The Contents of Phenol and Flavonoid Compounds in Water Extract of Gyrinops Versteegii Leaves Have Potentially as Natural Antioxidants and Hypoglicemic in Hyperglycemic Wistar Rats

Abstract

Phenols and flavonoids compounds in their activities as antioxidants can reduce blood glucose levels (hypoglycemic) through a mechanism to inhibit cell damage at pancreatic Langerhans gland, inhibit glucose absorption in the intestine and cell resistance to insulin. Preliminary analysis shows that total phenol and flavonoid contens is 2099,5025 mg GAE / 100 g, and 8133,322 mg QE / 100 gram, Antioxidant capacity with IC50 = 12.58 mg / mL. LD50 = 6,355,3536 gram. This results revealad that the water extract of Gyrinops versteegii leaves can be developed as an alternative to natural antioxidant, safe for consumption and can reduce blood glucose in hyperglycemic Wistar rats. The results of the measurement of the effect of decreasing blood glucose content showed that the water extract of Gyrinops versteegii leaves at doses of 100, 200 and 400 mg / kgBW significantly (p <0.01) could reduce blood glucose contents in hyperglycemic Wistar rats. The activity of reducing blood glucose levels (hypoglycemic) with oral doses of water extract of Gyrinops versteegii leaves was 100,200 and 400 mg / kgBW was 53.6% (53.6 ± 5.8), 58.9% (58.9 ± 8.6 ) and 75.8% (75.8 ± 1.3). High contents of phenol and flavonoids allegedly a factor that causes water extract of Gyrinops versteegii leaves to reduce blood glucose levels in hyperglycemic Wistar rats.

Effect of palm sap (Arenga pinnata) on blood glucose levels of mice (Mus musculus) alloxan-induced diabetic

“…Flavonoids are antioxidants that can inhibit pancreatic cell damage by neutralizing free radicals (Parwata et al 2018). In addition, flavonoids stop the peroxidation process by inhibiting enzymes that produce superoxide anions and decreasing alkoxyl and peroxyl radicals (Yuslianti 2017).…”

“…In addition, flavonoids stop the peroxidation process by inhibiting enzymes that produce superoxide anions and decreasing alkoxyl and peroxyl radicals (Yuslianti 2017). Furthermore, flavonoids act directly on pancreatic -cells, activating the cAMP signal cascade to boost insulin production, triggered by glucose (Hikmah et al 2016), preventing glucose absorption in the gut (Parwata et al 2018).…”

Elucidating the Role of Prickly Pear Fruits (Opuntia littoralis) in Mitigation of Cadmium Toxicity in Oreochromis niloticus: Impacts on Haemato-Biochemical and Immunological Responses

“…Conversely, the lower blood glucose levels observed in the OLFE-forti ed groups under pre-cadmium and post-cadmium exposures in comparison to the OLFE-0% (control group) could potentially be attributed to O. littoralis's hypoglycemic effect, which is mediated by the presence of bioactive ingredients, speci cally phenols, avonoids, and saponins. Parwata et al (2018) revealed that avonoids and phenolic constituents can reduce concentrations of glucose in the blood because of their strong antidiabetic effects. Furthermore, among the many biological consequences of saponins, a type of phytochemical, is the reduction of glucose levels and inhibition of the enzymes that change disaccharides into simple carbohydrates (Oishi et al 2007).…”