The correlation between biological activity and diffusion-weighted MR imaging and ADC value in cases with prostate cancer

Sökmen, Bedriye Koyuncu; Sökmen, Doğukan; Uçar, Neşe; Özkurt, Hüseyin; Şimşek, Abdülmuttalip

doi:10.4081/aiua.2017.4.277

Cited by 5 publications

(3 citation statements)

References 17 publications

(18 reference statements)

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“…We found a weak inverse correlation between SUVmax values and ADCmean values in metastatic lymph nodes. Inverse correlation was also reported previously for bone lesions and primary prostate lesions in prostate cancer [20,21]. Wetter et al found moderately significant inverse correlation between SUVmax and ADC values of metastatic bone lesions of prostate cancer [22].…”

Section: Discussionsupporting

confidence: 73%

Relationship Between SUVmax and ADC Values of Metastatic Lymph Nodes Detected by Ga-68 PSMA PET/MR in Prostate Cancer Patients

Aghazada¹,

Kibar²,

Beşli³

et al. 2022

Grand J Urol

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Objective: Our aim is to assess if there is a relationship between maximum standardized uptake (SUVmax) and apparent diffusion coefficient (ADC) values of reactive and metastatic lymph nodes, also to compare ADC values of reactive and metastatic lymph nodes in prostate cancer patients. Materials and Methods:We have retrospectively investigated 20 patients diagnosed with prostate cancer who underwent Ga-68 PSMA PET/MR imaging. Three metastatic and three reactive lymph nodes classified according to PSMA Ga-68 uptake in PET/MR were chosen for each patient. SUVmax and ADCmean values were calculated for each lymph node separately. SPSS version 22 was used for statistical analysis. Results: A total of 120 lymph nodes in 20 prostate cancer patients were assessed. There was a weak negative correlation between SUVmax values and ADCmean values of metastatic lymph nodes (p=0.009, r=-0.333). However, there was no significant correlation between SUVmax values and ADCmean values of reactive lymph nodes (p=0,271, r=-0,144). ADCmean values of metastatic lymph nodes were significantly lower than those of reactive lymph nodes (p=0.0001). Conclusion: PET/MR, which combines both advantages of PET and MRI, is an important tool for the diagnosis and management of prostate cancer. We have found that SUVmax values of metastatic lymph nodes were inversely correlated with ADCmean values and combination of both parameters may increase the diagnostic accuracy of Ga-68 PSMA PET/MR in the detection of lymph node metastasis.

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Section: Discussionsupporting

confidence: 73%

Relationship Between SUVmax and ADC Values of Metastatic Lymph Nodes Detected by Ga-68 PSMA PET/MR in Prostate Cancer Patients

Aghazada¹,

Kibar²,

Beşli³

et al. 2022

Grand J Urol

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“…We found higher SUV max and SUV mean values and lower ADC values in patients with LN metastasis, which may be due to the presence of more aggressive tumor with higher Gleason scores, that were documented to have both higher PSMA uptake and lower ADC values in the literature (26,27,34). Concomitant usage of SUV and ADC parameters by using the ratio of SUV/ADC further increased the sensitivity and specificity of PET/MRI imaging in predicting LN metastasis.…”

Section: Discussionmentioning

confidence: 67%

“…Ga-68 PSMA uptake was shown to be correlated with tumor Gleason score, serum PSA levels, PI-RADS category and DRE findings (25). ADC value obtained by mpMRI was also found to be correlated with Gleason scores (26,27), serum PSA levels (28), molecular markers (29) and was introduced to be a promising tool to monitor therapy response (30,31). To our knowledge, PSMA uptake and ADC values were not compared before using hybrid PET/MRI or PET/CT systems.…”

Section: Discussionmentioning

confidence: 99%

Correlation of SUV<sub>max</sub> and Apparent Diffusion Coefficient Values Detected by Ga-68 PSMA PET/MRI in Primary Prostate Lesions and Their Significance in Lymph Node Metastasis: Preliminary Results of an On-going Study

