The correlation between nonylphenol concentration in brain regions and resulting behavioral impairments

Kazemi, Sohrab; Khalili-Fomeshi, Mohsen; Akbari, Atefeh; Kani, Seydeh Narges Mousavi; Ahmadian, Seyed Raheleh; Ghasemi-Kasman, Maryam

doi:10.1016/j.brainresbull.2018.03.003

Cited by 38 publications

(15 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous investigations have evidenced that perinatal exposure to POPs can lead to learning and memory damage in rats [39]. NP as a potent POP has been demonstrated to be potentially neurotoxic which, leads to spatial memory and cognitive impairment in animal models [34]. In this study, we used NP to induce learning and memory impairment as an animal model.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Thymoquinone Improved Nonylphenol-Induced Memory Deficit and Neurotoxicity Trough its Antioxidant and Neuroprotective Effects

Lotfi¹,

Kazemi²,

Ebrahimpour³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Nonylphenol (NP) as a well-known endocrine-disrupter chemical (EDCs), has several harmful effects on the CNS such as neuroendocrine disruption, cognitive impairment, and neurotoxicity. Thymoquinone (TQ) is a main bioactive compound in the black seeds of nigella sativa (NS) possesses antioxidant, anti-inflammatory, and neuroprotective properties. This study was designed to assess the neuroprotective effect of TQ against NP-induced memory deficit and neurotoxicity in rats. To induce memory impairment, NP (25mg/kg) was used as gavage in male Wistar rats for 21 days. TQ i.p. injection at doses 2.5, 5, and 10mg/kg was done in NP-treated animals at the same time. Morris Water Maze (MWM) test was performed to assess spatial memory. The rats` hippocampus tissues were isolated for histopathological testes. Biochemical, molecular and cellular tests were done for proving more details. The results showed TQ at dose 5 mg/kg significantly improved NP-induced memory impairment. Histological data proved that TQ decreased the number of necrotic cells in the hippocampus which was increased in NP-treated animals. Biochemical analysis showed that the levels of glutathione (GSH) and total antioxidant capacity (TAC) were significantly increased in TQ treated groups compared to the NP group. The molecular analysis has shown that NP increased GFAP and decreased α-Syn expression level and TQ treatment did the reverse. In vitro study in astrocytes isolated from mice brain proved that TQ significantly increased cell viability in cytotoxicity induced by NP. This study strongly indicates that TQ has therapeutic and neuroprotective effects on NP-induced neurotoxicity through reduction of oxidative damages and neuroinflammation.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported that exposure to NP can lead to hippocampus injuries, including learning and memory impairment [34]. MWM task was performed to assess spatial learning and memory in different experimental groups.…”

Section: Tq Attenuated Learning and Memory Impairment In Np Treated Animalsmentioning

confidence: 99%

Thymoquinone Improved Nonylphenol-Induced Memory Deficit and Neurotoxicity Trough its Antioxidant and Neuroprotective Effects

Lotfi¹,

Kazemi²,

Ebrahimpour³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Hayley and Kuhlmann et al found that the level of BDNF may be related to the severity of depression, i.e., the more severe the depressive symptoms, the lower the level of BDNF in the brain ( Sohrab et al, 2018 ). Our study found that the depression score was negatively correlated with BDNF.…”

Section: Discussionmentioning

confidence: 99%

Hospital-based case control study and animal study on the relationship between nonylphenol exposure and depression

