The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells

McNeill, Elizabeth; Warinner, Chloe; Alkins, Stephen; Taylor, Alicia; Heggeness, Hansine; DeLuca, Todd; Fulga, Tudor A.; Wall, Dennis P.; Griffith, Leslie C.; Vactor, David Van

doi:10.1038/s41467-020-14761-8

Cited by 24 publications

(14 citation statements)

References 87 publications

(132 reference statements)

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“…Of note is the robust association of CAF22 with plasma miRs levels. All the miRs investigated by us have some degree of contribution in NMJ regulation and maintenance [ 42 , 43 , 44 ]. For example, miR-206 is involved in NMJ repair following nerve injury, and this action is either mediated alone or in combination with miR-133 [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…For example, miR-206 is involved in NMJ repair following nerve injury, and this action is either mediated alone or in combination with miR-133 [ 42 ]. Similarly, miR-34a regulated synaptogenesis by mediating the interaction between presynaptic and postsynaptic terminals [ 44 ]. The association of these miRs with CAF22 shows that they likely share signaling pathways involved in NMJ disruption in aging and respiratory diseases.…”

Section: Discussionmentioning

confidence: 99%

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Circulating Biomarkers of Accelerated Sarcopenia in Respiratory Diseases

Qaisar

Karim

Muhammad

et al. 2020

Biology

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Skeletal muscle dysfunction is a critical finding in many respiratory diseases. However, a definitive biomarker to assess muscle decline in respiratory diseases is not known. We analyzed the association of plasma levels of glycoprotein Dickkopf-3 (Dkk-3), c-terminal agrin fragment-22 (CAF22) and microRNAs miR-21, miR-134a, miR-133 and miR-206 with hand-grip strength (HGS) and appendicular skeletal mass index (ASMI) in male, 54–73-year-old patients with chronic obstructive pulmonary diseases (COPD), asthma or pulmonary TB (n = 83–101/group). Patients with respiratory diseases showed a reduction in HGS and gait speed, while a reduction in ASMI was only found in patients with pulmonary TB. Among the sarcopenia indexes, HGS showed the strongest correlation with plasma CAF22, miR-21 and miR-206 levels while ASMI showed the strongest correlation with Dkk-3 and miR-133 in respiratory diseases. We found a modest-to-significant increase in the plasma markers of inflammation, oxidative stress and muscle damage, which had varying degrees of correlations with Dkk-3, CAF22 and selected micro RNAs (miRs) in respiratory diseases. Taken together, our data show that plasma levels of Dkk-3, CAF22 and selected miRs can be useful tools to assess accelerated sarcopenia phenotype in the elderly with respiratory diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Circulating Biomarkers of Accelerated Sarcopenia in Respiratory Diseases

Qaisar

Karim

Muhammad

et al. 2020

Biology

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“…miRNAs are endogenous noncoding RNAs with regulatory functions that can recognize target mRNAs by base complementary pairing and then degrade target mRNAs or inhibit the translation of target mRNAs 23 .…”

Section: Discussionmentioning

confidence: 99%

Hsa_circ_0110757 upregulates ITGA1 to facilitate temozolomide resistance in glioma by suppressing hsa-miR-1298-5p

Liu

Chen

et al. 2021

Cell Death Dis

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Temozolomide (TMZ) is the internationally recognized and preferred drug for glioma chemotherapy treatment. However, TMZ resistance in glioma appears after long-term use and is an urgent problem that needs to be solved. Circular RNAs (circRNAs) are noncoding RNAs and play an important role in the pathogenesis and progression of tumors. Hsa_circ_0110757 was identified in TMZ-resistant glioma cells by high-throughput sequencing analysis and was derived from reverse splicing of myeloid cell leukemia-1 (Mcl-1) exons. The role of hsa_circ_0110757 in TMZ-resistant glioma was evaluated both in vitro and in vivo. It was found that hsa_circ_0110757 and ITGA1 are more highly expressed in TMZ-resistant glioma than in TMZ-sensitive glioma. The overexpression of hsa_circ_0110757 in glioma patients treated with TMZ was obviously associated with tumor invasion. This study indicates that hsa_circ_0110757 inhibits glioma cell apoptosis by sponging hsa-miR-1298-5p to promote ITGA1 expression. Thus, hsa_circ_0110757/hsa-miR-1298-5p/ITGA could be a potential therapeutic target for reversing the resistance of glioma to TMZ.

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“…TREAT 39 ) will have to be performed. 40 . miR-34 has also been implicated in stress-associated disorders, e.g.…”

Section: Discussionmentioning

confidence: 99%

Pervasive compartment-specific regulation of gene expression during homeostatic synaptic scaling

Colameo

Rajman

Soutschek

et al. 2020

Preprint

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Synaptic scaling is a form of homeostatic plasticity which allows neurons to adjust their action potential firing rate in response to chronic alterations in neural activity. Synaptic scaling requires profound changes in gene expression, but the relative contribution of local and cell-wide mechanisms is controversial. Here we performed a comprehensive multi-omics characterization of the somatic and process compartments of primary rat hippocampal neurons during synaptic scaling. Thereby, we uncovered both highly compartment-specific and correlated changes in the neuronal transcriptome and proteome. Whereas downregulation of crucial regulators of neuronal excitability occurred primarily in the somatic compartment, structural components of excitatory postsynapses were mostly downregulated in processes. Motif analysis further suggests an important role for trans-acting post-transcriptional regulators, including RNA-binding proteins and microRNAs, in the local regulation of the corresponding mRNAs. Altogether, our study indicates that compartmentalized gene expression changes are widespread in synaptic scaling and might co-exist with neuron-wide mechanisms to allow synaptic computation and homeostasis.

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The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells

Cited by 24 publications

References 87 publications

Circulating Biomarkers of Accelerated Sarcopenia in Respiratory Diseases

Circulating Biomarkers of Accelerated Sarcopenia in Respiratory Diseases

Hsa_circ_0110757 upregulates ITGA1 to facilitate temozolomide resistance in glioma by suppressing hsa-miR-1298-5p

Pervasive compartment-specific regulation of gene expression during homeostatic synaptic scaling

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