The Conjugated, Non-Protein, Amino Acids of Plasma. V. A Study of the Clinical Significance of Peptidemia

Christensen, Halvor N.; Decker, David G.; Lynch, Eleanor L.; Mackenzie, Thayer M.; Powers, John H.

doi:10.1172/jci101876

Cited by 25 publications

(7 citation statements)

References 11 publications

(8 reference statements)

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“…The manner of deproteinization and the dialysis experiments also tend to militate against the presence of peptides. This confirms the observations of Christensen and co-workers, who were unable to find an increase in nondialyzable a-amino N in deproteinized uremic plasma (39 (30). Since one organic acid, phenylacetic acid, is a constituent of one conjugate (peak C) it is conceivable that other conjugates (peaks A and B) represent conglomerates of amino acids with other organic substances.…”

Section: Discussionsupporting

confidence: 91%

Conjugated Amino Acids in Plasma of Patients With Uremia*

Frimpter¹,

Thompson²,

Luckey³

1961

J. Clin. Invest.

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Section: Discussionsupporting

confidence: 91%

Conjugated Amino Acids in Plasma of Patients With Uremia*

Frimpter¹,

Thompson²,

Luckey³

1961

J. Clin. Invest.

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“…A partial hydrolysate of bovine plasma proteins (Travamin® 3) was used as a sugar-free solution and one containing 5 per cent glucose. All preparations were indicated to be of 5 per cent strength, and analyzed by us for free and bound amino acids (Table I) The plasma and urine samples were analyzed for free and bound amino acids after removal of proteins (3,4). Some simplification of the technique should make the determination of bound amino acids of plasma more attractive to other investigators.…”

Section: Methodsmentioning

confidence: 99%

Effects of Simultaneous or Prior Infusion of Sugars on the Fate of Infused Protein Hydrolysates 12

Christensen¹,

Wilber²,

Coyne³

et al. 1955

J. Clin. Invest.

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Glucose usually is included in amino acid solutions for intravenous infusion. This has seemed desirable because the amino acids can spare body protein only when sufficient calories are provided. Although the calories so gained (usually 200 for a liter of hydrolysate) are far from enough for this purpose, they do add to the total and besides they might serve particularly efficiently being presented at the same time as the amino acids.On the other hand Elman and his co-workers (1) have reported improved retention of the nitrogen of a partial hydrolysate when fructose replaced the usual glucose. In explanation these writers suggest that the cellular uptake of the glucose is relatively too late to spare the amino acids optimally, whereas the fructose is metabolized more quickly.The present study was undertaken to compare the effects of glucose and fructose on the fate of the amino acids and peptides of infused hydrolysates. We have found that the presence of either sugar in certain commercial protein hydrolysates interferes with the tissue utilization of the peptides present; the effect increases in the order 10 per cent fructose, 5 per cent glucose, 10 per cent glucose. It is completely avoided if the sugars are added to the hydrolysate sterilely just before infusion or if the sugars are infused in advance of the hydrolysate. Therefore, we conclude that substances which interfere with peptide utilization are formed during autoclaving by interaction between the sugars and constituents of the hydrolysate.

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“…A possible clinical significance of peptidaemia was at one time debated, but no firm conclusions were reached (e.g. Christensen, Decker, Lynch, Mackenzie & Powers, 1947. See also Matthews & Payne, 1975).…”

Section: Discussionmentioning

confidence: 99%

ABSORPTION OF INTACT PEPTIDES: STUDIES ON TRANSPORT OF PROTEIN DIGESTS AND DIPEPTIDES ACROSS RAT SMALL INTESTINE IN VITRO

Gardner

1982

Exp Physiol

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Passage of intact peptides across isolated rat small intestine has been studied during luminal perfusion with partial digests of proteins or with dipeptides. Significant passage of intact peptide does occur, the amount depending upon the luminal concentration. It probably reflects the ‘digestibility’ of the protein or protein digest. Previous studies are discussed and, although intact peptide transport is probably not of major nutritional importance, it is suggested that the pathophysiological significance of this process and of peptidaemia merits further attention.

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The Conjugated, Non-Protein, Amino Acids of Plasma. V. A Study of the Clinical Significance of Peptidemia

Cited by 25 publications

References 11 publications

Conjugated Amino Acids in Plasma of Patients With Uremia*

Conjugated Amino Acids in Plasma of Patients With Uremia*

Effects of Simultaneous or Prior Infusion of Sugars on the Fate of Infused Protein Hydrolysates 12

ABSORPTION OF INTACT PEPTIDES: STUDIES ON TRANSPORT OF PROTEIN DIGESTS AND DIPEPTIDES ACROSS RAT SMALL INTESTINE IN VITRO

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