The Convergence of Two Epidemics: Vitamin D Deficiency in Obese School-aged Children

Cheng, L.

doi:10.1016/j.pedn.2017.10.005

Cited by 23 publications

(25 citation statements)

References 35 publications

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“…The results of the study have showed that the prevalence of vitamin D deficiency in adolescents is significant and as prevalent as in many other countries 2,3,12 . It has been established that there is an inverse relationship between the serum level of 25 (OH) D and the body mass index in adolescents.…”

Section: Discussionmentioning

confidence: 90%

“…Vitamin D deficiency leads to a decrease in calcium concentration in the blood, impairment of calcium and phosphorus absorption in the intestines and kidneys, because of its active metabolite 1,25-dihydroxyvitamin D 1 . It has been shown that vitamin D endocrine system affects electrolytes concentration, cell proliferation, angiogenesis, stimulation of insulin synthesis, inhibition of renin secretion [2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Peculiarities of the prevalence and risk factors for vitamin D deficiency in overweight and obese adolescents in Ukraine

SHULHAI¹,

Pavlyshyn²,

SHULHAI³

2019

Arch Balk Med Union

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Peculiarities of the prevalence and risk factors for vitamin D deficiency in overweight and obese adolescents in Ukraine

SHULHAI¹,

Pavlyshyn²,

SHULHAI³

2019

Arch Balk Med Union

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“…Vitamin D deficiency (VDD) and obesity are two global epidemics that are rising in the paediatric population with these two converging on each other where obesity has shown to a be strong risk factor for VDD and it emphasizes the need for more research to clarify the role of VDD on obesity and its related metabolic risks [17]. Dietary and life style changes could prevent VDD in obese children.…”

Section: Discussionmentioning

confidence: 99%

“…However, vitamin D supplementation is recommended for those with inadequate intake, for those with deficient vitamin D levels or for individuals who are symptomatic of VDD. Doses are based on whether VDD is being prevented or treated [17].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation in Obese Sri Lankan Children: A Randomized Controlled Trial

Samaranayake

Adikaram

Kendaragama

et al. 2020

Preprint

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Background Micronutrient deficiencies are identified among obese individuals. Vitamin D deficiency is prevalent in obese children, and is hypothesized to cause insulin resistance and metabolic abnormalities. This study aimed to determine the effect of vitamin D supplementation on obesity and related metabolic abnormalities among obese Sri Lankan children.Methods A triple-blind randomized controlled trial was conducted among vitamin D deficient (< 20 ng/ml), obese children (n = 96). Children were randomly allocated to three intervention arms - treatment arm receiving weekly vitamin D2 50,000 IU; supplementation arm receiving 2500 IU weekly and control arm receiving placebo. Anthropometry, percentage fat mass (%FM) and blood pressure were assessed and fasting blood glucose, fasting insulin, lipid profile, ALT, AST, vitamin D, parathyroid hormone and hs-CRP and OGTT with 2-hour random blood glucose and insulin was performed at baseline and after 24 weeks of treatment. Ethics Review Committee of Faculty of Medicine, University of Colombo approved the protocol.Results Waist circumference Z-score, %FM and serum calcium significantly improved across all three arms, ALT significantly improved in treatment and supplementation arms while, BMI Z-score, PTH and vitamin D significantly improved in the treatment arm. Biceps (p = 0.035) and subscapular (0.048) skin fold thickness, vitamin D (p = 0.004) and ALT (p = 0.012) significantly improved in the treatment arm.Conclusions A strict dietary and physical activity regimen could improve some of the anthropometric, body composition and metabolic profiles, but high dose vitamin D, enhances those improvements. Therefore high dose vitamin D seems to potentiate management outcomes of obese children with vitamin D deficiency.Trial registration The study was registered at the Sri Lanka Clinical Trials Registry (SLCTR/2015/017) on 12th September 2015 at https://slctr.lk/trials/slctr-2015-017.

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“…In the case of obesity as well as overweight, the deficiency of vitamin D increases, which greatly aggravates metabolic processes in the body. Vitamin D metabolites increase insulin sensitivity to insulin due to increased insulin receptor gene expression and decreased inflammatory cytokines [6,7].…”

Section: Introductionmentioning

confidence: 99%

Relation of carbohydrate exchange markers with vitamin D status in adolescents with overweight and obesity

Shulhai

Pavlyshyn

Shulhai

2019

pedm

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Introduction: In the case of obesity and excessive body weight, the deficiency of vitamin D increases, which significantly impairs metabolic processes in the body, especially fatty and carbohydrate metabolism. Vitamin D metabolites affect insulin sensitivity of cells. The aim of the study was to determine the relationship between vitamin D and carbohydrate metabolism in adolescents with excessive body weight and obesity. Material and methods: 139 adolescents were examined. The mean age of children was 15.5 ±2.3 years. 65 adolescents with excessive weight and 74 obesity teenagers were examined. Parameters that were determined in all children included: undertaking anthropometric measurements, general examinations, biochemical parameters, including carbohydrate metabolism: fasting glucose, insulin, oral glucose tolerant test, measuring the homeostasis model assessment for insulin resistance, blood pressure measurement and determination of vitamin D status. Results: The features of changes carbohydrate metabolism markers in adolescents with overweight and obesity, depending on the level of serum 25(OH)D, have been established. Correlations between vitamin D status and markers of carbohydrate metabolism such as basal insulin level (p = 0.000) and HOMA-IR index (p = 0.000) and anthropometric indices: body mass index (p = 0.000), waist circumference (p = 0.000) and hip circumference (p = 0.001), waist-hip ratio (p = 0.000), waist-to-height ratio (p = 0.000) have been determined. Conclusions: The study has established prognostically significant biochemical (basal insulin), and anthropometric (body mass index, waist circumference, waist-hip ratio, and waist-to-height ratio) markers resulting in vitamin D deficiency development in children with excessive body weight and obesity.

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The Convergence of Two Epidemics: Vitamin D Deficiency in Obese School-aged Children

Cited by 23 publications

References 35 publications

Peculiarities of the prevalence and risk factors for vitamin D deficiency in overweight and obese adolescents in Ukraine

Peculiarities of the prevalence and risk factors for vitamin D deficiency in overweight and obese adolescents in Ukraine

Vitamin D Supplementation in Obese Sri Lankan Children: A Randomized Controlled Trial

Relation of carbohydrate exchange markers with vitamin D status in adolescents with overweight and obesity

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