Luo

et al. 2021

PeerJ

View full text Add to dashboard Cite

Objectives The aim of this work is to explore the association between chronic exposure to nonylphenol (NP), a representative environmental endocrine disruptor (EED), and the risk of depression and its potential mechanism. Methods A hospital-based case control study was conducted from August to December 2018. Forty-one patients with confirmed depression and 47 healthy volunteers were recruited. In vitro, 20 rats were randomly divided into the control group (corn oil) and NP exposure group (n = 10 per group), which were gavaged at a dose of 4 mg/kg w/day for 180 days. Results The depressed patient group had higher Zung Self-Rating Depression Scale (SDS) (P < 0.001) and Self-Rating Anxiety Scale (SAS) (P < 0.001) scores than the healthy group. The serum NP level (P = 0.009) in the depressed group was higher than that in the healthy group, and the BDNF level (P = 0.001) was lower. The serum levels of monoamine neurotransmitters dopamine (DA) (P = 0.070), epinephrine (E) (P = 0.001), and noradrenaline (NE) (P = 0.000) were lower than those in the healthy group. In the sucrose preference test, the sucrose preference time for the exposure group of rats was lower than that of the control group (P < 0.001). In the forced swim test, a longer resting time was measured for the exposure group of rats as compared to the control group (P < 0.05). The level of NP (P < 0.001) in the brain tissue of the NP exposure group was higher than that in the control group, and the serum level of brain-derived neurotrophic factor (BDNF) (P = 0.004) was lower. Histopathological examination of the brain biopsies illustrated that the neuronal cells and nuclei in the hippocampus of the exposed group exhibited slight shrinkage. Conclusion Chronic exposure to NP at environmental doses will result in the accumulation of NP in the brain and blood, and induction of depression, which might be associated with the alterations in the expression levels of BDNF and monoamine neurotransmitters.

show abstract

“…Nonylphenol has a weak oestrogenic activity and can inhibit the interaction between oestrogen and its receptor (Choi et al., 2014). Several studies have demonstrated that NP causes reproductive dysfunction and enhances the production of reactive oxygen species (ROS) in the testis, liver and brain of animals (Kazemi et al, 2018; Kazemi, Feizi, et al, 2016; Kazemi, Mousavi Kani, et al, 2016). It has been evident that NP could reduce testis size, decrease circulating testosterone, disturb the testicular structure and suppress spermatogenesis (Tabassum et al., 2017; Ying et al., 2012).…”

Section: Introductionmentioning

confidence: 99%

Ameliorative effect of Alpinia officinarum Hance extract on nonylphenol‐induced reproductive toxicity in male rats

et al. 2021

Self Cite

View full text Add to dashboard Cite

Nonylphenol (NP), an endocrine‐disrupting chemical, interferes with reproductive function and induces oxidative stress in different organs, including the testis and prostate. Alpinia officinarum Hance (ALP), a plant species of the Zingiberaceae family, has proven antioxidant properties. This study aimed to evaluate the effect of the alcoholic extract of ALP treatment on NP‐induced reproductive toxicity and oxidative stress in male rats using biochemical and histopathological biomarkers. Our experimental groups were defined as follows: oil treatment (control), NP 10 mg/kg, ALP 10 mg/kg (ALP HD), NP + ALP 5 mg/kg (NP + ALP LD) and NP + ALP 10 mg/kg (NP + ALP HD). NP administration caused significant cytotoxicity and a significant increase in oxidative stress prostate‐specific antigen (PSA) levels accompanied by a significant reduction in testosterone levels. The relative weight of the testis of both NP + ALP LD and NP + ALP HD groups was significantly decreased compared to the control group. Histopathological evaluations revealed destructive effects in testis and prostate tissue samples. In conclusion, ALP administration improved cytotoxicity, oxidative stress, testosterone and PSA levels, and testis and prostate tissue destructive effects induced by the NP in male rats.

show abstract

The correlation between nonylphenol concentration in brain regions and resulting behavioral impairments

Cited by 38 publications

References 32 publications

Thymoquinone Improved Nonylphenol-Induced Memory Deficit and Neurotoxicity Trough its Antioxidant and Neuroprotective Effects

Thymoquinone Improved Nonylphenol-Induced Memory Deficit and Neurotoxicity Trough its Antioxidant and Neuroprotective Effects

Hospital-based case control study and animal study on the relationship between nonylphenol exposure and depression

Ameliorative effect of Alpinia officinarum Hance extract on nonylphenol‐induced reproductive toxicity in male rats

Contact Info

Product

Resources

About