The Consumption of a Structured Triacylglycerol Containing Behenic and Oleic Acids Increases Fecal Fat Excretion in Humans

Kojima, Makiko; Arishima, Toshiharu; Shimizu, Ryoma; Kohno, M.; Kida, Haruyasu; Hirotsuka, Motohiko; Ikeda, Ikuo

doi:10.5650/jos.62.997

Cited by 11 publications

(6 citation statements)

References 9 publications

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“…Fecal lipids were extracted using a 2:1 ( v/v ) chloroform: methanol mixture under acidic conditions (acetic acid was added to a final concentration of 4%) [22] and determined gravimetrically.…”

Section: Methodsmentioning

confidence: 99%

Effects of Paramylon Extracted from Euglena gracilis EOD-1 on Parameters Related to Metabolic Syndrome in Diet-Induced Obese Mice

et al. 2019

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Paramylon (PM), a type of β-glucan, functions like dietary fiber, which has been suggested to exert a protective effect against obesity. We evaluated the potential beneficial effects of PM powder on obesity in mice. Male C57BL/6J mice were fed a high-fat diet supplemented with either 2.5 or 5% PM powder, extracted from Euglena gracilis, for 74 days. Growth parameters, abdominal fat content, serum biochemical markers, hepatic lipid accumulation and hepatic mRNA expression were measured. Dietary supplementation with PM resulted in decreased food efficiency ratios and abdominal fat accumulation. Dose-dependent decreases were observed in postprandial glucose levels, serum low-density lipoprotein (LDL)-cholesterol, and serum secretary immunoglobulin A (sIgA) concentrations. PM supplementation increased peroxisome proliferator-activated receptor α (PPARα) mRNA expression in the liver which is suggested to induce β-oxidation through activation of acyl-coenzyme A oxidase (ACOX), carnitine palmitoyltransferase (CPT) and fatty acid transport protein 2 (FATP2) mRNA expression. Changes in fatty acid metabolism may improve lipid and glucose metabolism. In conclusion, a preventive effect against obesity was observed in mice given a PM-enriched diet. The mechanism is suggested to involve a reduction in both serum LDL-cholesterol levels and the accumulation of abdominal fat, in addition to an improvement in postprandial glucose concentration.

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Section: Methodsmentioning

confidence: 99%

Effects of Paramylon Extracted from Euglena gracilis EOD-1 on Parameters Related to Metabolic Syndrome in Diet-Induced Obese Mice

et al. 2019

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“…Total lipids in feces were extracted with a chloroform: methanol mixture (2:1. v/v) under the acidic condition (acetic acid was added to a final concentration of 4%). 20) Total lipids in the feces were determined gravimetrically.…”

Section: Analysis Of Total Lipids In Fecesmentioning

confidence: 99%

Effects of liquid konjac on parameters related to obesity in diet-induced obese mice

Aoe

Kudo

Sakurai³

2015

Bioscience, Biotechnology, and Biochemistry

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Konjac-mannan has been suggested to exert a protective effect against visceral obesity. However, there is little knowledge about the effects of liquid konjac (LK) that is partially alkali gelled. The purpose of the present work was to evaluate the potential beneficial effects of a LK powder on obesity in mice. Male C57BL/6J mice were fed a high-fat diet supplemented with either 2.5 or 5% LK powder for 80 days. Growth parameters, abdominal fat content, serum biochemical markers, and hepatic lipid accumulations were measured. Dietary supplementation with LK resulted in decreased body weight gain and abdominal fat accumulation. Dose-dependent decreases were observed in accumulation of hepatic lipids and serum total cholesterol, leptin, insulin concentrations. The study findings indicated that LK had preventing effect against obesity, including the reduction of abdominal and hepatic lipid accumulation and serum parameters related to obesity.

