The Coombs' Test and the Acquired Immunodeficiency Syndrome

Gupta, Sudhir; Licorish, Kenrick

doi:10.7326/0003-4819-100-3-462_1

Cited by 11 publications

(2 citation statements)

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“…Production of autoantibodies has been reported in a number of different infectious diseases (Abu-Shakra & Schoenfeld 1991), and autoantibodies against RBC have been reported in AIDS (Gupta & Licorish 1984), tuberculosis (Murray 1978), trypanosomiasis (Assoku & Gardiner 1989), viral lymphocytic choriomeningitis (Vella & Pfau 1991) and babesiosis (Matsuda, Hasegawa & Kozaki 1987). Consistent with these findings, this report shows that antibodies can be eluted from RBC of mice infected with S. mansoni.…”

Section: Discussionsupporting

confidence: 82%

“…In other chronic infectious diseases, anti-RBC antibodies have been suggested or shown to play a role in anaemia by participating in, depending on the isotype of antibody induced, either complement or macrophagedependent RBC elimination (Gupta & Licorish 1984, Murray 1978, Assoku & Gardiner 1989, Vella & Pfau 1991, Matsuda, Hasegawa & Kozaki 1987. Elucidation of the role for the immune system in anaemia is complicated by the fact that anti-RBC antibodies contribute to normal RBC management (Kay 1991).…”

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confidence: 99%

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Increased CD4⁺ T cell‐dependent anti‐erythrocyte antibody levels following the onset of parasite egg production in Schistosoma mansoni infected mice

Humphries

Vella

Pearce

1994

Parasite Immunology

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Anaemia has been reported to be a symptom of schistosomiasis mansoni. In other chronic infectious diseases, anti-red blood cell (RBC) antibodies have been suggested or shown to play a role in anaemia by participating in either complement or macrophage-dependent RBC elimination. To examine whether such a situation could be contributing to the anaemia of schistosomiasis, we examined RBC taken from infected mice for surface-bound antibodies. Our data show that prior to the onset of egg production infected mice have plasma haemoglobin levels that are indistinguishable from age matched controls (AMC). However, consistent with previous reports, following the initiation of egg laying, infected mice have significantly lower haemoglobin levels than AMC. Surface-bound IgM, IgG1 and IgG3 on RBC from infected mice increased markedly after egg laying began. Levels of RBC-associated IgG2b were similar on RBC from infected and normal mice. Antibody production against RBC was Th cell-dependent since it did not occur in mice depleted of CD4+ cells. Antibodies eluted from RBC of infected mice bound to isolated membranes of RBC from AMC and to a soluble extract of schistosome eggs. Furthermore, antibodies in serum from mice carrying patent infections bound to the membranes of RBC from normal mice. Taken together, these data suggest that schistosome eggs induce an antibody response which may cross react with a RBC surface antigen.

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Section: Discussionsupporting

confidence: 82%

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confidence: 99%

Increased CD4⁺ T cell‐dependent anti‐erythrocyte antibody levels following the onset of parasite egg production in Schistosoma mansoni infected mice

Humphries

Vella

Pearce

1994

Parasite Immunology

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Immune complexes in the acquired immunodeficiency syndrome (AIDS): Relationship to disease manifestation, risk group, and immunologic defect

et al. 1985

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Immune complex assays (and other immunologic tests) were performed on sera from 162 patients with the acquired immunodeficiency syndrome (AIDS) and 275 AIDS-related subjects. Immune complexes were detected in 89% of AIDS patients and 93% of homosexual men with lymphadenopathy. Immune complex levels in AIDS patients were not associated with a particular risk group or with types of opportunistic infection or malignancy; however, they correlated with other laboratory features of the immune defect (depression in T helper cells and T helper/suppressor-cell ratio, and IgG levels). Immune complexes were also detected in a lesser proportion of risk-group controls (homosexual men, hemophiliacs, Haitians). In risk-group controls, immune complex levels were associated with certain features reflecting sexual practice, blood product exposure, or infection, but these features did not account for the higher levels found in AIDS patients. In appropriate situations, immune complex assays may be of value as screening tests or, possibly, as prognostic indicators for AIDS or AIDS-related syndromes.

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Malignant melanoma in a homosexual man with HTLV-III/LAV exposure

Gupta¹,

Imam²

1987

The American Journal of Medicine

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The Coombs' Test and the Acquired Immunodeficiency Syndrome

Cited by 11 publications

References 2 publications

Increased CD4⁺ T cell‐dependent anti‐erythrocyte antibody levels following the onset of parasite egg production in Schistosoma mansoni infected mice

Increased CD4⁺ T cell‐dependent anti‐erythrocyte antibody levels following the onset of parasite egg production in Schistosoma mansoni infected mice

Immune complexes in the acquired immunodeficiency syndrome (AIDS): Relationship to disease manifestation, risk group, and immunologic defect

Malignant melanoma in a homosexual man with HTLV-III/LAV exposure

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The Coombs' Test and the Acquired Immunodeficiency Syndrome

Cited by 11 publications

References 2 publications

Increased CD4+ T cell‐dependent anti‐erythrocyte antibody levels following the onset of parasite egg production in Schistosoma mansoni infected mice

Increased CD4+ T cell‐dependent anti‐erythrocyte antibody levels following the onset of parasite egg production in Schistosoma mansoni infected mice

Immune complexes in the acquired immunodeficiency syndrome (AIDS): Relationship to disease manifestation, risk group, and immunologic defect

Malignant melanoma in a homosexual man with HTLV-III/LAV exposure

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Product

Resources

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Increased CD4⁺ T cell‐dependent anti‐erythrocyte antibody levels following the onset of parasite egg production in Schistosoma mansoni infected mice

Increased CD4⁺ T cell‐dependent anti‐erythrocyte antibody levels following the onset of parasite egg production in Schistosoma mansoni infected mice