Correlation of SUV&lt;sub&gt;max&lt;/sub&gt; and Apparent Diffusion Coefficient Values Detected by Ga-68 PSMA PET/MRI in Primary Prostate Lesions and Their Significance in Lymph Node Metastasis: Preliminary Results of an On-going Study

Uslu-Beşli, Lebriz; Bakir, Barış; Asa, Sertaç; Güner, Ekrem; Demirdağ, Çetin; Şahin, Onur Erdem; Karayel, Emre; Sağer, Sait; Sayman, Haluk; Sönmezoğlu, Kerim

doi:10.4274/mirt.galenos.2019.63825

Cited by 11 publications

(16 citation statements)

References 34 publications

(50 reference statements)

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“…The optimal time to acquisition is after 3–4 weeks post-ADT. Uslu-Besli et al [ 49 ] 2019 Turkey Retrospective 67.9 ± 7.0 26 65.2 ± 199.6 ng/mL Staging None 68Ga-PSMA-11 26 Imaging interpretation Correlation between SUVmax and ADC in the primary PCa. Bialek et al [ 50 ] 2019 Poland Retrospective 64.4 ± 7.07 89 NA Staging and restaging NA 68Ga-PSMA-11 89 Imaging interpretation Cervical sympathetic ganglia should not be falsely interpreted as laterocervical lymph nodes.…”

Section: Resultsmentioning

confidence: 99%

“…2 ). The risk of bias for patient selection was high in many papers [ 10 , 15 , 19 – 21 , 23 , 24 , 31 , 37 , 40 – 42 , 44 , 49 – 51 , 53 , 55 ]. The flow and timing were also high in 17 studies [ 10 , 15 , 20 – 24 , 26 , 27 , 31 , 32 , 35 , 44 , 45 , 51 – 53 ].…”

Section: Resultsmentioning

confidence: 99%

“…The flow and timing were also high in 17 studies [ 10 , 15 , 20 – 24 , 26 , 27 , 31 , 32 , 35 , 44 , 45 , 51 – 53 ]. The applicability of the studies was adequate in most cases, but unclear as regards the reference standard in 18 of them [ 15 , 22 – 24 , 27 , 34 – 37 , 41 – 44 , 49 , 50 , 52 , 53 , 56 ].

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Section: Resultsmentioning

confidence: 99%

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PET/MRI in prostate cancer: a systematic review and meta-analysis

Evangelista

Zattoni

Cassarino

et al. 2020

Eur J Nucl Med Mol Imaging

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Aim In recent years, the clinical availability of scanners for integrated positron emission tomography (PET) and magnetic resonance imaging (MRI) has enabled the practical potential of multimodal, combined metabolic-receptor, anatomical, and functional imaging to be explored. The present systematic review and meta-analysis summarize the diagnostic information provided by PET/MRI in patients with prostate cancer (PCa). Materials and methods A literature search was conducted in three different databases. The terms used were “choline” or “prostate-specific membrane antigen - PSMA” AND “prostate cancer” or “prostate” AND “PET/MRI” or “PET MRI” or “PET-MRI” or “positron emission tomography/magnetic resonance imaging.” All relevant records identified were combined, and the full texts were retrieved. Reports were excluded if (1) they did not consider hybrid PET/MRI; or (2) the sample size was < 10 patients; or (3) the raw data were not enough to enable the completion of a 2 × 2 contingency table. Results Fifty articles were eligible for systematic review, and 23 for meta-analysis. The pooled data concerned 2104 patients. Initial disease staging was the main indication for PET/MRI in 24 studies. Radiolabeled PSMA was the tracer most frequently used. In primary tumors, the pooled sensitivity for the patient-based analysis was 94.9%. At restaging, the pooled detection rate was 80.9% and was higher for radiolabeled PSMA than for choline (81.8% and 77.3%, respectively). Conclusions PET/MRI proved highly sensitive in detecting primary PCa, with a high detection rate for recurrent disease, particularly when radiolabeled PSMA was used.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Fig.…”

Section: Resultsmentioning

confidence: 99%

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PET/MRI in prostate cancer: a systematic review and meta-analysis

Evangelista

Zattoni

Cassarino

et al. 2020

Eur J Nucl Med Mol Imaging

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“…In this study, the ADC value negatively correlated with SUV max , which was consistent with previous studies. [ 25 , 26 ] The SUV max /ADC ratio has been utilized to evaluate the combined advantages of MRI and PET/CT and showed great sensitivity and specificity for the detection of lymphadenopathy in PCa. [ 25 ] This study demonstrated PCa was associated with lower ADC, and higher SUV max and SUV max /ADC.…”

Section: Discussionmentioning

confidence: 99%

68Ga-PSMA-11 PET/CT combining ADC value of MRI in the diagnosis of naive prostate cancer

