Salvia miltiorrhiza polysaccharides alleviates florfenicol-induced liver metabolic disorder in chicks by regulating drug and amino acid metabolic signaling pathways

Liu, Wei; Liu, Ying; Fang, Siyuan; Yao, Weirong; Wang, Xiao; Bao, Yongzhan; Shi, Wei

doi:10.1016/j.psj.2022.101989

Cited by 6 publications

(5 citation statements)

References 47 publications

(47 reference statements)

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“…Flufenicol (FFC) is often used to prevent and reduce mortality in chickens. However, studies have found that FFC could promote oxidative stress and accelerate hepatocyte apoptosis, thus affecting the liver function of chickens (Han et al, 2020;Liu et al, 2022). In a model of liver injury caused by FFC in broilers, SMP alleviates oxidative stress and inflammatory injury in the liver, improves liver function and plays a liver protective role, which provides theoretical support for the study of SMP on the treatment of drug-induced liver injury (Geng et al, 2022).…”

Section: Hepatoprotective Effectmentioning

confidence: 90%

Recent developments in Salvia miltiorrhiza polysaccharides: Isolation, purification, structural characteristics and biological activities

Luo

Xue²,

Zheng³

et al. 2023

Front. Pharmacol.

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In recent years, natural polysaccharides have attracted more and more attention and research because of their value in the medicine, beauty and food fields. Salvia miltiorrhiza is a traditional Chinese herb that has been used for thousands of years and has antidiabetic, antifibrotic, neuroprotective, antioxidation, anti-inflammatory and other effects. It mainly includes rosmarinic acid, tanshinone I, tanshinone IIA, tanshinone IIB, procatechualdehyde, polysaccharide and salvianolic acids. Salvia miltiorrhiza polysaccharide is a polysaccharide extracted and isolated from Salvia miltiorrhiza and has diverse biological functions, including antioxidation, anti-tumor, hepatoprotective, anti-inflammatory, immune regulatory and cardioprotective effect. In this review, the extraction, purification, structural characterization and biological activity of SMPs are summarized and new perspectives for the future work of SMPs were also proposed, we hope our research can provide a reference for further research on SMPs.

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Section: Hepatoprotective Effectmentioning

confidence: 90%

Recent developments in Salvia miltiorrhiza polysaccharides: Isolation, purification, structural characteristics and biological activities

Luo

Xue²,

Zheng³

et al. 2023

Front. Pharmacol.

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show abstract

“…Studies also have shown that plant polysaccharides could regulate metabolic disorders in the body ( Li et al, 2021 ). Liu et al found that in a model of florfenicol ( FFC )-induced hepatic metabolic disorder in chicks, feeding Salvia miltiorrhiza polysaccharide alleviated the situation through drug metabolism and P450 signaling pathways ( Liu et al, 2022 ). 3-Hydroxybutyric acid, an organic acid ketone body and endogenous product of fatty acid oxidation is the core metabolite of antiaging, which can inhibit oxidative stress by changing the genes encoding FOXO3A and MT2 ( Møller, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota and serum metabolome reveal the mechanism by which TCM polysaccharides alleviate salpingitis in laying hens challenged by bacteria

Liu,

Yan,

et al. 2024

Poultry Science

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“…Moreover, a significant increase in the plasma glucose level in the Ab group suggested that antibiotics may cause metabolic disorders in broilers. Previous studies showed that antibiotic treatment can cause disorders of multiple metabolic pathways in chickens [ 19 ]. The small intestine is the main part of material digestion and nutrient absorption.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effects of Feeding Compound Probiotics and Antibiotics on Growth Performance, Gut Microbiota, and Small Intestine Morphology in Yellow-Feather Broilers

Feng,

Wu,

et al. 2023

Microorganisms

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This study was devoted to the comparison of the probiotic effect of compound probiotics to antibiotics as a feed additive for chicken. Two hundred and seventy newly hatched yellow-feather broilers were randomly divided into three groups: the control group (Con), probiotics (Pb), and antibiotics group (Ab). The Pb group received compound probiotics (Bifidobacterium, Lactobacillus acidophilus, Streptococcus faecalis, and yeast) via drinking water for 24 days. The Ab group received antibiotics (zinc bacitracin and colistin sulfate) in their diet for 24 days. All broilers were slaughtered on day 42. Compared with the Con group, the body weight was significantly increased on days 13, 28, and 42 in the Pb group (p < 0.05), and markedly increased on day 28 in the Ab group (p < 0.05). Compared with the Ab group, the body weight of the broilers in the Pb group increased significantly on day 13 (p < 0.05). Compared to the Con and Pb groups, the antibiotics treatment reduced the feed intake (p < 0.05), but there was no significant difference in the feed conversion ratio between the Ab and Pb groups (p > 0.05). The feed conversion ratio of the broilers treated with antibiotics or probiotics significantly decreased compared to the Con group (p < 0.05). The depth of duodenum, jejunum, and ileum crypts in the Pb group decreased significantly compared to the Con and Ab group (p < 0.05). The ratio of the villi length to crypt depth of duodenum, jejunum, and ileum epithelium was significantly increased in the Pb group compared to the Con group (p < 0.05). The genera Bacteroides and Barnesiella were the most significantly enriched bacteria in the Ab and Pb groups, respectively (p < 0.05). The expression of the genes related to antibiotic resistance was significantly decreased in the Pb group compared to the Ab group (p < 0.05). Although both compound probiotics and antibiotics can improve growth performance, antibiotics increased the abundance of harmful bacteria and drug-resistant genes, while probiotics increased Barnesiella abundance, which is related to a decrease in the drug-resistant gene expression. Moreover, the probiotics treatment improved small intestinal morphology and fecal emissions, while antibiotics have no significant effect on these indicators, indicating a bright future for probiotics as an alternative to feed antibiotics in the yellow-feather broiler industry.

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Salvia miltiorrhiza polysaccharides alleviates florfenicol-induced liver metabolic disorder in chicks by regulating drug and amino acid metabolic signaling pathways

Cited by 6 publications

References 47 publications

Recent developments in Salvia miltiorrhiza polysaccharides: Isolation, purification, structural characteristics and biological activities

Recent developments in Salvia miltiorrhiza polysaccharides: Isolation, purification, structural characteristics and biological activities

Gut microbiota and serum metabolome reveal the mechanism by which TCM polysaccharides alleviate salpingitis in laying hens challenged by bacteria

Comparison of the Effects of Feeding Compound Probiotics and Antibiotics on Growth Performance, Gut Microbiota, and Small Intestine Morphology in Yellow-Feather Broilers

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