The Contribution of Diabetes Education in the Treatment of People with Type 2 Diabetes and Risk of Cardiovascular Disease

Cavicchioli, Maria Gabriela Secco; Guerbali, C. C. L.; Ochiai, Chikayuki; Silva, Rufino; Câmara, Gabriel Barbosa; Petry, Tarissa Beatrice Zanata

doi:10.1007/s11883-016-0591-4

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…12 Thus adherence, as a cornerstone in the management of the disease, needs to be studied and promoted in the setting of the social, demographic and clinical differences of each population.…”

Section: Introductionmentioning

confidence: 99%

Factors related to self-care activities of patients with type 2 diabetes mellitus

et al. 2018

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Objective: To verify self-care activities of patients with type 2 diabetes mellitus and to analyze the relationship with sociodemographic and clinical variables. Method: A cross-sectional study was performed of 149 people using the Diabetes Self-Care Activities Questionnaire. Results: Of the 15 self-care activities analyzed, appropriate behavior was observed for aspects related to medication use and inadequate for fruit/vegetable consumption, blood sugar testing and physical exercise. The correct use of medications was correlated to marital status. Regarding inadequate behaviors, there were associations of fruit/vegetable consumption with skin color and place of residence and blood sugar testing with marital status and inverse correlations of physical exercise with systolic blood pressure, pulse pressure, waist circumference and postprandial glycemia. Conclusion: The results of this research contribute by strengthening the line of care in chronic diseases and assist in divulging the importance of supported self-care. Implications for practice: The findings of this research provided information relevant to the planning of care.

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Section: Introductionmentioning

confidence: 99%

Factors related to self-care activities of patients with type 2 diabetes mellitus

et al. 2018

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“…It is well established that DM is closely associated with adverse health outcomes, among which micro- and macrovascular complications are considered the most severe manifestations ( 23 , 24 ). Intensive treatment regimens that normalize glucose levels were previously considered effective therapeutic approaches; however, the risk of cardiovascular events is not efficiently controlled.…”

Section: Discussionmentioning

confidence: 99%

KDM3A inhibition attenuates high concentration insulin‑induced vascular smooth muscle cell injury by suppressing MAPK/NF‑κB pathways

et al. 2017

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Previous studies have indicated that lysine (K)-specific demethylase 3A (KDM3A) is associated with diverse diabetes-associated cardiovascular complications in response to high glucose levels. However, the effects of KDM3A on the pathological progression of cardiovascular injuries in response to high insulin levels remain unknown. The present study aimed to explore whether KDM3A knockdown may attenuate high insulin-induced vascular smooth muscle cell (VSMC) dysfunction, and to further investigate the underlying mechanisms. Primary VSMCs were isolated from the thoracic aorta of Sprague-Dawley rats. Lentiviral vectors encoding control-small interfering (si)RNA or KDM3A-siRNA were transduced into VSMCs for 72 h, and cells were subsequently incubated in medium containing 100 nM insulin for a further 5 days. Cellular proli feration, migration and apoptosis were measured by Cell Counting kit-8, Transwell chamber assay and flow cytometry, respectively. Reactive oxygen species (ROS) were detected using the dihydroethidium fluorescent probe. The mRNA expression levels of interleukin-6 and monocyte chemotactic protein-1 were measured by reverse transcription-quantitative polymerase chain reaction. Furthermore, the protein expression levels of KDM3A, mitogen-activated protein kinases (MAPKs), nuclear factor (NF)-κB/p65, B-cell lymphoma 2 (Bcl-2)-associated X protein and Bcl-2 were evaluated by western blotting. Lentivirus transduction with KDM3A-siRNA markedly reduced the elevated expression of KDM3A induced by high insulin stimulation in VSMCs. In addition, inhibition of KDM3A significantly ameliorated insulin-induced VSMC proliferation and migration, which was accompanied by decreased ROS levels, cell apoptosis and inflammatory cytokine levels. Furthermore, KDM3A gene silencing mitigated phosphorylation of MAPKs and NF-κB/p65 activation. In conclusion, KDM3A inhibition may exert numerous protective effects on high insulin-stimulated VSMCs, and the underlying mechanisms may be partly associated with inactivation of MAPK/NF-κB signaling pathways.