Wang¹,

Yu²,

Zang³

et al. 2020

Medicine

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68 Ga-PSMA-11 positron emission computed tomography /computed tomography (PET/CT) is more sensitive than magnetic resonance imaging (MRI) in detecting prostate cancer (PCa). We evaluated the value of 68 Ga-PSMA-11 PET/CT with MRI in treatment-naive PCa. This retrospective study was approved by the hospital ethics committee. The MRI and 68 Ga-PSMA-11 PET/CT imaging data of 63 cases of highly suspected PCa were enrolled in this study. The SUV max and apparent diffusion coefficient (ADC), and their ratio, were assessed as diagnostic markers to distinguish PCa from benign disease. There were 107 prostate lesions detected in 63 cases. Forty cases with 64 malignant primary lesions were confirmed PCa, whereas 23 cases had 43 benign lesions. PSMA-avid lesions correlated with hypointense signal on ADC maps and hyperintense signal on diffusion-weighted imaging. The ADC of PCa was lower than that of benign lesions, and SUV max and SUV max /ADC of PCa was higher than that of benign lesions ( P < .01). ADC had significant negative correlation with Gleason score (GS) and SUV max , SUV max , and SUV max /ADC positively correlated with GS. From ROC analysis, we established cutoff values of ADC, SUV max , and SUV max /ADC at 1.02 × 10 −3 mm 2 /s, 11.72, and 12.35, respectively, to differentiate PCa from benign lesions. The sensitivity, specificity, and AUC were 90.6%, 58.1%, and 0.816 for ADC, 67.2%, 97.7%, and 0.905 for SUV max , and 81.2%, 88.4%, and 0.929 for SUV max /ADC, respectively. 68 Ga-PSMA-11 PET/CT combined with MRI offers higher diagnostic efficacy in the detection of PCa than either modality alone.

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“…Uslu-Besli et al demonstrated that SUV and ADC values are inversely correlated in primary prostate lesions. They combined both values' usage to increase the diagnostic accuracy of hybrid PET/MRI in the detection of primary prostate lesions and lymph node metastasis [ 27 ]. Park et al studied patients with intermediate- or high-risk cancer.…”

Section: Discussionmentioning

confidence: 99%

Lesion-to-background ratio threshold value of SUVmax of simultaneous [68Ga]Ga-PSMA-11 PET/MRI imaging in patients with prostate cancer

et al. 2020

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Purpose This study aimed to calculate an applicable relative ratio threshold value instead of the absolute threshold value for simultaneous 68Ga prostate-specific membrane antigen/positron emission tomography ([68Ga]Ga-PSMA-11 PET) in patients with prostate cancer (PCa). Materials and methods Our study evaluated thirty-two patients and 170 focal prostate lesions. Lesions are classified into groups according to Prostate Imaging Reporting and Data System (PI-RADS). Standardized uptake values maximum (SUVmax), corresponding lesion-to-background ratios (LBRs) of SUVmax, and LBR distributions of each group were measured based on regions of interest (ROI). We examined LBR with receiver operating characteristic analysis to determine threshold values for differentiation between multiparametric magnetic resonance imaging (mpMRI)-positive and mpMRI-negative lesions. Results We analyzed a total of 170 focal prostate lesions. Lesions number of PI-RADS 2 to 5 was 70, 16, 46, and 38. LBR of SUVmax of each PI-RADS scores was 1.5 (0.9, 2.4), 2.5 (1.6, 3.4), 3.7 (2.6, 4.8), and 6.7 (3.5, 12.7). Based on an optimal threshold ratio of 2.5 to be exceeded, lesions could be classified into MRI-positive lesion on [68Ga]Ga-PSMA PET with a sensitivity of 85.2%, a specificity of 72.0%, with the corresponding area under the receiver operating characteristic curve (AUC) of 0.83, p < 0.001. This value matches the imaging findings better. Conclusion The ratio threshold value of SUVmax, LBR, has improved clinical and research applicability compared with the absolute value of SUVmax. A higher threshold value than the background’s uptake can dovetail the imaging findings on MRI better. It reduces the bias from using absolute background uptake value as the threshold value.

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Correlation of SUV<sub>max</sub> and Apparent Diffusion Coefficient Values Detected by Ga-68 PSMA PET/MRI in Primary Prostate Lesions and Their Significance in Lymph Node Metastasis: Preliminary Results of an On-going Study

Cited by 11 publications

References 34 publications

PET/MRI in prostate cancer: a systematic review and meta-analysis

PET/MRI in prostate cancer: a systematic review and meta-analysis

68Ga-PSMA-11 PET/CT combining ADC value of MRI in the diagnosis of naive prostate cancer

Lesion-to-background ratio threshold value of SUVmax of simultaneous [68Ga]Ga-PSMA-11 PET/MRI imaging in patients with prostate cancer

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