The construction of versatile azido-bridged Schiff base Copper(II) complexes with xanthine oxidase inhibitory activity

Zhang, Mei; Xian, Dong-Mei; Zhang, Na; Li, Haihua; Zhang, You

doi:10.1007/s11224-012-9956-7

Cited by 18 publications

(3 citation statements)

References 21 publications

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“…The link between copper and these systems highlights its importance in maintaining health, with recommended doses of 1.5-3.0 mg in adults and 1 mg in children [52]. High concentrations of copper [64] act as an enzyme inhibitor and limit the activity of alkaline phosphatase [65], catalase [22], xanthine oxidase [66] and ribonuclease [67,68].…”

Section: Introductionmentioning

confidence: 99%

<i>Drosophila melanogaster </i>as a Bioindicator in Comparative Copper and Lead Toxicology: Exploring the Health Implications of Heavy Metal Exposure

Sarac,

Onisan,

Petrescu

et al. 2024

Preprint

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Drosophila melanogaster serves as a important research model both for genetic investigations and for the study of metal toxicity, facilitating the elucidation of physiological mechanisms comparable to those of human organisms. In our research, we evaluated the toxicity effect resulting from exposure to various concentrations of lead and copper on the prolificity rates throughout the life cycle (egg-adult) of four genotypes of Drosophila melanogaster: wild-type (control), white, brown, and white-vestigial. During our study, the prolificity rates were examined across three repetitions under the impact of exposure to concentrations of 0.50, 1.00, 2.00, and 4.00 mM of copper (CuSO4) and lead (Pb(C2H3O2)2). Prolificity rates throughout the life cycle exhibited variations as a direct consequence of genetic factors, the concentration of exposure, and the specific type of metal, either copper or lead. The mutant white-vestigial genotype revealed an IC50 concentration for prolificity inhibition at lower doses of 2.00 mM for copper and 4.00 mM for lead, in contrast to the control genotype (wild-type), which exhibited an inhibition concentration rate >IC50 of 4.00 mM only in the case of copper. Our results concluded that the (i) dose influences the prolificity rate in a directly proportional manner, (ii) comparative analyses between copper and lead revealed that copper displayed toxicity across all genotypes within the concentration range of 0.50 mM to 2.00 mM. In contrast, lead exhibited toxicity within the concentration range of 1.00 mM to 4.00 mM, highlighting a (iii) more acute toxicity characteristic in the case of copper. Thus, the results of this research reflect the importance of using Drosophila melanogaster as a genetic model in the comparative study of the interaction between genetic factors and the toxicity of metals, offering significant insights into monitoring their impact and defining the maximum permissible doses on organisms.

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Section: Introductionmentioning

confidence: 99%

<i>Drosophila melanogaster </i>as a Bioindicator in Comparative Copper and Lead Toxicology: Exploring the Health Implications of Heavy Metal Exposure

Sarac,

Onisan,

Petrescu

et al. 2024

Preprint

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“…The interaction of simple vanadium species with organic ligands having pharmacological activity is of particular interest. Schiff -base compounds have been widely used as versatile ligands in coordination chemistry [6][7][8] and they have shown interesting biological properties, such as antibacterial, antitumor, and antifungal activities [9][10][11] as well as catalytic properties [12][13][14]. Also, several vanadium compounds have been investigated in animal model systems as treatment for diabetes [15][16], and studies are ongoing in clinical trials in human beings with organic transition metal complexes [17].…”

Section: Introductionmentioning

confidence: 99%

Metallopharmaceutical complexes based on vanadium as potential anti-hyperglycemic agents

et al. 2020

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I nteraction between vanadium pentoxide and bioactive Schiff-bases led to the formation of vanadium (III/IV) complexes. Ten complexes have been characterized using mass, IR, UV-VIS and ESR spectra, magnetic moments and conductance measurements as well as elemental and thermal analyses. Magnetic moments and ESR measurements confirmed vanadium complexes have (III/IV) oxidation state. Conductivity measurements indicate that complexes are not electrolytes. A representative set of vanadium (III/IV) complexes in varying coordination environments have been tested as anti-hyperglycemic agents against type 2 diabetes mellitus in concentration doses (30 and 100 µM/Kg) using female albino rats. The pharmacological data showed that, complexes 1 and 8 produced significant decrease in blood glucose level. Furthermore, these two complexes showed an improvement in liver and kidney function after daily administration for two weeks.

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“…The interaction of simple vanadium species with ligands having pharmacological activity is of particular interest. Schiff base compounds have been widely used as versatile ligands in coordination chemistry [4][5][6], and they have shown interesting biological properties, such as antibacterial, antitumor, and antifungi activities [7][8][9], as well as catalytic properties [10][11][12]. Recently, we have reported a few vanadium complexes [13].…”

Section: Introductionmentioning

confidence: 99%

Oxovanadium(V) Complexes With Schiff Base Ligands: Synthesis, Structure, and Catalytic Property

Wang

Guo

2013

Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-

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The reaction of [VO(acac) 2 ] with N,N'-ethylenebis(3-ethoxysalicylideneimine) (H 2 L 1 ) and N,N'-ethylenebis(3-methylsalicylideneimine) (H 2 L 2 ), respectively, in methanol, affords two new oxovanadium(V) complexes [VOL 1 ]·H 2 O (1) and [VOL 2 ] (2). Both complexes have been characterized by elemental analysis, i.r., and single crystal X-ray diffraction methods. The V atoms in the complexes are in distorted square pyramidal coordination. The dinegative Schiff base ligands coordinate to the metal atoms through phenolate and imine donor atoms. Both complexes have effective catalytic property for the sulfoxidation reaction.

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The construction of versatile azido-bridged Schiff base Copper(II) complexes with xanthine oxidase inhibitory activity

Cited by 18 publications

References 21 publications

<i>Drosophila melanogaster </i>as a Bioindicator in Comparative Copper and Lead Toxicology: Exploring the Health Implications of Heavy Metal Exposure

<i>Drosophila melanogaster </i>as a Bioindicator in Comparative Copper and Lead Toxicology: Exploring the Health Implications of Heavy Metal Exposure

Metallopharmaceutical complexes based on vanadium as potential anti-hyperglycemic agents

Oxovanadium(V) Complexes With Schiff Base Ligands: Synthesis, Structure, and Catalytic Property

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