The Controversial Role of IL-33 in Lung Cancer

Yang, Keshan; Tian, Cuihua; Zhang, Chengliang; Xiang, Ming

doi:10.3389/fimmu.2022.897356

Cited by 7 publications

(4 citation statements)

References 107 publications

(113 reference statements)

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“…Drugs targeting VEGFA are effective and safe for the clinical management of MPE ( 21 ). Among the interleukins, the alarmin IL - 33 induces several factors that activate NF -κ B , JNK , ERK , and p3 8, eventually leading to the expression of cytokines, chemokines, and growth factors ( 55 ). Overexpression of leukemia inhibitory factor ( LIF ) is linked to the characteristics of aggressive tumors including lymph node metastasis and progression and increases STAT3 phosphorylation ( 56 ).…”

Section: Discussionmentioning

confidence: 99%

Expression of cytokines in pleural effusions and corresponding cell lines of small cell lung cancer

Rath,

Stickler,

Hochmair

et al. 2024

Transl Lung Cancer Res

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Background Small cell lung cancer (SCLC) is a neuroendocrine aggressive tumor with a dismal prognosis due to the lack of curative therapeutic modalities. Approximately 11% of these patients show a malignant pleural effusion (MPE) that increase in frequency with progression of the disease. In MPE, fluid accumulates due to leaky vessels and mesothelial surfaces as well as impaired removal of fluid due to impaired drainage. Methods For this investigation, three SCLC MPE samples and supernatants of the corresponding isolated cell lines were analyzed for the content of 105 cytokines, chemokines, and growth factors. Overexpressed pathways including these cytokines were identified using Reactome analysis tools. Results A large range of cytokines, including vascular endothelial growth factor A ( VEGFA ), were found to be expressed in the MPEs and conditioned media of the corresponding cell line. These mediators are involved in pathways such as interleukin ( IL ) signaling, growth factor stimulation, modulation of cell adhesion molecules and proliferative cell signaling. Cytokine expression by the corresponding SCLC cell lines revealed the specific contributions of the tumor cells and included high expression of VEGFA , tumor-promoting factors and mediators exerting immunosuppressive and protumor effects. MPEs used here showed marked stimulation of the proliferation of four permanent SCLC cell lines. Conclusions MPEs comprise a large number of cytokines with mixed activities on tumor cells and the invading SCLC cells release a number of protumor mediators and induce an immunosuppressive pleural environment.

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Section: Discussionmentioning

confidence: 99%

Expression of cytokines in pleural effusions and corresponding cell lines of small cell lung cancer

Rath,

Stickler,

Hochmair

et al. 2024

Transl Lung Cancer Res

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“…IL33 induces T cell proliferation and IL-17 secretion, thereby promoting antitumor effects in LUAD. IL33 expression is related to favorable survival in patients with LUAD [ 35 ]. BIRC3 mutation is associated with worse prognosis in chronic lymphocytic leukemia [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

A novel necroptosis signature for predicting survival in lung adenocarcinoma

Zang,

Wang,

Zhu

et al. 2023

BMC Med Genomics

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Background To explore the necroptosis-related genes (NRGs) signature and its predictive values in lung adenocarcinoma (LUAD). Methods The training cohort consisted of tumor samples from The Cancer Genome Atlas, and the validation set comprised data from the Gene Expression Omnibus. Univariate and multivariate Cox regression analyses were applied to identify the prognostic NRG signature as an independent molecular indicator. Correlation analysis was used for the association assessment between the NRG signature and immune checkpoint molecules. Results NRGs involved in necroptosis and immune NOD-like receptor signaling. The NRG signature based on eight NRGs can divide tumors into high-risk and low-risk groups, which was significantly associated with worse survival. Multivariate Cox regression analysis showed that this NRG signature remained an independent prognostic indicator. Stratification analyses demonstrated that this NRG signature was still effective for predicting survival in each stratum of age, gender, and tumor stage. The ROC curve showed a good predictive ability using the NRG signature in the validation cohort (AUC = 0.81). The NRG signature was related to immune checkpoint molecules PD − 1, PD-L1, and PD-L2. Conclusions The NRG signature could be a novel predictor of the prognosis and may become a potential therapeutic target in LUAD.

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“…IL‐33 plays also a multifaceted role in lung cancer (LCA), where its effects on the immune system exhibit both pro‐ and anti‐oncogenic properties(Yang et al 2022). Anti IL‐33 and anti ST2 have inhibitory effects on experimental cancer Treg cells (Wang et al 2017).…”

Section: Cytokine Il‐3(sil‐33)mentioning

confidence: 99%

Unpacking the complexity of nuclear IL-33 (nIL-33): a crucial regulator of transcription and signal transduction

Wang,

Tang

2023

J. Cell Commun. Signal.

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Small ubiquitin-related modifier USP21 Ubiquitin-specific peptidase 21 SMAD3 Smad family member 3 TSLP Thymic Stromal Lymphopoietin hBD2 Human beta-defensin 2 GATA3 GATA-binding protein 3 HDACs Histone deacetylases PARP1 (ADP-ribose) polymerase 1 ATM Ataxia-telangiectasia mutated BER Base excision repair DSB DNA double-strand break DDR DNA damage response DDIT3 DNA damage-inducible transcript 3 TNF-α Tumor necrosis factor-α,SASP,senescenceassociated secretory phenotype PROTACs Proteolysis-targeting chimeras DUBTACs Deubiquitinase targeting chimeras TPS Targeted protein stabilization SENP2 SUMO specific protease 2 Nanhong Tang

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The Controversial Role of IL-33 in Lung Cancer

Cited by 7 publications

References 107 publications

Expression of cytokines in pleural effusions and corresponding cell lines of small cell lung cancer

Expression of cytokines in pleural effusions and corresponding cell lines of small cell lung cancer

A novel necroptosis signature for predicting survival in lung adenocarcinoma

Unpacking the complexity of nuclear IL-33 (nIL-33): a crucial regulator of transcription and signal transduction

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