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“…a). The 13‐OH‐22:0 lipid tail of 22:0‐SL is of special interest because it is structurally related to two commercially important oleochemicals, i.e., behenic acid and erucic acid (Kojima et al, , ; Sonntag, ; Tynek and Ledóchowska, ). Despite the vast application potential of 22:0‐SL and its components, relatively few studies on P. bogoriensis and 22:0‐SL have been reported in the literature since the pioneering work from Light's laboratory (Breithaupt and Light, ; Cutler and Light, , ; Esders and Light, , b).…”

Section: Introductionmentioning

confidence: 99%

Low‐Temperature Crystallization for Separating Monoacetylated Long‐Chain Sophorolipids: Characterization of Their Surface‐Active and Antimicrobial Properties

Solaiman

Ashby

Núñez

et al. 2020

J Surfact & Detergents

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Pseudohyphozyma (formerly Rhodotorula) bogoriensis synthesizes long-chain-length (22-carbon chain) sophorolipids (22:0-SL) that are variously acetylated at the 6 0 -or/and 6 00 -carbons of the sophorose unit. In this paper, we describe a low-temperature crystallization protocol that preferentially separates the 6 0 -monoacetylated 22:0-SL (6 0 -Ac 1 -22:0-SL) from a parental mixture of 22:0-SL containing a majority (64.7%) of the 6 0 ,6 00diacetylated moiety (6 0 ,6 00 -Ac 2 -22:0-SL), as deduced from high-pressure-liquid-chromatography evaporative-lightscattering-detection (HPLC-ELSD) and LC/Q-TOF-MS analyses. Tensiometry measurements using the Wilhelmy plate method yielded minimum-surface-tension (SFT min ) andcritical-micelle-concentration (CMC) values of 34.6 AE 1.0 mN m −1 and 0.014 mM, respectively, for 6 0 -Ac 1 -22:0-SL (CRYSTAL) fraction and 34.9 AE 1.0 mM m −1 (SFT min ) and 0.018 (CMC) for the hexane precipitate (Hx-PRCP) fraction containing a high concentration (89.2%) of the diacetylated 6 0 ,6 00 -Ac 2 -22:0-SL after crystal removal. In contrast, the SFT min and CMC of the well-studied 16-18 carbon (C 16-18) -SL of Starmerella bombicola were 35-37.2 mN m −1 and 0.05-(>0.3) mM, respectively. Individually, the purified CRYSTAL and Hx-PRCP fractions exhibited a similar degree of strong growth-inhibition activity against Cutibacterium (formerly Propionibacterium) acnes as determined by an agar-plate zone of inhibition assay. Study on the growth inhibition of oral health-related bacteria, i.e., Streptococcus mutans and Lactobacillus acidophilus, showed that, depending on the bacteria and strains tested, the CRYSTAL fraction was either slightly better than or equally effective as the Hx-PRCP fraction in inhibiting cell growth. Fig. 1 Structures of sophorolipids. (a) 13-hydroxydocosanoic acid-sophorolipid (22:0-SL). (b) Lactonic 17-hydroxy-Δ9-octadecenoic acidsophorolipid (18:1-SL). R = -H or -Acetyl. The carbons at 6 0 -and 6 00 -position are indicated by arrows 554 J Surfact Deterg J Surfact Deterg (2020) 23: 553-563 555 J Surfact Deterg J Surfact Deterg (2020) 23: 553-563

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The Consumption of a Structured Triacylglycerol Containing Behenic and Oleic Acids Increases Fecal Fat Excretion in Humans

Cited by 11 publications

References 9 publications

Effects of Paramylon Extracted from Euglena gracilis EOD-1 on Parameters Related to Metabolic Syndrome in Diet-Induced Obese Mice

Effects of Paramylon Extracted from Euglena gracilis EOD-1 on Parameters Related to Metabolic Syndrome in Diet-Induced Obese Mice

Effects of liquid konjac on parameters related to obesity in diet-induced obese mice

Low‐Temperature Crystallization for Separating Monoacetylated Long‐Chain Sophorolipids: Characterization of Their Surface‐Active and Antimicrobial Properties

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