The Cornea in Measles

Dekkers, N. W. H. M.

doi:10.1007/978-94-009-8677-0

Cited by 7 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During measles infection, MeV can be localized in ocular tissue [ 124 ] and its genomic RNA is detected in tear samples [ 125 ]. Detection of MeV antigen in epithelial cells within measles-associated conjunctival lesions was also reported previously [ 120 , 123 ]. In biopsies without conjunctival lesions, the antigen was only detected in the subepithelial tissue [ 120 ].…”

Section: Clinically Relevant Molecular Applications Of Conjunctival Nasolacrimal and Nasal 3d Cell Culture Modelssupporting

confidence: 78%

“…Conjunctivitis and coryza are hallmarks of measles [ 116 ] and shedding via the nasal mucosa is assumed to contribute to the high transmissibility of the virus [ 121 ]. Clinically, an ocular infection with MeV is thought to be acquired following viremia, leading to conjunctivitis and epithelial keratitis [ 122 , 123 ]. Measles infection is a major cause of childhood blindness in unvaccinated individuals, particularly in malnourished children [ 111 ].…”

Section: Clinically Relevant Molecular Applications Of Conjunctival Nasolacrimal and Nasal 3d Cell Culture Modelsmentioning

confidence: 99%

See 1 more Smart Citation

The Communication between Ocular Surface and Nasal Epithelia in 3D Cell Culture Technology for Translational Research: A Narrative Review

Aydin

Dietrich

Witt

et al. 2021

IJMS

View full text Add to dashboard Cite

There is a lack of knowledge regarding the connection between the ocular and nasal epithelia. This narrative review focuses on conjunctival, corneal, ultrastructural corneal stroma, and nasal epithelia as well as an introduction into their interconnections. We describe in detail the morphology and physiology of the ocular surface, the nasolacrimal ducts, and the nasal cavity. This knowledge provides a basis for functional studies and the development of relevant cell culture models that can be used to investigate the pathogenesis of diseases related to these complex structures. Moreover, we also provide a state-of-the-art overview regarding the development of 3D culture models, which allow for addressing research questions in models resembling the in vivo situation. In particular, we give an overview of the current developments of corneal 3D and organoid models, as well as 3D cell culture models of epithelia with goblet cells (conjunctiva and nasal cavity). The benefits and shortcomings of these cell culture models are discussed. As examples for pathogens related to ocular and nasal epithelia, we discuss infections caused by adenovirus and measles virus. In addition to pathogens, also external triggers such as allergens can cause rhinoconjunctivitis. These diseases exemplify the interconnections between the ocular surface and nasal epithelia in a molecular and clinical context. With a final translational section on optical coherence tomography (OCT), we provide an overview about the applicability of this technique in basic research and clinical ophthalmology. The techniques presented herein will be instrumental in further elucidating the functional interrelations and crosstalk between ocular and nasal epithelia.

show abstract

Section: Clinically Relevant Molecular Applications Of Conjunctival Nasolacrimal and Nasal 3d Cell Culture Modelssupporting

confidence: 78%

Section: Clinically Relevant Molecular Applications Of Conjunctival Nasolacrimal and Nasal 3d Cell Culture Modelsmentioning

confidence: 99%

The Communication between Ocular Surface and Nasal Epithelia in 3D Cell Culture Technology for Translational Research: A Narrative Review

Aydin

Dietrich

Witt

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…A change in hospital referrals, construction of new eye hospitals, or admission criteria might also be contributing factors, however, total admissions and total pediatric admissions did not change during the same period of time. Children with measles infection are at higher risk of blinding xerophthalmia [8], and recently it has been demonstrated that high dose vitamin A supplementation reduces morbidity, mortality, and ocular complications of measles [8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

The decline of admissions for xerophthalmia at Cicendo Eye Hospital, Indonesia, 1981?1992

Semba

Susatio²,

Natadisastra

et al. 1995

Int Ophthalmol

View full text Add to dashboard Cite

Xerophthalmia due to vitamin A deficiency is a leading cause of blindness in children and has been a serious problem in Indonesia. To determine whether progress has been made in the eradication of xerophthalmia, we assessed hospital admissions for xerophthalmia at Cicendo Eye Hospital, Bandung, Indonesia. The hospital admission registry from 1981 to 1992 was reviewed. Between January 1981 and December 1992, there were 117 admissions for xerophthalmia, and of these, 63 were boys and 54 were girls, with an average age of 3.9 +/- 0.3 years. Hospital admissions for xerophthalmia declined steeply from 1981 to 1985, with a few rare cases from 1985 through 1992. During the same period from 1981 through 1992, there were no overall changes in total hospital admissions or total pediatric admissions. These results suggest that xerophthalmia is becoming less common in Indonesia.

show abstract

“…In North Ghana the risk factors in 397 patients were: a disc excavation of more than 60%, intra-ocular pressure of more than 28 mmHg, or unexplained visual field loss [27]. This disease has been studied recently by various Dutch investigators (Eykman, Oomen, Kusin, Ten Doesschate [28], Sauter [29], Dekker [30], Pepping [31], Van Agtmaal [32], Bloem [33]). The WHO has also concentrated on the vitamin A problem [34][35][36][37][38].…”

Section: T R a C H O M Amentioning

confidence: 99%

“…Corneal scars usually occur after a corneal ulcer [57][58][59], measles [30], xerophthalmia and perforating trauma [60]. Fungi are found to be the cause of keratitis in 25% of patients [61][62][63].…”

Section: T R a C H O M Amentioning

confidence: 99%

Points of action in the campaign against blindness in developing countries

et al. 1991

View full text Add to dashboard Cite

This article provides a survey of the problems of prevention of blindness in developing countries. The World Health Organization estimates that 31 million people are blind and 15 million people partially-sighted. The main cause of blindness is cataract. Other causes are trachoma, glaucoma, xerophthalmia, river blindness, corneal scars and leprosy. Prevention or treatment of these causes is possible in more than 80% of cases. The number of blind persons, however, is still increasing due to the increase in population and the immense shortage of all kinds of ophthalmological equipment and personnel. An effective strategy for the prevention of blindness in developing countries should focus on: more cheap cataract operations, increasing teaching facilities for ophthalmic personnel, integration of ophthalmic care into the general health system and the promotion of blindness prevention in political organizations.

show abstract

The Cornea in Measles

Cited by 7 publications

References 0 publications

The Communication between Ocular Surface and Nasal Epithelia in 3D Cell Culture Technology for Translational Research: A Narrative Review

The Communication between Ocular Surface and Nasal Epithelia in 3D Cell Culture Technology for Translational Research: A Narrative Review

The decline of admissions for xerophthalmia at Cicendo Eye Hospital, Indonesia, 1981?1992

Points of action in the campaign against blindness in developing countries

Contact Info

Product

Resources

About