The correlation between monocyte chemoattractant protein-1 and the arthritis of systemic lupus erythematosus among Chinese

Ye, Dong‐Qing; Hu, Yuzhen; Li, Xiang Pei; Yang, Shuo; Hao, Jia; Huang, Fen; Zhang, Xue Jun

doi:10.1007/s00403-004-0531-y

Cited by 36 publications

(34 citation statements)

References 29 publications

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“…But on the other hand, our results matched studies by Ye et al, Warchol et al, and Lian LH who had genotyped the CXCL12-3′G801A polymorphism in Chinese, Poland, and Malaysian subjects, respectively, and found no association of CXCL12-3′G801A polymorphism with SLE (Ye et al 2005;Warchol et al 2010;Lian et al 2011).…”

Section: Discussionsupporting

confidence: 92%

SDF-1(CXCL12) polymorphisms in Egyptian patients with systemic lupus erythematosus (SLE): a pilot study

et al. 2015

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SDF-1(CXCL12) is a chemokine that plays an important role in the regulation of migration, proliferation, and differentiation of hematopoietic cells, as well as being involved in the homeostatic and inflammatory traffic of leukocytes. It was suggested that CXCL12 is a key molecule in the development of autoimmunity in the murine model of lupus. It has been demonstrated that SDF-1 has a G801A transition at position 801 in the 3′-untranslated region of the transcript, known as SDF-1-3′G801A. This polymorphism may have an important regulatory function via an increase in the biosynthesis of SDF-1 protein and has been reported in association with autoimmune diseases, such as type 1 diabetes and systemic sclerosis. We investigated the prevalence of SDF-1-3′ G801A genotype in Egyptian patients with systemic lupus erythematosus (SLE) (n=50) and healthy controls (HC) (n= 50) and its relation to SLE manifestations. We found a significant correlation between the SDF-1-3′G801A genotype and the following SLE features: photosensitivity, nephritis, serositis, and vasculitis, and also anticardiolipin antibodies. Our observations suggest that the SDF-1-3′-G801A genotype may be associated with some clinical and laboratory manifestations in patients with SLE.

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Section: Discussionsupporting

confidence: 92%

SDF-1(CXCL12) polymorphisms in Egyptian patients with systemic lupus erythematosus (SLE): a pilot study

et al. 2015

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“…Worldwide figures indicate a frequency of 64 % amongst the Chinese, Japanese and Koreans; 47 % amongst the Asians and lower frequencies of 21 % amongst the Hispanics and Afro-American populations. Our figures are comparable to those of Chinese amongst the Northeastern population that could probably be attributed to their Tibeto-Burman origin [29].…”

Section: Discussionsupporting

confidence: 80%

The Distribution of CCR2-64I, SDF1-3′A and MCP1-2518 G/A Genes Polymorphism in a Specific High Risk Group from the Northeastern States West Bengal, and Gorkha Population in India

Roy

Chakrabarti

2012

Indian J. Virol.

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We studied the prevalence and effects of host genetic polymorphisms for the three AIDS restriction genes (ARGs) namely CCR2-64I, SDF1-3 0 A and MCP1-2518 G/A for HIV infection and progression to AIDS using PCR-RFLP analysis on a total of 568 HIV seronegative serum samples collected from a specific high risk and young population hailing from the seven Northeastern states of India (n = 346), West Bengal (n = 96) and Gorkha population (n = 101). In addition, 181 HIV seropositive cases of which 92 inpatient cases in a large tertiary care hospital located at Kolkata were included in the study. HIV prevalence in our study group was 0.52 %. Four cases seroconverted, 25 cases progressed to AIDS and 05 died during the follow up period of 41 months. The genotype percentage of CCR2-64I, SDF1-3 0 A and MCP1-2518 G/A in the Northeastern states were 18.5, 40.3 and 54 % respectively in the seronegative population. Allele frequencies for SDF1-3 0 A in Northeastern states were significantly higher as compared to the Gorkha (21 %) and the North Indian population (24 %). Relative Hazard values were more than 0.9 for progression to AIDS and death. KaplanMeier survival analysis using Cox proportional regression model did not reveal any

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“…Amplification of the promoter region of the RANTES gene was carried out via PCR with primers, as described in a previous study (Ye et al, 2005a). The 20-µL amplification reaction contained 10 ng genomic DNA, 2 µL 10X Taq buffer with KCl, 1.5 mM MgCl 2 , 0.075 mM dNTP mixture, 0.375 µM of each forward and reverse primers, and 0.75 U Taq DNA polymerase.…”

Section: Amplification Of the Rantes Genementioning

confidence: 99%

“…One of the SNPs that is present at position 28 in the promoter region of the RANTES gene, has a cytosine (C) to guanine (G) variation. This polymorphism is proposed to elevate the promoter activity of RANTES, increasing the expression of RANTES in humans (Ye et al, 2005a).…”

Section: Introductionmentioning

confidence: 99%

Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population

Lh¹,

Kee²,

Hl³

et al. 2011

Genet. Mol. Res.

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ABSTRACT. Regulated on activation, normal T-cell expressed and secreted (RANTES) and stromal cell-derived factor 1 (SDF-1) are members of the CC-and CXC-chemokine families, respectively. Both genes have been postulated to be involved in the pathogenesis of systemic lupus erythematosus (SLE). We analyzed position 28 of the RANTES gene promoter region, as well as the SNP observed in the 3' UTR of the SDF-1 gene at position 801, in 130 patients presenting SLE at the Malaya University Medical Centre. Screening of 130 healthy volunteer controls using RFLP was also performed. RANTES-28 polymorphism analysis showed no significant (P = 0.3520) relationship, even though homozygous C/C was more frequent in SLE patients (OR = 1.4183) and heterozygous C/G was more frequent in healthy controls (OR = 0.7051). There were no significant (P = 0.2650) associations between A/A (OR = 0.783), G/G (OR = 1.5914) and G/A (OR = 0.8289) genotypes in the SDF-1 gene polymorphism with SLE. We conclude that there is no significant association of RANTES-28 and SDF-1 gene polymorphisms and occurrence of SLE in Malaysia.

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The correlation between monocyte chemoattractant protein-1 and the arthritis of systemic lupus erythematosus among Chinese

Cited by 36 publications

References 29 publications

SDF-1(CXCL12) polymorphisms in Egyptian patients with systemic lupus erythematosus (SLE): a pilot study

SDF-1(CXCL12) polymorphisms in Egyptian patients with systemic lupus erythematosus (SLE): a pilot study

The Distribution of CCR2-64I, SDF1-3′A and MCP1-2518 G/A Genes Polymorphism in a Specific High Risk Group from the Northeastern States West Bengal, and Gorkha Population in India

Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population

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