The contributions of miR-25-3p, oxidative stress, and heat shock protein in a complex mechanism of autophagy caused by pollutant cadmium in common carp (Cyprinus carpio L.) hepatopancreas

Li, Zhuo; Shah, Syed Waqas Ali; Zhou, Qin; Yin, Xiujie; Teng, Xiaohua

doi:10.1016/j.envpol.2021.117554

Cited by 58 publications

(15 citation statements)

References 59 publications

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“…Such as GSH Px, SOD, and CAT are antioxidant enzymes and MDA is the product of lipid peroxidation. Recent a study found that excess cadmium (Cd) decreased SOD and CAT, increased MDA, and caused common carp liver oxidative stress ( 4 ). Another study demonstrated that the down-regulation of GSH-Px, SOD, and CAT, as well as the up-regulation of MDA took part in Cd-induced oxidative stress; meanwhile the up-regulation of TNF-α and the down-regulation of IL-10 took part in Cd-induced immunosuppression in common carp gills ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of Probiotics on the Growth Performance, Antioxidant Functions, Immune Responses, and Caecal Microbiota of Broilers Challenged by Lipopolysaccharide

Zeng

et al. 2022

Front. Vet. Sci.

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We aimed to study the effects of dietary Bacillus coagulans (B. coagulans) and Lactobacillus plantarum (L. plantarum) on broilers challenged by Escherichia coli lipopolysaccharide (LPS). One-day-old Cobb 500 chicks (360) were divided randomly into three treatment groups for 47 days: no supplementation (control, CON), B. coagulans supplementation (BC), and L. plantarum supplementation (LA). Broilers were routinely fed for 42 days and intraperitoneally injected with 500 μg LPS per kg body weight at 43, 45, and 47 days of age, respectively. Samples were collected 3 h after the last injection. At 1–21 days of age, the ADG in the BC and LA groups was higher than that in the CON group, and the feed to gain ratio (F/G) in the BC group was significantly decreased (P < 0.05). Compared with that in CON birds, the ADG was increased and the F/G was decreased in the BC and LA birds at 22–42 and 1–42 days of age, respectively (P < 0.05). After LPS stimulation, the endotoxin (ET), diamine oxidase (DAO), and D-lactic acid (D-LA) levels in the BC group were lower than those in the CON group (P < 0.05). The IgY, IgA, and IgM contents in the BC group and the IgY and IgM contents in the LA group were higher than those in the CON group (P < 0.05). The pro-inflammatory factor and interferon-β (IFN-β) contents (P < 0.05) decreased, and the anti-inflammatory factor content in the serum (P < 0.05) increased in the BC and LA groups. Compared with the CON and LA treatments, the BC treatment increased the concentrations of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase (CAT), and decreased that of malondialdehyde (MDA) (P < 0.05). In contrast with the CON treatment, the BC and LA treatments increased the abundance of Ruminococcaceae and reduced that of Desulfovibrio (P < 0.05). Moreover, BC increased the abundance of beneficial bacteria. Overall, supplementation with B. coagulans and L. plantarum promoted the growth of broilers, improved their immunity and antioxidant capacity, and alleviated the LPS-stimulated inflammatory response by regulating the intestinal flora.

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Section: Introductionmentioning

confidence: 99%

Effects of Probiotics on the Growth Performance, Antioxidant Functions, Immune Responses, and Caecal Microbiota of Broilers Challenged by Lipopolysaccharide

Zeng

et al. 2022

Front. Vet. Sci.

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“…Some studies have shown that antibiotics can change the expression level and activity level of GST ( Savcı et al, 2020 ; Ayna et al, 2021 ). GST took part in excess toxic substance-induced poisoning mechanism in animals ( Li et al, 2021a ). GSTs can catalyze the binding of metabolites and accelerate the transport of the conjugates in cells.…”

Section: Discussionmentioning

confidence: 99%

Salvia miltiorrhiza polysaccharides alleviates florfenicol-induced liver metabolic disorder in chicks by regulating drug and amino acid metabolic signaling pathways

Liu

Liu²,

Fang³

et al. 2022

Poultry Science

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“…Total RNA of the colon tissue was extracted using TRIzol reagent in accordance with the manufacturer's instructions, and the RNA concentration and purity were assessed by absorbance at 260 nm and 280 nm 25 . A PrimeScript RT reagent kit (Takara, Shiga, Japan) was used to perform 10‐μL reverse transcription of RNA, and the TB green premix ex Taq Kit (Takara) was used to detect gene expression levels.…”

Section: Methodsmentioning

confidence: 99%

Rehmannia glutinosa polysaccharides attenuates colitis via reshaping gut microbiota and short‐chain fatty acid production

Dong

Cai

et al. 2022

J Sci Food Agric

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BACKGROUND Ulcerative colitis is a gastrointestinal disease closely related to intestinal epithelial barrier damage and intestinal microbiome imbalance; however, effective treatment methods are currently limited. Rehmannia glutinosa polysaccharide (RGP) is an important active ingredient with a wide range of pharmacological activities, although its protective effect on colitis remains to be explored. In the present study, we verified the in vitro anti‐inflammatory effect of RGP, and observed the ameliorating effect of RGP on dextran sulfate sodium‐induced colitis in mice. RESULTS The results showed that (i) RGP attenuates lipopolysaccharide‐induced overexpression of inflammatory factors in RAW264.7 cells; (ii) RGP improves the pathological damage caused by DSS, including weight loss, increased disease activity index and intestinal tissue ulcers; (iii) RGP improves tight junction proteins to protects the tightness of the intestinal epithelium; (iv) RGP inhibits the expression of inflammatory factors through the nuclear factor‐kappa B pathway, and improved the of intestinal tissues inflammation; and (v) RGP can maintain the species diversity of intestinal microbes, increase the content of short‐chain fatty acids and then restore the imbalance of intestinal microecology. CONCLUSION RGP can improve the intestinal microbiota to strengthen the intestinal epithelial barrier and protect against DSS‐induced colitis. © 2022 Society of Chemical Industry.

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The contributions of miR-25-3p, oxidative stress, and heat shock protein in a complex mechanism of autophagy caused by pollutant cadmium in common carp (Cyprinus carpio L.) hepatopancreas

Cited by 58 publications

References 59 publications

Effects of Probiotics on the Growth Performance, Antioxidant Functions, Immune Responses, and Caecal Microbiota of Broilers Challenged by Lipopolysaccharide

Effects of Probiotics on the Growth Performance, Antioxidant Functions, Immune Responses, and Caecal Microbiota of Broilers Challenged by Lipopolysaccharide

Salvia miltiorrhiza polysaccharides alleviates florfenicol-induced liver metabolic disorder in chicks by regulating drug and amino acid metabolic signaling pathways

Rehmannia glutinosa polysaccharides attenuates colitis via reshaping gut microbiota and short‐chain fatty acid production

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