The Contribution of Inflammation to Autism Spectrum Disorders: Recent Clinical Evidence

Prata, Joana; Machado, Ana Sofia; Doellinger, Orlando von; Almeida, Maria Inês; Barbosa, Mário A.; Coelho, Rui; Santos, Susana G.

doi:10.1007/978-1-4939-9554-7_29

Cited by 30 publications

(19 citation statements)

References 100 publications

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“…Figure S2 shows that axon guidance signaling and CXCR4 signaling are canonical pathways involved in the top network of genes involved in neuritogenesis. The intermediate subgroup is notably enriched in DAGs associated with the activation of neuroglia and astrocytes, suggesting inflammatory processes known to be involved in ASD [ 26 , 27 ]. Figure S3 shows that the neuroinflammation signaling pathway as well as the glucocorticoid signaling pathway are implicated by the genes involved in the abnormal morphology of neurons in the intermediate subgroup.…”

Section: Resultsmentioning

confidence: 99%

Phenotypic Subtyping and Re-Analysis of Existing Methylation Data from Autistic Probands in Simplex Families Reveal ASD Subtype-Associated Differentially Methylated Genes and Biological Functions

Lee

2020

IJMS

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Autism spectrum disorder (ASD) describes a group of neurodevelopmental disorders with core deficits in social communication and manifestation of restricted, repetitive, and stereotyped behaviors. Despite the core symptomatology, ASD is extremely heterogeneous with respect to the severity of symptoms and behaviors. This heterogeneity presents an inherent challenge to all large-scale genome-wide omics analyses. In the present study, we address this heterogeneity by stratifying ASD probands from simplex families according to the severity of behavioral scores on the Autism Diagnostic Interview-Revised diagnostic instrument, followed by re-analysis of existing DNA methylation data from individuals in three ASD subphenotypes in comparison to that of their respective unaffected siblings. We demonstrate that subphenotyping of cases enables the identification of over 1.6 times the number of statistically significant differentially methylated regions (DMR) and DMR-associated genes (DAGs) between cases and controls, compared to that identified when all cases are combined. Our analyses also reveal ASD-related neurological functions and comorbidities that are enriched among DAGs in each phenotypic subgroup but not in the combined case group. Moreover, relational gene networks constructed with the DAGs reveal signaling pathways associated with specific functions and comorbidities. In addition, a network comprised of DAGs shared among all ASD subgroups and the combined case group is enriched in genes involved in inflammatory responses, suggesting that neuroinflammation may be a common theme underlying core features of ASD. These findings demonstrate the value of phenotype definition in methylomic analyses of ASD and may aid in the development of subtype-directed diagnostics and therapeutics.

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Section: Resultsmentioning

confidence: 99%

Phenotypic Subtyping and Re-Analysis of Existing Methylation Data from Autistic Probands in Simplex Families Reveal ASD Subtype-Associated Differentially Methylated Genes and Biological Functions

Lee

2020

IJMS

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“…350 Experimental and clinical studies have revealed changes in the structure of the human gut microbiome as a result of degenerative diseases, 281 depression, 351,352 and autism, 41,353 which are accompanied by inflammatory processes. [354][355][356] Currently, several studies are aimed at identifying differences in the microbiome of patients with Parkinson's disease compared to healthy control people. 350 While most of them used fecal samples as a proxy for microbiome composition in the distal colon, some examined mucosal opportunistic pathogens or even saliva and nasal mucosa samples.…”

Section: Microbiome Disruption In Parkinson's Disease and Covid-19 Altered Microbiome Composition In Parkinson's Diseasementioning

confidence: 99%

Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention

Даниленко¹,

Devyatkin²,

Марсова³

et al. 2021

JIR

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In the last decade, metagenomic studies have shown the key role of the gut microbiome in maintaining immune and neuroendocrine systems. Malfunction of the gut microbiome can induce inflammatory processes, oxidative stress, and cytokine storm. Dysfunction of the gut microbiome can be caused by short-term (virus infection and other infectious diseases) or long-term (environment, nutrition, and stress) factors. Here, we reviewed the inflammation and oxidative stress in neurodegenerative diseases and coronavirus infection (COVID-19). Here, we reviewed the renin-angiotensin-aldosterone system (RAAS) involved in the processes of formation of oxidative stress and inflammation in viral and neurodegenerative diseases. Moreover, the coronavirus uses ACE2 receptors of the RAAS to penetrate human cells. The coronavirus infection can be the trigger for neurodegenerative diseases by dysfunction of the RAAS. Pharmabiotics, postbiotics, and nextgeneration probiotics, are considered as a means to prevent oxidative stress, inflammatory processes, neurodegenerative and viral diseases through gut microbiome regulation.

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“…Autism spectrum disorder (ASD) is characterized by persistent alterations in social interactions across multiple contexts, communication deficits, and restricted repetitive behaviors, interests, or activities 1 . This neurodevelopmental condition is four times more frequent in boys than girls, 2 and its susceptibility is attributed to heterogeneous genetic influences and a combination of environmental, autoimmune, metabolic, and inflammatory factors 3‐6 . Social communication impairment in ASD is linked to the desynchronization of physiological and behavioral responses to environmental cues 7,8 …”

Section: Introductionmentioning

confidence: 99%

Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances

Cruz‐Machado

Campos

Fadini

et al. 2021

Journal of Pineal Research

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Autism spectrum disorder (ASD) is characterized by persistent alterations in social interactions across multiple contexts, communication deficits, and restricted repetitive behaviors, interests, or activities. 1 This neurodevelopmental condition is four times more frequent in boys than girls, 2 and its susceptibility is attributed to heterogeneous genetic influences and a combination of environmental, autoimmune, metabolic, and inflammatory factors. 3-6 Social communication impairment in ASD is linked to the desynchronization of physiological and behavioral responses to environmental cues. 7,8 The night-time release of pineal melatonin significantly modulates cells of the peripheral circulation and the cerebrospinal fluid, thereby synchronizing central and peripheral clocks, including the circadian rhythm of the endocrine and

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The Contribution of Inflammation to Autism Spectrum Disorders: Recent Clinical Evidence

Cited by 30 publications

References 100 publications

Phenotypic Subtyping and Re-Analysis of Existing Methylation Data from Autistic Probands in Simplex Families Reveal ASD Subtype-Associated Differentially Methylated Genes and Biological Functions

Phenotypic Subtyping and Re-Analysis of Existing Methylation Data from Autistic Probands in Simplex Families Reveal ASD Subtype-Associated Differentially Methylated Genes and Biological Functions

Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention

Disrupted nocturnal melatonin in autism: Association with tumor necrosis factor and sleep disturbances

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