Usefulness of 123I-iomazenil SPECT for childhood focal epilepsies

Abstract

Purpose:We investigated the usefulness of 123 I-iomazenil (IMZ-) SPECT to detect epileptic foci in children with symptomatic focal epilepsy (SFE). Subjects: 21 children with SFE who underwent IMZ-SPECT to identify the epileptic focus were studied. Methods: We retrospectively compared the localization and lateralization of epileptic foci obtained from visualization of IMZ-SPECT images and those speculated based on a combination of clinical manifestations, EEG findings, and brain MRI. We then verified the concordance of the results between the two methods. Results: There was concordance in both lateralization and localization in 9/12 patients with temporal lobe epilepsy (75%), in 2/5 patients Correspondence to: Hirokazu Oguni, MD, Department of Pediatrics, Tokyo Women's Medical University, 8-1 Kawada-cho, Tokyo 162, hoguni@ped.twmu.ac.jp Epilepsy & Seizure Journal of Japan Epilepsy Society Vol.4 No.1 (2011)