The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans

Shirayama, Masaki; Soto, Martha C.; Ishidate, Takao; Kim, Soyoung; Nakamura, Kyotaro; Bei, Yanxia; Heuvel, Sander van den; Mello, Craig C.

doi:10.1016/j.cub.2005.11.070

Cited by 96 publications

(110 citation statements)

References 39 publications

(64 reference statements)

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“…17,18 However, the phenotypes exhibited by these mutants were not simply caused by defects in cell cycle progression; for both mutants, the striking defects observed in cell fate specification occur in embryos that show an otherwise wild-type pattern and timing of cell division. 16 Consistent with these findings, when immunoprecipitated from embryonic lysates CDK-1(ne2257) was shown to phosphorylate Histone H1, a well-known CDK1 substrate during mitosis, at levels similar to that observed for wild-type CDK-1. 16 These observations suggest that the function of cdk-1 in cell fate specification can be uncoupled from its role in driving progression through the cell cycle.…”

Section: Cell Fate Specification Regulated By C Elegans Cdk1supporting

confidence: 62%

“…16 Consistent with these findings, when immunoprecipitated from embryonic lysates CDK-1(ne2257) was shown to phosphorylate Histone H1, a well-known CDK1 substrate during mitosis, at levels similar to that observed for wild-type CDK-1. 16 These observations suggest that the function of cdk-1 in cell fate specification can be uncoupled from its role in driving progression through the cell cycle.…”

Section: Cell Fate Specification Regulated By C Elegans Cdk1supporting

confidence: 62%

“…cdk-1(ne236 ) and cdk-1(ne2257) are 2 hypomorphic alleles of C. elegans CDK1 that were initially identified in forward genetic screens for embryonic lethal mutations exhibiting defects in cell fate specification. 16 These 2 unique alleles of CDK1, one non-conditional (ne236 ) and one temperature-sensitive (ne2257), exhibited essentially an identical phenotype, in which the founder cell "C" produces extra intestinal tissue instead of giving rise to hypodermis and body wall muscle. cdk-1 is essential for cell division.…”

Section: Cell Fate Specification Regulated By C Elegans Cdk1mentioning

confidence: 99%

“…Further genetic studies implicated cyclin B3 but not cyclin A in the regulation of OMA-1 stability. 16 Thus, a CDK-1/cyclin B3 complex promotes OMA-1 protein degradation during the first cell cycle to ensure proper cell fate specification in the initial asymmetric cell divisions of the C. elegans embryo.…”

Section: Cdk-1 Regulates the Transition From Oocyte To Embryo In Celmentioning

confidence: 99%

“…3A). 16 A set of biochemical experiments revealed that OMA-1 degradation is promoted by a series of sequential phosphorylations, initiated by a DYRK family kinase MBK-2, a kinase known to phosphorylate various substrates during oocyte-to-embryo transition, Figure 3. (A) Model for the role of CDK-1 in OMA-1 degradation during oocyte-to-embryo transition.…”

Section: Cdk-1 Regulates the Transition From Oocyte To Embryo In Celmentioning

confidence: 99%

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Divide and differentiate

et al. 2014

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Section: Cell Fate Specification Regulated By C Elegans Cdk1supporting

confidence: 62%

Section: Cell Fate Specification Regulated By C Elegans Cdk1supporting

confidence: 62%

Section: Cell Fate Specification Regulated By C Elegans Cdk1mentioning

confidence: 99%

Section: Cdk-1 Regulates the Transition From Oocyte To Embryo In Celmentioning

confidence: 99%

Section: Cdk-1 Regulates the Transition From Oocyte To Embryo In Celmentioning

confidence: 99%

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Divide and differentiate

et al. 2014

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Multiple functions of DYRK2 in cancer and tissue development

Yoshida

2019

FEBS Letters

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Dual‐specificity tyrosine‐regulated kinases (DYRKs) are evolutionarily conserved from yeast to mammals. Accumulating studies have revealed that DYRKs have important roles in regulation of the cell cycle and survival. DYRK2, a member of the class II DYRK family protein, is a key regulator of p53, and phosphorylates it at Ser46 to induce apoptosis in response to DNA damage. Moreover, recent studies have uncovered that DYRK2 regulates G1/S transition, epithelial‐mesenchymal‐transition, and stemness in human cancer cells. DYRK2 also appears to have roles in tissue development in lower eukaryotes. Thus, the elucidation of mechanisms for DYRK2 during mammalian tissue development will promote the understanding of cell differentiation, tissue homeostasis, and congenital diseases as well as cancer. In this review, we discuss the roles of DYRK2 in tumor cells. Moreover, we focus on DYRK2‐dependent developmental mechanisms in several species including fly (Drosophila), worm (Caenorhabditis elegans), zebrafish (Danio rerio), and mammals.

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Emerging roles of metazoan cell cycle regulators as coordinators of the cell cycle and differentiation

2020

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In multicellular organisms, cell proliferation must be tightly coordinated with other developmental processes to form functional tissues and organs. Despite significant advances in our understanding of how the cell cycle is controlled by conserved cell‐cycle regulators (CCRs), how the cell cycle is coordinated with cell differentiation in metazoan organisms and how CCRs contribute to this process remain poorly understood. Here, we review the emerging roles of metazoan CCRs as intracellular proliferation‐differentiation coordinators in multicellular organisms. We illustrate how major CCRs regulate cellular events that are required for cell fate acquisition and subsequent differentiation. To this end, CCRs employ diverse mechanisms, some of which are separable from those underpinning the conventional cell‐cycle‐regulatory functions of CCRs. By controlling cell‐type‐specific specification/differentiation processes alongside the progression of the cell cycle, CCRs enable spatiotemporal coupling between differentiation and cell proliferation in various developmental contexts in vivo. We discuss the significance and implications of this underappreciated role of metazoan CCRs for development, disease and evolution.

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The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans

Cited by 96 publications

References 39 publications

Divide and differentiate

Divide and differentiate

Multiple functions of DYRK2 in cancer and tissue development

Emerging roles of metazoan cell cycle regulators as coordinators of the cell cycle and differentiation

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