The correlation between lipoprotein ratios and hearing outcome in idiopathic sudden sensorineural hearing loss patients

Lin, Hung‐Che; Wang, C.-H.; Chou, Yu‐Ching; Shih, Cheng‐Ping; Chu, Yueng‐Hsiang; Lee, J.-C.; Chen, H.-C.

doi:10.1111/coa.12382

Cited by 21 publications

(17 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 17 The negative prognostic value of total cholesterol concentrations and of high LDL/HDL ratio have already been reported. 6 , 7 , 20 Lin et al . 21 provided evidence that comorbid diabetes or hypercholesterolemia may indicate a smaller probability of improvement for patients with SSHL, moreover a recent work by Jung et al .…”

Section: Discussionmentioning

confidence: 99%

Sudden sensorineural hearing loss: What factors influence the response to therapy?

et al. 2020

View full text Add to dashboard Cite

The standard treatment of Sudden Sensorineural Hearing Loss is based on oral steroids. In addition, intratympanic steroid is currently used in patients who fail to respond to oral treatment. The aim of the present study was to evaluate, in patients affected by SSHL, factors that influence the response to systemic and intratympanic steroid treatment. A retrospective analysis was conducted on 149 patients, all treated with systemic steroids. Moreover, patients not responsive to systemic therapy were treated with intratympanic steroids as salvage therapy. Auditory gain was assessed through the recovery rate at the discharge and after 30 days. Statistical analysis demonstrated that patients with delayed treatment and down-sloping auditory curve presented a poor recovery. Linear and stepwise regression showed that hypertriglyceridemia and hyperglycemia were negative prognostic factors. The prognosis of SSHL is affected by hyperglycemia and hypertriglyceridemia suggesting that a microvascular dysfunction within the cochlea could impair hearing recovery. Intratympanic steroid treatment was used as salvage treatment, however in patients with poor prognostic factors or at risk for side effects, it could be used in association with systemic treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Sudden sensorineural hearing loss: What factors influence the response to therapy?

et al. 2020

View full text Add to dashboard Cite

show abstract

“…2,15,26,27 Most researchers believed that a higher initial hearing threshold was an indicator of a poor prognosis in SSNHL patient, 2,15,26 but some studies failed to observe an association between initial hearing threshold and hearing improvement. 28 Moreover, Lin et al 21 said that comparisons between those reports must be treated with caution because of different recovery evaluation criteria. In our study, our results showed higher initial hearing threshold was significantly correlated with a poor prognosis by both Siegel's criteria and CMAO criteria which was in accord with most previous reports.…”

Section: Effect Of the Initial Hearing Threshold On Hearing Recoverymentioning

confidence: 99%

Effect of systemic lupus erythematosus and rheumatoid arthritis on sudden sensorineural hearing loss

Xie

Ning

She³

et al. 2019

The Laryngoscope

View full text Add to dashboard Cite

Objectives Recent reports have identified autoimmune systemic diseases as a significant risk factor for sudden sensorineural hearing loss (SSNHL). We investigated whether systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) were correlated with the hearing recovery of SSNHL. Study Design A retrospective study. Methods Records of 663 SSNHL patients between January 2008 and January 2019 were retrospectively reviewed, including demographic, comorbid diseases, and hearing recovery. Patients were divided into four groups (complete, partial, slight, and no recovery) according to Siegel's criteria and Chinese Medical Association of Otolaryngology (CMAO) criteria. Multinomial logistic regression was performed to evaluate the effects of onset of treatment, initial hearing threshold, audiogram pattern, diabetes mellitus, SLE, and RA on the prognosis of SSNHL according to both criteria. Results Patients in complete recovery, partial recovery, slight recovery, and no improvement were 95 (14.3%), 183 (27.6%), 170 (25.6%), and 215 (32.4%) by Siegel's criteria, and 90 (13.6%), 152 (22.9%), 188 (28.4%), and 233 (35.1%) by CMAO criteria, respectively. Among the four groups, onset of treatment, initial hearing threshold, diabetes mellitus, SLE, RA, and profound audiogram pattern were found to be associated with recovery outcome by both Siegel's criteria and CMAO criteria (P < .05). According to analysis results, presence of SLE, RA, diabetes mellitus and higher initial hearing threshold were significantly correlated with a poor prognosis by both Siegel's criteria and CMAO criteria (P < .05). Conclusion Comorbid SLE or RA may negatively affect the prognosis of SSNHL. Lower initial hearing threshold and absence of diabetes mellitus are associated with favorable hearing recovery. Level of Evidence 4. Laryngoscope, 130:2475–2480, 2020

show abstract

“…Hyperlipemia is one of the risk factors of cardiovascular disease, which increases blood viscosity and alters vasomotion (9). Recent reports have identified hypercholesterolaemia as a significant risk factor for ISSNHL (10,11). A systematic review and meta-analysis of the relationship between serum lipids and ISSNHL did not provide evidence for the association between them, nor did it definitively rule out such an association (12).…”

Section: Introductionmentioning

confidence: 98%

Correlation between serum lipid and prognosis of idiopathic sudden sensorineural hearing loss: a prospective cohort study

Shao¹,

Xiong²,

Gao³

et al. 2021

Ann Transl Med

View full text Add to dashboard Cite

Background: To investigate the correlation between blood lipids and the prognosis of idiopathic sudden sensorineural hearing loss (ISSNHL).Methods: We included 232 patients with ISSNHL at the Second Affiliated Hospital of Shanghai University from June 2015 to March 2017 using a prospective cohort study design. We collected information including age, gender, hypertension, diabetes, mellitus, vertigo, as well as the levels of blood total cholesterol (TC), triglycerides (TG), and low-density lipoproteins (LDL-C). We also recorded the ratio between the levels of low-density lipoproteins and the levels of high-density lipoproteins (LDL-C/HDL-C ratio). Correlations between the prognosis of ISSNHL and TC, TG, LDL-C, and LDL-C/HDL-C ratio were analyzed by univariable and multivariable logistic regression analyses.

show abstract

The correlation between lipoprotein ratios and hearing outcome in idiopathic sudden sensorineural hearing loss patients

Abstract: We suggested that lipoprotein ratio of LDL-C/HDL-C may be a prognostic factor for hearing recovery in ISSNHL patients. Further studies should be conducted to determine whether hearing outcomes in ISSNHL can be improved by changing patients' lipid profiles via antilipidemic treatment.

Cited by 21 publications

References 23 publications

Sudden sensorineural hearing loss: What factors influence the response to therapy?

Sudden sensorineural hearing loss: What factors influence the response to therapy?

Effect of systemic lupus erythematosus and rheumatoid arthritis on sudden sensorineural hearing loss

Correlation between serum lipid and prognosis of idiopathic sudden sensorineural hearing loss: a prospective cohort study

Contact Info

Product

Resources

About