The correlation between blood levels of ibuprofen and clinical analgesic response

Abstract

A clinical trial comparing ibuprofen, 400, 600, and 800 mg, with aluminum ibuprofen, 400 mg, and placebo was conducted in patients with moderate or severe pain subsequent to third molar extraction. Pain intensity ratings and ibuprofen serum levels were obtained at baseline, 30 minutes, 1 hour, and hourly thereafter for 3 hours. Pain intensity ratings were also obtained at hours 4, 5, and 6. Serum levels at 1, 2, and 3 hours correlated significantly with the log dose of ibuprofen (r = 0.35, 0.49, and 0.48, respectively) and with global analgesic response as measured by the percentage of the sum of the pain intensity scores (r = 0.28, 0.34, and 0.26, respectively). However, possibly because of differences in drug formulation, the percentage of the sum of the pain intensity scores did not correlate significantly with log dose. The highest correlations were found between contemporaneous serum levels and pain intensity difference values, particularly at hour 1 (r = 0.54). Our results support the proposition that increased ibuprofen serum levels lead to increased analgesia.

Stereoselective disposition of ibuprofen enantiomers in infants.

“…In adults, a linear relationship between plasma ibuprofen concentration and the degree of pain relief was reported by Laska et al [15]. Since plasma concentrations of the active S isomer are low in infants relative to adults a higher dosage might be required in infants.…”

Simultaneous Determination of NSAID and Antimicrobial Preservatives Using Validated RP-HPLC Method: An Application in Pharmaceutical and Clinical Laboratories

“…Dexibuprofen is rapidly absorbed, and peak serum concentration is achieved within 1.5-2 hours of oral administration [6]. It has been established there is a significant correlation between serum Dexibuprofen levels and the resultant degree of pain relief, particularly 1 hour after administration [7]. Figure 1) and Sodium benzoate NaC 6 H 5 CO 2 are the well-known preservatives that are used primarily for their bactericidal and fungicidal properties.…”

Dose‐related effects of ibuprofen on pain‐related potentials.

“…Thus, the present study aimed to close this gap. Among NSAIDs ibuprofen was chosen as a potent analgesic the doserelated analgesic effects of which have been studied intensively in a clinical setting [5,6]. The present investigation included the testing of placebo and two doses of rac-ibuprofen (400 and 800 mg).…”