The consequence of NAC on sodium arsenite-induced uterine oxidative stress

Dash, Moumita; Maity, Moulima; Dey, Arindam; Perveen, Hasina; Khatun, Shamima; Jana, Lipirani; Chattopadhyay, Sandip

doi:10.1016/j.toxrep.2018.02.003

Cited by 26 publications

(19 citation statements)

References 84 publications

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“…1 in ovarian and uterine tissue. Modification of cysteine in SOD in response to redox imbalance might be plausible in the inactivation of SOD 25 . Arsenic also decreases the mRNA expression of the SOD gene in the way of generation of oxidative stress in response to decrease nullification of superoxide anion radicals (O2 .-) 26 .…”

Section: Resultsmentioning

confidence: 99%

Untitled

2019

IJPSR

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The present study was proposed to delineate the curative role of arjunolic acid and vitamin B 12 alone or in combination against arsenic induced oxidative stress and female reproductive dysfunction. The Wistar strain adult female rats were treated with sodium arsenite at the dose of 1.0 mg/100 gm body weight orally for first eight days. Next eight days rats were treated with arjunolic acid (1.0 mg/100 gm body weight) and vitamin B 12 (0.09 μg/100 gm body weight) orally. In ovarian and uterine tissue showed a recovery in arsenic induced ROS-production following the post-treatment of arjunolic acid and vitamin B 12. Antioxidant status was also improved by arjunolic acid and vitamin B 12 as established from the electrozymographic analysis of SOD, catalase and GPx. Post-treatment of these two significantly retrieved ovarian estradiol receptor 1 (ESR-1) from arsenic induced down regulation. Arjunolic acid and vitamin B 12 also showed its curative ability in improving the level of inflammatory markers such as NF-κB, metallothioneine-1 (MT-1), TNF-α, IL-6. Thus these two bioactive substances might have the curative role against arsenic induced female reproductive dysfunction. INTRODUCTION: The trioxide form of arsenic has the ability to react with cellular thiols to exert its toxicity and during the metabolism of thiols in cells reactive oxygen species generates which thereby promotes tissue damage 1. Arsenic is the cause of several reproductive hazards. It impairs spermatogenesis process and decreases the spermatogenetic enzymes in male reproductive system. The spermatogenic meiosis and the postmeiotic stages were altered by arsenic. Gonadal dysfunctions like declined testosterone synthesis, apoptotic and necrotic changes due to arsenic mediated oxidative damage 2 may cause male infertility.

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Section: Resultsmentioning

confidence: 99%

Untitled

2019

IJPSR

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“…The decrease in H 2 O 2 can be attributed to the ability of CAR and NAC to act as reactive oxygen species (ROS) scavengers. It can also be due to enhanced catalase activity in the combination groups, which will increase the rate of H 2 O 2 decomposition . NaNO 2 treatment also decreased the total sulfhydryl content and GSH level.…”

Section: Discussionmentioning

confidence: 98%

“…It exerts a protective effect by maintaining intracellular pool of GSH, scavenging ROS/RNS and enhancing the activities of main antioxidant enzymes. 10,35 Inside the cell, nitrite can form reactive nitrogen intermediates which combine with superoxide radicals to form peroxynitrite. NAC is known to protect against peroxynitrite-mediated cell damage.…”

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confidence: 99%

Ameliorative effect of carnosine and N‐acetylcysteine against sodium nitrite induced nephrotoxicity in rats

