The composition of the liver lipids of sheep and the effect of early sporidesmin poisoning

Peters, JA; Smith, LM

doi:10.1042/bj0920379

Cited by 28 publications

(5 citation statements)

References 23 publications

(12 reference statements)

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“…Phosphatidyl ethanolamine and phosphatidyl choline consti-Dated 46% and 35% respectively of the liver phospholipids at birth, but in the liver phospholipids of the adult sheep the proportion of phosphatidyl choline far exceeded that of phosphatidyl ethanolamine. Our results for the phosphatidyl choline and phosphatidyl ethanolamine contents of the liver phospholipids of adult sheep are similar to those obtained in other laboratories (13,14). The relative proportions of phosphatidyl choline and phosphatidyl ethanolamine in adult sheep liver would appear to be similar to those reported for cow liver (15).…”

Section: Resultssupporting

confidence: 91%

Postnatal changes in the phospholipid composition of livers from young lambs

Noble

Steele

Moore

1971

Lipids

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The total lipids were extracted from the livers of newborn lambs, from the livers of lambs during the first week after birth and from the livers of adult sheep. After separation from the nonphospholipids on columns of silicic acid the phospholipids were analyzed by thin layer chromatography and quantitative gas liquid chromatography. In all samples phosphatidyl choline and phosphatidyl ethanolamine together accounted for about 80% of the total liver phospholipids. The phosphatidyl choline-phosphatidyl ethanolamine ratio in the livers of the newborn iambs was markedly less than the ratio in the livers of the adult sheep. Moreover there was a pronounced increase in the phosphatidyl cholinephosphatidyl ethanolamine ratio in the livers of the lambs during the first week after birth. In the liver phospholipids of the lambs the concentration of phosphatidyl inositol was lower and the concentrations of phosphatidyl serine and sphingomyelin were greater than the corresponding concentrations in the liver phospholipids of the adult sheep. It is proposed that the change in the phosphatidyl choline-phosphatidyl ethanolamine ratio in the livers of the lambs during the first week after birth is due, at least in part, to the marked change that occurs in the linoleic acid-arachidonic acid ratio in the tissues of the lamb during this period.

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Section: Resultssupporting

confidence: 91%

Postnatal changes in the phospholipid composition of livers from young lambs

Noble

Steele

Moore

1971

Lipids

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“…The fat-free residue was dried at 100 °C to constant weight. The lipids from the muscular tissue were extracted by the Bligh & Dyer (1959) procedure as modified by Peters & Smith (1964).…”

Section: Methodsmentioning

confidence: 99%

A comparison of the effects of white clover (Trifolium repens) and of perennial ryegrass (Lolium perenne) on fat composition and flavour of lamb

Cramer

Barton

Shorland³

et al. 1967

J. Agric. Sci.

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1. The carcass composition, the composition and characteristics of the subcutaneous and longissimus dorsi muscle fats, the volatile fatty acids of the rumen-reticulum fluid and the degree of flavour and odour of the cooked 12th rib chops of two groups each of fifteen Southdown–Romney cross ewe and wether lambs fed respectively white clover and perennial ryegrass have been determined. The lambs had been on treatment for 5 months and were slaughtered when about 9 months of age.2. The white clover-fed lambs had a mean live weight at slaughter of 94 lb ± 9 lb compared with 67 lb ± 7 lb for the perennial ryegrass-fed lambs. The carcasses of the white clover-fed lambs had greater (P < 0·01) amounts of fat.3. The iodine values of the subcutaneous fats of the white clover-fed lambs were highly significantly greater than those of the ryegrass-fed lambs and this result was consistent with the greater deposition of endogenous fat.4. The extra fatness of the white clover-fed lambs was consistent with their greater production of rumen-reticulum volatile fatty acids.5. The maj or differences in fatty acid composition of subcutaneous and intramuscular fats between pasture treatments were the highly significant increases in shorter-chain saturated and C15 branched-chain acids of the ryegrass-fed lambs. In addition, the subcutaneous fat of the ryegrass group contained highly significantly more octadecadienoic and octadecatrienoic acids while the 1. dorsi fat of the ryegrass group was highly significantly richer in stearic and oleic acids.

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“…Considerable information is available from short-term investigations on the fatty infiltrations of the liver which result from the action of hepatotoxins in monogastric animals (see, e.g., Peters 1963). An analogous change occurs in the livers of sheep after dosing sporidesmin (Peters 1963;Peters and Smith 1964).…”

Section: Discussionmentioning

confidence: 95%

“…Thus, histopathological (Mortimer 1963) and clinical observations (Done, Mortimer, and Taylor 1962;Mortimer 1962), and the more outstanding biochemicall changes have been recorded and interpreted (Mortimer. Taylor, and Shorland 1962;Peters 1963;Peters and Smith 1964;Peters in press).…”

Section: Introduction 137mentioning

confidence: 99%

The effect of cholestyramine on sporidesmin intoxication in sheep

Peters¹,

Mortimer²

1966

New Zealand Journal of Agricultural Research

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Daily administration (0.8 g per kg of bodyweight) of cholestyramine, a bile acid-binding anion exchange resin, appears to affect the course of the disease produced by dosing sheep with the toxic fungal metabolite, sporidesmin (1 mg per kg bodyweight). Cholestyramine has no detrimental effect on normal sheep.It is suggested that the beneficial effects of cholestyramine on sporidesmin intoxication may be improved by changes in the experimental conditions.

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The composition of the liver lipids of sheep and the effect of early sporidesmin poisoning

Cited by 28 publications

References 23 publications

Postnatal changes in the phospholipid composition of livers from young lambs

Postnatal changes in the phospholipid composition of livers from young lambs

A comparison of the effects of white clover (Trifolium repens) and of perennial ryegrass (Lolium perenne) on fat composition and flavour of lamb

The effect of cholestyramine on sporidesmin intoxication in sheep

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