSS). Therefore, the consequences of paradoxical insomnia on the expression of these parameters are the same as objective insomnia. As far as the level of mitokines, we showed that FGF21 and HN in particular resulted altered (decreased and increased, respectively) with respect to control population, however with no difference between the two groups of patients.

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The Correlation of Serum Growth Differentiation Factor-15 Level in Patients with Obstructive Sleep Apnea

Cited by 8 publications

References 34 publications

The relationship between disease severity and GDF-15 in individuals diagnosed with obstructive sleep apnea syndrome

The relationship between disease severity and GDF-15 in individuals diagnosed with obstructive sleep apnea syndrome

Growth Differentiation Factor-15 as a Biomarker of Atrial Fibrillation Recurrence after Electrical Cardioversion in Patients with Persistent Atrial Fibrillation and Obstructive Sleep Apnea

Both objective and paradoxical insomnia elicit a stress response involving mitokine production

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