The contribution of 18F-FDG PET in preoperative epilepsy surgery evaluation for patients with temporal lobe epilepsy

Willmann, Olaf; Wennberg, Richard; May, Theodor W.; Woermann, Friedrich G.; Pohlmann‐Eden, Bernd

doi:10.1016/j.seizure.2007.04.001

Cited by 196 publications

(120 citation statements)

References 58 publications

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“…Although the overall sensitivity of PET varied considerably across the studies, PET displayed moderate to high sensitivity in localizing the seizure focus among temporal lobe epilepsy patients (range, 71-89%). Again, this is in line with the previous meta-analysis which showed 86% of patients with good outcome had an ipsilateral PET finding (49). For MRI and EEG, the reported sensitivity (MRI 41-83%; EEG 36-81%) also varied greatly across the studies.…”

supporting

confidence: 88%

“…A previous meta-analysis reported a concordance value of 67% between PET and invasive EEG recording. 49 This analysis included only patients with temporal lobe epilepsy and excluded pediatric patients. Still, data from this systematic review are consistent with their findings and showed a 56 to 90% agreement between PET hypometabolism and seizure onset localized by intracranial EEG among adults.…”

mentioning

confidence: 99%

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The Utility of Positron Emission Tomography in Epilepsy

Burneo

Poon

Kellett

et al. 2015

Can. J. Neurol. Sci.

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The role of fludeoxyglucose F 18 positron emission tomography (PET) in the presurgical evaluation of patients with medically intractable epilepsy continues to be refined. The purpose of this study was to systematically review the literature to assess the diagnostic accuracy and utility of PET in this setting. Thirty-nine studies were identified through MEDLINE and EMBASE databases that met the inclusion criteria. In adult patients, PET hypometabolism showed a 56 to 90% agreement with seizure onset localized by intracranial electroencephalogram (pediatric: 21 to 86%). In temporal lobe epilepsy patients with good surgical outcome, PET displayed moderate to high sensitivity in localizing the seizure focus (range: 71 to 89%). The sensitivity increased by 8 to 23% when PET results were combined with magnetic resonance imaging or electroencephalogram. PET has been shown to affect patient management by improving the guidance of intracranial electrodes placement, altering the decision to perform surgery, or excluding patients from further evaluation.RÉSUMÉ: Utilité de la tomographie par émission de positons dans l'épilepsie. Le rôle de la tomographie par émission de positons (PET scan) au 18F fluodésoxyglucose (18F-FDG) dans l'évaluation préchirurgicale de patients présentant une épilepsie réfractaire au traitement médical est constamment raffiné. Le but de cette étude était de revoir systématiquement la littérature afin d'évaluer la précision du diagnostic et l'utilité du PET scan dans ce contexte. Nous avons identifié 39 études dans les bases de données MEDLINE et EMBASE qui rencontraient nos critères d'inclusion. Chez les patients adultes, un hypométabolisme au PET scan concordait entre 56 et 90% avec le début de la crise localisé par l'électroencéphalographie intracrânienne (patients pédiatriques: entre 21 et 86%). Chez les patients atteints d'épilepsie temporale chez qui le résultat chirurgical avait été favorable, le PET scan avait une sensibilité de modérée à élevée pour localiser le foyer épileptogène (écart : 71 à 89%). La sensibilité augmentait de 8 à 23% quand les résultats du PET scan étaient combinés à l'imagerie par résonance magnétique ou à l'électroencéphalographie. Il est démontré que le PET scan influence le traitement du patient en améliorant le guidage lors de la mise en place des électrodes intracrâniennes, en modifiant la décision de procéder à une chirurgie ou en évitant de procéder à des examens plus poussés chez certains patients.

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supporting

confidence: 88%

mentioning

confidence: 99%

The Utility of Positron Emission Tomography in Epilepsy

Burneo

Poon

Kellett

et al. 2015

Can. J. Neurol. Sci.

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“…La décharge ictale, sa voie de propagation ainsi que les remaniements structurels et la durée de l'épilepsie jouent un rôle dans ces résultats (25,26 (27). Les SPECT peuvent également être réalisées en phase interictale, mettant en évidence des hypoperfusions au niveau du ou des foyers épileptogènes.…”

Section: Sermentunclassified

Consequences of mTOR inhibition on epileptogenesis and neuroprotection in lithium-pilocarpine model of epilepsy in rats

Cullier

Maskali

Clement

et al. 2017

European Journal of Paediatric Neurology

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“…The sensitivity of this procedure for detecting hypometabolism of the temporal lobe in the interictal state is high, ranging from 80 to 90% [2,3,7,9]. This method provides reliable information for lateralizing the epileptogenic temporal lobe in "MRI-negative" cases, with a yield ranging from 45 to almost 90 percent [2][3][4][5][6][7]. The sensitivity improves when seizures are frequent or when imaging is performed immediately after seizure onset [24].…”

Section: Imz-spect For Childhood Epilepsymentioning

confidence: 99%

“…However, some children with intractable focal epilepsy do not show any abnormal findings on brain MRI, and it is not always straightforward to identify the epileptic focus precisely based on clinical and EEG findings alone. In such cases, brain functional neuroimaging studies may be useful [2][3][4][5][6][7]. Many studies have reported the usefulness of interictal/ictal cerebral blood flow single photon emission computed tomography (SPECT) [8][9][10][11][12] and interictal 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) [2,3,7,10,13].…”

Section: Introductionmentioning

confidence: 99%

Usefulness of 123I-iomazenil SPECT for childhood focal epilepsies

Okamoto

Oguni

Hirano

et al. 2011

E&S

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Purpose:We investigated the usefulness of 123 I-iomazenil (IMZ-) SPECT to detect epileptic foci in children with symptomatic focal epilepsy (SFE). Subjects: 21 children with SFE who underwent IMZ-SPECT to identify the epileptic focus were studied. Methods: We retrospectively compared the localization and lateralization of epileptic foci obtained from visualization of IMZ-SPECT images and those speculated based on a combination of clinical manifestations, EEG findings, and brain MRI. We then verified the concordance of the results between the two methods. Results: There was concordance in both lateralization and localization in 9/12 patients with temporal lobe epilepsy (75%), in 2/5 patients Correspondence to: Hirokazu Oguni, MD, Department of Pediatrics, Tokyo Women's Medical University, 8-1 Kawada-cho, Tokyo 162, hoguni@ped.twmu.ac.jp Epilepsy & Seizure Journal of Japan Epilepsy Society Vol.4 No.1 (2011)

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The contribution of 18F-FDG PET in preoperative epilepsy surgery evaluation for patients with temporal lobe epilepsy

Cited by 196 publications

References 58 publications

The Utility of Positron Emission Tomography in Epilepsy

The Utility of Positron Emission Tomography in Epilepsy

Consequences of mTOR inhibition on epileptogenesis and neuroprotection in lithium-pilocarpine model of epilepsy in rats

Usefulness of 123I-iomazenil SPECT for childhood focal epilepsies

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