Hsa_circ_0110757 upregulates ITGA1 to facilitate temozolomide resistance in glioma by suppressing hsa-miR-1298-5p

Abstract

Temozolomide (TMZ) is the internationally recognized and preferred drug for glioma chemotherapy treatment. However, TMZ resistance in glioma appears after long-term use and is an urgent problem that needs to be solved. Circular RNAs (circRNAs) are noncoding RNAs and play an important role in the pathogenesis and progression of tumors. Hsa_circ_0110757 was identified in TMZ-resistant glioma cells by high-throughput sequencing analysis and was derived from reverse splicing of myeloid cell leukemia-1 (Mcl-1) exons. The role of hsa_circ_0110757 in TMZ-resistant glioma was evaluated both in vitro and in vivo. It was found that hsa_circ_0110757 and ITGA1 are more highly expressed in TMZ-resistant glioma than in TMZ-sensitive glioma. The overexpression of hsa_circ_0110757 in glioma patients treated with TMZ was obviously associated with tumor invasion. This study indicates that hsa_circ_0110757 inhibits glioma cell apoptosis by sponging hsa-miR-1298-5p to promote ITGA1 expression. Thus, hsa_circ_0110757/hsa-miR-1298-5p/ITGA could be a potential therapeutic target for reversing the resistance of glioma to TMZ.

circRNA hsa_circ_0005909 Predicts Poor Prognosis and Promotes the Growth, Metastasis, and Drug Resistance of Non-Small-Cell Lung Cancer via the miRNA-338-3p/SOX4 Pathway

“…In other words, circRNAs can bind miRNAs to suppress their expressions and competitively result in the suppression of the 13 Disease Markers interreaction between miRNAs and their potential targeting genes, thereby modulating tumor progression. For instance, circ_0110757 was reported to increase temozolomide resistance in neuroblastoma via sponging miRNA-1298-5p [25]. Circular RNA RHOT1 promoted metastasis and suppressed ferroptosis via the miR-106a-5p/STAT3 axis in breast cancer [26].…”

The Role of Circular RNAs in the Drug Resistance of Cancers

“…In glioma, exosomal circ_0072083 modulates NANOG and ALKBH5 by targeting miR-1252-5p and demethylation to control TMZ resistance ( 114 ). Hsa_circ_0110757 and circ_0005198 facilitate TMZ resistance and inhibit glioma cell apoptosis through the miR-1298-5p/ITGA1 and miR-198/TRIM14 axis, respectively ( 115 , 116 ). Consistent with these findings, downregulation of circ-VPS18, hsa_circ_0000936, circHIPK3, and circ CEP128 improve TMZ sensitivity and repress glioma progression ( 117 – 120 ).…”

LncRNAs and CircRNAs in cancer

“…Both hsa_circ_0110757 and circ_0072083 can enhance the temozolomide resistance in glioma. Differently, hsa_circ_0110757 sponged with hsa‐miR‐1298‐5p to increase the expression level of ITGA, 165 whereas circ_0072083 bound to miR‐1252‐5p to modulate NANOG and ALKBH5 166 …”