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“…(2017) [23]. В отличие от общего уровня образования, обучение в конкрет-ной ситуации (заболевание, долговременная тера-пия) повышают приверженность к лечению [24,25].…”

Section: врач -лечит а больной -лечится? современные представления оunclassified

Clinician — Treats, and Patient — Being Treated? Recent View on the Treatment Adherence in Coronary Heart Disease Setting

Шайдюк¹,

Кудинова²,

Таратухин³

et al. 2017

Russ J Cardiol

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Медицинская наука создала широкий спектр инструментов для предотвращения и лечения заболе-ваний. Многие из таких инструментов требуют актив-ного участия самого пациента, что предполагает регу-лярное следование рекомендациям, регулярный приём препаратов. Это получило название привер-женности к лечению. В англоязычной литературе ему соответствует два термина: compliance и adherence. Они имеют разное значение: compliance предполагает строгое следование предписаниям -"делать как ска-зано", тогда как adherence подразумевает реализацию предписания с учётом внешних (социальные условия, среда) и внутренних (характер, психологические состояния, убеждения) факторов. В отличие от "ком-плаентного" индивида, "адгерентный" может добав-лять элемент "творчества" к рекомендациям. Он может модифицировать предписания, следовать больше чем назначено или меньше. О комплайнсе, следовательно, нужно говорить в отношении приёма препаратов, тогда как немедикаментозное лечение предпочтительно определять через "адгерентность" [1]. Выделено также понятие "конкордантность" (concordance). Она определяется как согласованная между пациентом и врачом позиция относительно режима лечения, результатов и соответствующего поведения; отношения в большей степени совмест-ные, чем определяемые комплайнсом [2]. Pardaens S, et al. (2017) изучали причины выхода пациентов из программ кардиореабилитации после ОКС, кардиохирургического вмешательства и при сердечной недостаточности. В исследование вошло 489 пациентов. Факторами, связанными с прежде-временным выходом из программы реабилитации (то есть, пропуск более половины занятий; таковых было 20%, n=96), оказались анамнез инсульта (отношение шансов, ОШ =4,18), наличие хронической обструк- Обзор литературы включает данные современных исследований привержен-ности к терапии и немедикаментозному лечению преимущественно у больных ишемической болезнью сердца. Рассматриваются различные способы повы-шения приверженности, приводятся психологические модели "информация-мотивация-стратегия", "транстеоретическая модель". Рассматривается феномен "политаблетки". Приводятся различия между тремя вариантами приверженности к лечению (compliance, adherence, concordance) в зависимо-сти от активности участия самого пациента. The literary review includes data from recent research on the medication and nonmedication treatment adherence of coronary heart disease patients. The various approaches considered, of the adherence improvement, and psychological models presented, the "information-motivation-strategy" and "transtheoretical model". The polypill phenomenon is considered. Also three terms on adherence are commented: compliance, concordance and adherence itself, depending on the part of patient's active role. ВРАЧ -ЛЕЧИТ, А БОЛЬНОЙ -ЛЕЧИТСЯ? СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О ПРИВЕРЖЕННОСТИ К ТЕРАПИИ ПАЦИЕНТОВ С ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦА Российский кардиологический журнал Russ

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The Contribution of Diabetes Education in the Treatment of People with Type 2 Diabetes and Risk of Cardiovascular Disease

Cited by 5 publications

References 33 publications

Factors related to self-care activities of patients with type 2 diabetes mellitus

Factors related to self-care activities of patients with type 2 diabetes mellitus

KDM3A inhibition attenuates high concentration insulin‑induced vascular smooth muscle cell injury by suppressing MAPK/NF‑κB pathways

Clinician — Treats, and Patient — Being Treated? Recent View on the Treatment Adherence in Coronary Heart Disease Setting

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