The conversion of 17α-hydroxyprogesterone into pregn-4-en-3α,17α-diol-20-one and other substances by perfusions through bovine adrenals and ovaries

Levy, Harold; Saito, Taiichi; Takeyama, Shoichi; Merrill, Anne P.; Schepis, J.P; Porter, Gina; Fitts, Michelle

doi:10.1016/0006-3002(63)91251-4

Cited by 18 publications

(1 citation statement)

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“…Ringold, Ramachandran & Forchielli (1962) reported the reduction of 6/?-fluorotestosterone by supernatant fractions of male rat liver to the corresponding 3-hydroxysteroids, and Levy, Saito, Takeyama, Merrill & Schepis (1963) obtained 3a,17a-dihydroxypregn-4-en-20-one from perfusion of 17a-hydroxyprogesterone through bovine adrenals and ovaries. As suggested by Levy et al (1963), rearrangement of a A4-3-hydroxysteroid to form a A5-3-hydroxysteroid would constitute a reversal of the oxidation of a A5-3-hydroxy to a A4-3-oxosteroid.…”

Section: Discussionmentioning

confidence: 97%

Steroid Biosynthesis 'In Vitro' by Granulosa-Theca Cell Tumour Tissue

Griffiths¹,

Grant²,

Symington³

1964

Journal of Endocrinology

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The metabolism of [4-14C]progesterone and [4-14C]androst-4-ene-3,17-dione (androstenedione) by a granulosa-theca cell tumour of the ovary, 310 g. in weight, removed from a 43-year-old post-menopausal woman has been studied in vitro.The experiments provided no evidence that the tumour could utilize progesterone as an oestrogen precursor. However, the tumour tissue converted androstenedione to oestrone and oestradiol-17\g=b\. The major metabolite of progesterone was 20\g=a\-hydroxypregn-4-en-3-one.These results are discussed in relation to current theories of the synthesis of steroids in the ovary.

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Section: Discussionmentioning

confidence: 97%