The contribution of humoral immunity to the control of avian reoviral infection in chickens after vaccination with live reovirus vaccine (strain 2177) at an early age

Loon, A.A.W.M. van; Kosman, Willeke; Zuilekom, Hanneke I. van; Riet, Suzanne van; Frenken, M.; Schijns, Virgil E.J.C.

doi:10.1080/0307945021000070679

Cited by 11 publications

(4 citation statements)

References 16 publications

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“…Even though licensed vaccines against ARV are available for chickens in Europe, the emergence of new variant ARV strains limits their efficacy in the field (78). Commercial vaccines for turkeys are not available, but the use of autogenous vaccines in turkey breeders is common and highly successful in preventing viral arthritis (73). In contrast to heterologous protection, homologous protection is adequate (79), which underlines the need to choose a representative strain from an affected flock to provide sufficient protection by vaccination and to adapt the autogenous vaccine based on detailed follow-up investigations on circulating strains (73,78).…”

Section: Avian Reovirusmentioning

confidence: 99%

“…Newly hatched birds are very susceptible to infection with avian reoviruses (ARV), thus vaccination of breeders is a common strategy to provide protection of the offspring via maternal antibodies (73). However, ARV infection may also be controlled in the offspring without detectable antibody titers, suggesting an additional level of protection provided by cellular immunity (74). This possibility is further supported by the short half-life of maternal antibodies in the offspring (4.7 days post hatch) (75).…”

Section: Avian Reovirusmentioning

confidence: 99%

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Veterinary Autogenous Vaccines for Poultry in Europe—Many Ways to Crack an Egg

Sulejmanovic,

Schnug,

Philipp

2023

Avian Diseases

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Section: Avian Reovirusmentioning

confidence: 99%

Section: Avian Reovirusmentioning

confidence: 99%

Veterinary Autogenous Vaccines for Poultry in Europe—Many Ways to Crack an Egg

Sulejmanovic,

Schnug,

Philipp

2023

Avian Diseases

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“…Depending on the vaccine type and the pathogen, CMI may be more significant for protection of the birds than humoral immunity (80,138). Van Loon et al (139) demonstrated that even in the absence of B lymphocytes, vaccines may protect chickens against reovirus challenge, suggesting an antibody-independent mechanism. Despite the fact that some pathogens may be well controlled by neutralizing antibodies against surface proteins, which interfere with virus receptor binding and entry, lack of cross-protection may be observed frequently after vaccination.…”

Section: Acquired Immune Responsesmentioning

confidence: 99%

The Immunological Basis for Vaccination

Rautenschlein,

Schat

2023

Avian Diseases

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Vaccination is crucial for health protection of poultry and therefore important to maintaining high production standards. Proper vaccination requires knowledge of the key players of the well-orchestrated immune system of birds, their interdependence and delicate regulation, and, subsequently, possible modes of stimulation through vaccine antigens and adjuvants. The knowledge about the innate and acquired immune systems of birds has increased significantly during the recent years but open questions remain and have to be elucidated further. Despite similarities between avian and mammalian species in their composition of immune cells and modes of activation, important differences exist, including differences in the innate, but also humoral and cell-mediated immunity with respect to, for example, signaling transduction pathways, antigen presentation, and cell repertoires. For a successful vaccination strategy in birds it always has to be considered that genotype and age of the birds at the time point of immunization as well as their microbiota composition may have an impact and may drive the immune reactions into different directions. Recent achievements in the understanding of the concept of trained immunity will contribute to the advancement of current vaccine types helping to improve protection beyond the specificity of an antigen-driven immune response. The fast developments in new omics technologies will provide insights into protective B-and T-cell epitopes involved in cross-protection, which subsequently will lead to the improvement of vaccine efficacy in poultry.RESUMEN. Estudio recapitulativo-Bases inmunológicas de la vacunación. La vacunación es crucial para la protección de la salud de las aves comerciales y por lo tanto, importante para mantener altos estándares de producción. Una vacunación adecuada requiere el conocimiento de los factores clave del sistema inmunológico bien orquestado de las aves, su interdependencia y su delicada regulación y posteriormente, los posibles modos de estimulación a través de antı genos y adyuvantes de las vacunas. El conocimiento sobre los sistemas inmunológicos innato y adquirido de las aves ha aumentado significativamente durante los últimos años, pero quedan preguntas abiertas que deben dilucidarse con profundidad. A pesar de las similitudes entre las especies de aves y mamı feros en la composición de células inmunes y modos de activación, existen diferencias importantes, incluidas las diferencias en la inmunidad innata, pero también en la inmunidad humoral y en la mediada por células, con respecto a las vı as de transducción de señales, la presentación de antı genos. y repertorios celulares. Para una estrategia de vacunación exitosa en las aves, siempre se debe considerar que el genotipo y la edad de las aves en el momento de la inmunización, ası como la composición de su microbiota pueden tener un impacto y pueden impulsar las reacciones inmunes en diferentes direcciones. Los logros recientes en la comprensión del concepto de inmunidad entrenada contribuirán al avance...

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“…Uma vez que as aves em geral apresentam resistência natural à infecção com poucas semanas de idade, as vacinas e programas de vacinação são direcionados para proverem a proteção aos pintos nos primeiros dias de vida (JONES, 2000;JONES;GEORGIOU, 1984a). Os esquemas de vacinação para ARV são normalmente realizados em pintos de um dia de idade ou em reprodutoras, as quais transferem os anticorpos aos pintos por via vertical (VAN DER HEIDE; KALBAC; HALL, 1976; VAN LOON et al, 2003).…”

Section: Prevenção E Controleunclassified

Reovirose aviária: um panorama

Assunção

Palka

Pavoni

2018

Rev. Educ. Cont. Med. Vet. Zootec.

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A avicultura é um setor de grande importância na economia brasileira tanto pelo aumento do consumo interno quanto pelo crescimento na exportação de carne de frango. A modernização da atividade avícola permitiu a criação adensada de animais, facilitando, no entanto, a rápida disseminação de patógenos que reduzem os índices de produtividade dos plantéis. Nesta revisão, é destacado o reovírus aviário, importante agente de artrite em aves que apresenta distribuição mundial. As aves acometidas apresentam redução no ganho de peso devido à dificuldade de locomoção. Além da artrite, o vírus pode estar relacionado a uma variedade de condições patológicas, como distúrbios entéricos e respiratórios, hepatite e miocardite. A principal forma de prevenção e controle é a vacinação do plantel. No entanto, devido à grande variabilidade genética do reovírus aviário, a vacina utilizada pode não ser eficiente contra estirpes que circulam no campo. O artigo traz uma visão geral sobre a biologia do vírus, sua variabilidade e propostas de classificação dos isolados, patologia da doença e diagnóstico da infecção.

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The contribution of humoral immunity to the control of avian reoviral infection in chickens after vaccination with live reovirus vaccine (strain 2177) at an early age

Abstract: (2003) The contribution of humoral immunity to the control of avian reoviral infection in chickens after vaccination with live reovirus vaccine (strain 2177) at an early age, Avian Pathology, 32:1, 15-23,

Cited by 11 publications

References 16 publications

Veterinary Autogenous Vaccines for Poultry in Europe—Many Ways to Crack an Egg

Veterinary Autogenous Vaccines for Poultry in Europe—Many Ways to Crack an Egg

The Immunological Basis for Vaccination

Reovirose aviária: um panorama

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