The Correlation between Gastric Emptying Time and the Response of GIP and Enteroglucagon to Oral Glucose in Duodenal Ulcer Patients

Lauritsen, K. B.; Frederiksen, Hans Jørgen; Uhrenholdt, A; Hup, J. J. Holst

doi:10.3109/00365528209182241

Cited by 12 publications

(6 citation statements)

References 21 publications

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“…Along with these results. Lauritsen et al [35] concluded that the increased insu lin response to glucose among duodenal ul cer patients may be explained by the in creased gastric emptying known to occur in these patients. All these data taken together suggest that the rate of glucose delivery into the intestine is of importance in the insulin response to oral stimuli (glucose or mixed meal).…”

Section: Discussionmentioning

confidence: 99%

Effect of Bombesin on Glucose-Induced Insulin Release in Humans

Scarpignato¹,

Gioffré²,

Micali³

1987

Digestion

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The effect of bombesin on basal and glucose-stimulated insulin release was studied in male healthy volunteers. Glucose was administered by oral, intravenous or intraduodenal route during saline or bombesin infusion (5 ng/kg/min for 60 min). The peptide had no significant effect on basal levels of glucose and insulin. However, during its administration, the insulin response and the expected rise in blood glucose after oral glucose load (50 g) were strongly inhibited, and the gastric emptying of liquids was significantly delayed. On the contrary, the insulin response to intravenous glucose (20 g) was significantly increased by bombesin without changes in plasma glucose levels. Finally, when glucose was infused into the duodenum, thus bypassing the stomach, the insulin response was significantly increased by the peptide. In this case, too, plasma glucose levels after glucose load were virtually identical during either bombesin or saline infusion. These data clearly demonstrate that the direct effect of bombesin on insulin release is stimulatory and suggest that the inhibitory effect observed after oral glucose is connected with the action of the peptide on gastric emptying, the delay of which slows the entry of glucose into the small bowel.

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Section: Discussionmentioning

confidence: 99%

Effect of Bombesin on Glucose-Induced Insulin Release in Humans

Scarpignato¹,

Gioffré²,

Micali³

1987

Digestion

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“…This makes us consider the participation of other gut hormones along with GIP in the entero-insular axis (Unger and Eisentraut 1969). In the lower intestine, the population of gut-GLI-secreting cells is greater than in the upper intestine (Ghatei and Bloom 1981), and gut-GLI release is stimulated by ingested glucose (Lauritsen et al 1982) or fat (Ohneda et al 1975). In our other study about dumping syndrome (as yet unpublished), the response curve of blood glucose after oral glucose loading was similar to that of the SV + A group, and the peak level of gut-GLI appeared at 30 or 60 min.…”

Section: Commentsmentioning

confidence: 99%

Influence of vagotomy upon GIP release in patients with peptic ulcer.

Imamura

Kameyama

Naitö

et al. 1984

Tohoku J. Exp. Med.

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Twenty-two vagotomized peptic ulcer patients were studied on the influence of vagotomy on the release of GIP. Moreover, the relationship between acid output and GIP release was analyzed. These patients underwent one of the three types of operation ; truncal vagotomy with pyloroplasty (TV +P) selective vagotomy with pyloroplasty (SV+P) and selective vagotomy with antrectomy (SV+A). Before and after surgery, a gastric juice study and an oral glucose tolerance test were performed on separate days. Maximum acid output in response to tetragastrin correlated significantly with integrated GIP response after oral glucose loading. In the SV+P group, the response of GIP was slightly greater after surgery. In the SV+A group, the integrated GIP response diminished postoperatively, although, after surgery, GIP reached its peak sooner. The integrated GIP response was greater in the SV + P group than in the TV + P group. The response of GIP was less in the SV + A group than in the SV+P group. These changes were insignificant. In conclusion, it is presumed that GIP release is affected by gastric acid, gastric emptying time, intestinal transit time and vagal nerve action.vagotomy ; gastric acid secretion ; gastric inhibitory polypeptide (GIP) ; insulin

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“…BAcH was measured using a 2, 4-dinitrophenylhydrazine (DNPH) derivative method for acetaldehyde by ultraviolet detection (365 nm) with a HPLC technique [15]. For estimating GER, we measured both blood glucose levels and gastric inhibitory polypeptide (GIP) of a glucose-dependent insulinotropic polypeptide, because the both parameters are commonly used as indirect methods for measuring GER in various studies [16][17][18][19][20][21]. Plasma glucose concentrations (PGC, mg/dl) were determined before (0 min) and at 30 min after drinking by a hexokinase method with a routine measurement in a clinical laboratory and ΔPGC (PGC 30 min − PGC 0 min ) was obtained (ΔPGC was used to evaluate nineteen subjects because the fasting PGC of only one subject was more than 126 mg/dl and was a diagnostic criteria of diabetes mellitus in Japan).…”

Section: Blood Analysesmentioning

confidence: 99%

Individual Differences in Blood Alcohol Concentrations after Moderate Drinking Are Mainly Regulated by Gastric Emptying Rate Together with Ethanol Distribution Volume

Oshima¹,

Haseba²,

Masuda³

et al. 2012

FNS

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Blood alcohol concentration (BAC) differs greatly among individuals, even when people of the same sex and age drink alcohol under the same drinking conditions. In this study, we investigated the main factors involved in the internal reg-ulation of individual differences in BAC, focusing on the alcohol dehydrogenase 1B (ADH1B) genotype, blood acetal-dehyde concentration (BAcH), amount of habitual alcohol consumption, pharmacokinetic parameters of BAC, distribution volume of ethanol (Vd), and gastric emptying rate (GER) under the same drinking conditions. Twenty healthy Japanese males aged between 40 and 59 years old and having the aldehyde dehydrogenase 2 (ALDH2) genotype of ALDH 2*1/*2 were recruited for this study. The subjects were given 0.32 g ethanol/kg body weight in the form of commercially available beer (5%, v/v). The results showed that BAC-max differed greatly among individuals with a more than two-fold variation. When the BAC-time curve was compared among ADH1B genotypes (ADH1B*1/*1, *1/*2, and *2/*2), there were no differences in BAC among the genotypes. Although BAcH, monthly alcohol consumption, elimination rate of blood ethanol (<i>β</i> value) and ethanol disappearance rate from the body (EDR) can affect BAC, all of them had no correlations with BAC-max. However, Vd (liter/kg), ΔPlasma glucose concentration (ΔPGC = PGC30 min ? PGC0 min) and the serum concentration of gastric inhibitory polypeptide (GIP) did correlate with BAC-max. Model 2 in multiple linear regression analysis showed the optimal model for Vd and GIP with positive correlations with BAC-max. As GIP and ΔPGC are both reflected by gastric emptying rate (GER), we concluded that the individual differences in BAC after moderate drinking are mainly regulated by GER together with Vd. These findings demonstrate that together with body water content, the gastrointestinal tract plays an important role in the regulation of individual differences in BAC, involving first pass metabolism of ethanol

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The Correlation between Gastric Emptying Time and the Response of GIP and Enteroglucagon to Oral Glucose in Duodenal Ulcer Patients

Cited by 12 publications

References 21 publications

Effect of Bombesin on Glucose-Induced Insulin Release in Humans

Effect of Bombesin on Glucose-Induced Insulin Release in Humans

Influence of vagotomy upon GIP release in patients with peptic ulcer.

Individual Differences in Blood Alcohol Concentrations after Moderate Drinking Are Mainly Regulated by Gastric Emptying Rate Together with Ethanol Distribution Volume

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