Uslu-Beşli¹,

Bakir²,

Asa³

et al. 2019

Mirt

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Objectives:Gallium-68 (Ga-68) prostate specific membrane antigen (PSMA) positron emission tomography (PET) has been shown to be more accurate than multiparametric prostate magnetic resonance imaging (MRI) in detection of primary prostate lesions. Using hybrid PET/MRI we aim to detect the correlation between SUVmax and apparent diffusion coefficient (ADC) in primary prostate lesions and to assess their prognostic value in detection of lymph node (LN) metastasis.Methods:Twenty-six patients, who were diagnosed as having prostate cancer with biopsy and underwent Ga-68 PSMA PET/MRI together with biparametric prostate MRI (bpMRI) were included. SUVmax, SUVmean and ADC were recorded for index lesions drawing a region of interest (ROI) of 1 cm2 around the pixel with the highest SUVmax (ROI-1) and another ROI following borders of prostate tumor detected by bpMRI (ROI-2). Presence of LN metastasis was recorded according to PSMA PET/MRI.Results:SUVmax was inversely correlated with ADC (ROI-1: p=0.010; ROI-2: p=0.017 for b=800). SUVmax and SUVmeans were both higher in patients with LN metastasis and ADC was lower in patients with LN metastasis for ROI-1. SUVmax cut-off value of 19.8 for ROI-1 and 20.9 for ROI-2 had sensitivity and specificity of 77.8% and 76.5%, respectively for detection of LN metastasis, whereas ADC (b=800) cut-off value of 0.92x10-3 mm2/s had sensitivity and specificity of 87.5% and 76.5%, respectively. SUVmax/ADC (b=800) ratio increased the sensitivity and specificity to 100% and 82.4%, respectively.Conclusion:SUV and ADC values are inversely correlated in primary prostate lesions and the combined use of both values increases the diagnostic accuracy of hybrid PET/MRI in the detection of primary prostate lesions.

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Quantitative Imaging in Magnetic Resonance Imaging

Schmainda

2021

Quantitative Imaging in Medicine

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Magnetic resonance imaging (MRI) offers superior soft tissue contrast due to its unique dependence on tissue water magnetization and the access to user-defined variables. As such, MRI contrast can also made dependent on water diffusion rates, a capability unique to MRI, from which quantitative estimates of tissue water diffusion can be derived. Diffusion-weighted MRI (DWI) and diffusion tensor imaging MRI (DTI) MRI are the two primary methods available for this purpose, but many newer options are emerging. MRI contrast can be further enhanced by administration of MRI contrast agents, which are routinely used for the clear identification of disease. When dynamic MR images are acquired during the administration of exogenous MRI contrast agents, a perfusion-dependent MRI signal will result, from which tissue perfusion parameters can be derived. The two primary approaches used for this purpose are dynamic contrast-enhanced (DCE)-MRI and dynamic susceptibility contrast (DSC)-MRI. While qualitative assessment of structural, diffusion, and perfusion MRI images has positioned MRI solidly at the center of diagnostic imaging, the benefits of quantifying this information is becoming increasingly clear. This chapter describes the basic principles, applications to cancer, and challenges for quantification of structural MRI, diffusion-weighted imaging MRI, and perfusion-weighted imaging MRI techniques.

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The correlation between biological activity and diffusion-weighted MR imaging and ADC value in cases with prostate cancer

Cited by 5 publications

References 17 publications

Relationship Between SUVmax and ADC Values of Metastatic Lymph Nodes Detected by Ga-68 PSMA PET/MR in Prostate Cancer Patients

Relationship Between SUVmax and ADC Values of Metastatic Lymph Nodes Detected by Ga-68 PSMA PET/MR in Prostate Cancer Patients

Correlation of SUV<sub>max</sub> and Apparent Diffusion Coefficient Values Detected by Ga-68 PSMA PET/MRI in Primary Prostate Lesions and Their Significance in Lymph Node Metastasis: Preliminary Results of an On-going Study

Quantitative Imaging in Magnetic Resonance Imaging

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