Ansari

Khan

Mahmood

2018

J of Cellular Biochemistry

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The widespread use of sodium nitrite (NaNO2) for various industrial purposes has increased human exposure to alarmingly high levels of nitrate/nitrite. Because NaNO 2 is a strong oxidizing agent, induction of oxidative stress is one of the mechanisms by which it can exert toxicity in humans and animals. We have investigated the possible protection offered by carnosine (CAR) and N‐acetylcysteine (NAC) against NaNO 2‐induced nephrotoxicity in rats. Animals orally received CAR at 100 mg/kg body weight/d for seven days or NAC at 100 mg/kg body weight/d for five days followed by a single oral dose of NaNO 2 at 60 mg/kg body weight. The rats were killed after 24 hours, and the kidneys were removed and processed for various analyses. NaNO 2 induced oxidative stress in kidneys, as shown by the decreased activities of antioxidant defense, brush border membrane, and metabolic enzymes. DNA‐protein crosslinking and DNA fragmentation were also observed. CAR/NAC pretreatment significantly protected the kidney against these biochemical alterations. Histological studies supported these findings, showing kidney damage in NaNO 2‐treated animals and reduced tissue impairment in the combination groups. The protection offered by CAR and NAC against NaNO 2‐induced damage, and their nontoxic nature, makes them potential therapeutic agents against nitrite‐induced nephrotoxicity.

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“…Other chemical materials, which were used in the paper, were of highest purity and were purchased from Sigma and Merck. The HSP and SA were based on the formerly searches by Ahmad et al () and Dash et al (), respectively.…”

Section: Methodsmentioning

confidence: 99%

“…Besides the natural sources, use of arsenic‐contaminating insecticides, herbicides, rodenticides, and by‐products of fossil fuels are also potent sources of arsenic toxicity (Gupta, Kannan, Sharma, & Flora, ). Arsenic contamination can lead to a wide variety of diseases such as cancers, liver and kidney diseases, neurologic disorder, diabetes mellitus, anemia, hypertension, cardiovascular disorders, male and female reproductive abnormalities (Dash et al, ; Momeni, Oryan, & Eskandari, ; Yousef, El‐Demerdash, & Radwan, ). In addition, arsenic targets various enzymatic reactions; it affects almost all organ systems in humans and other animals (Yousef et al, ).…”

Section: Introductionmentioning

confidence: 99%

The effects of hesperidin on sodium arsenite-induced different organ toxicity in rats on metabolic enzymes as antidiabetic and anticholinergics potentials: A biochemical approach

et al. 2018

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In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase‐1 (PON1), α‐glycosidase (α‐Gly), butyrylcholine esterase (BChE), acetylcholine esterase (AChE) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats. CA activities were significantly decreased in testis, liver, and heart tissues of rats given HSP, SA, SA+HSP‐100, and SA+HSP‐200 compared to control (p < 0.05). In liver tissue, AChE and BChE enzymes activities were significantly reduced given in all groups. In all tissues, α‐Gly activity was reduced given in all groups. In the current study, aldose reductase enzyme activity was reduced significantly in testis, brain, and heart tissues of all groups compared to standard (p < 0.05). PON1 enzyme activity was increased significantly in kidney and liver tissues of rats HSP groups and decreased SA groups compared to control. Practical applications α‐Glycosidase is the key enzyme involved in the digestion of the carbohydrate. Another enzyme α‐amylase hydrolyzes the α‐linked polysaccharide derivatives into oligosaccharide molecules, and α‐glycosidase enzymes, which are characterized in small intestine, catalyze the final stage in the digestive mechanism of carbohydrate molecule to release absorbable monosaccharides like glucose. Conforming to the cholinergic hypothesis, impairment of the cholinergic pathways plays a good role in the development of neurodegenerative diseases like depression, schizophrenia, Alzheimer's disease (AD) problems with the regulation of traumatic brain injury and sleep. The AD is the main reason for dementia disease, and mild to moderate cases are generally treated with AChE inhibitors. Human CA inhibitor compounds are clinically used for more than 70 years as antiglaucoma and diuretics drugs.

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The consequence of NAC on sodium arsenite-induced uterine oxidative stress

Abstract: Graphical abstract

Cited by 26 publications

References 84 publications

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Ameliorative effect of carnosine and N‐acetylcysteine against sodium nitrite induced nephrotoxicity in rats

The effects of hesperidin on sodium arsenite-induced different organ toxicity in rats on metabolic enzymes as antidiabetic and anticholinergics potentials: A biochemical approach

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