Postnatal changes in the phospholipid composition of livers from young lambs

Noble, R. C.; Steele, W.; Moore, J. H.

doi:10.1007/bf02531176

Cited by 10 publications

(1 citation statement)

References 24 publications

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“…Allowing for an ever increasing requirement of I g linoleic acid/kg tissue growth, the calf would still need only approximately 3 d to make up any deficit. Though Noble, Steele & Moore (1970) have reported the content of linoleic acid in sheep milk to be about 7 g/kg milk fatty acids in the first few days after birth, sheep milk 24 h after birth in New Zealand has been found to contain 20-30 g/kg milk fatty acids (Payne, unpublished results). Hence, there is about 2 g linoleic acid/l milk on the basis of 80 g milk fat11 milk.…”

Section: Replenishment O F Pufa In Newborn Ruminants By Milk Intakementioning

confidence: 99%

The polyunsaturated fatty acid status of foetal and neonatal ruminants

Payne¹

1978

Br J Nutr

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1. Information on the fatty acid composition of tissues of foetal calves, neonatal lambs, deer and piglets reported by Payne (1978) has been quantified by the use of an internal standard during analysis, to give concentrations of total polyunsaturated fatty acids (PUFA) derived from linoleic acid (ω6) and linolenic acid (ω3) expressed on a per kg tissue basis. The total concentration of both acids (ω6+ω3) was similar in all tissues examined except brain. Because muscle, the main constituent of the soft tissues of young animals, contains about 40–50 % of the total body content of these acids, it is considered that muscle concentrations are a reflection of total body status of these acids.2. Concentrations in muscle of both ω6 derivatives and total PUFA were significantly lower in the neonatal lamb and foetal calf than in the mature animal whereas in pigs and deer the concentrations in the young animal were similar to those in the mature animal. Concentrations of ω6 derivatives and total PUFA in lambs were significantly lower than those in calves; the presence of ω3 derivatives reduced the level of significance for total PUFA. Again, total PUFA content did not differ significantly between the piglet and the young ruminants.3. There was a substantial placental transfer, with apparently a preferential transfer of ω3 derivatives.4. In brain the levels of ω3 acids were as high in the foetal and neonatal animals as in mature animals. The levels of ω6 acids were lower in young animals.5. Calculations of ω6 intake from milk showed that the total deficit of ω6 could be made up within a few days.6. It was concluded that the extent of deficiency of ω6 in young ruminants raised in a grazing situation, as in New Zealand, is marginal and any feeding to overcome this is unlikely to be of any benefit.

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Section: Replenishment O F Pufa In Newborn Ruminants By Milk Intakementioning

confidence: 99%

The polyunsaturated fatty acid status of foetal and neonatal ruminants

Payne¹

1978

Br J Nutr

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The fatty acid composition of the main phospholipid fractions of the rumen and abomasum tissues of foetal and adult sheep

Body¹,

Shorland²

1974

J Sci Food Agric

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The fatty acid composition has been determined on phosphatidyl choline, phosphatidyl ethanolamine and sphingomyelin fractions earlier isolated from the rumen and abomasum tissues of foetal and of adult Romney sheep.The major proportion of polyunsaturated fatty acids was found in the phosphatidyl ethanolamine (17 to 43 %) fraction and this was reduced in the phosphatidyl choline (7 to 25 %) and sphingomyelin (1 to 4 %) fractions. These features are in keeping with the results for mammalian tissues generally. The phosphatidyl ethanolamine fractions were further characterised by the low content of palmitic acid (4 %) compared with 25 to 30% in the phosphatidyl choline fractions and 29 to 52 % in the sphingomyelin fractions and by the occurrence of cyclopropane fatty acids. Consistent with the findings of other workers on mammalian tissues, the sphingomyelin fractions contained a relatively high content (16 to 27%) of higher maturated fatty acids including 22: 0,23 : 0,24: 0 and 25 : 0 and of tetracos-14-enoic (24: 1 w9) acid (5 to 16%). The total amounts of acids above Czo tended to vary inversely with the levels of palmitic acid whereas the levels of stearic acid were relatively constant at 13 to 17%. Changes in fatty acid composition with age were generally not marked but the tissues of the foetus were distinguished from those of the adult by their substantial amount of eicosa-5,8,1l-trienoic (20: 3 09) acid together with relatively low contents of linoleic (18: 2 w6) and linolenic (1 8: 3 w3) acids and to a lesser extent by reduced level of acids of the w3 series. This was particularly reflected by the ratios of w6/w3 Czo + Cz2 acids in the phosphatidyl ethanolamine fractions, the values for the foetal rumen and abomasum tissues being 1.03 and 1.07, respectively, compared with corresponding values of 0.78 and 0.72 found in adult sheep.The results are consistent with a requirement for Czo and C,, polyunsaturated acids of the w3 and w6 series and some penetration of maternal fatty acids through the placenta. The resemblance between the fatty acid make-up and composition of foetal and maternal phospholipids suggests the possibility of transference of intact or lyso-phospholipids from the mother to the foetus through the placenta. However, such a possibility is counter-indicated by consideration of previous work using labelled intermediates and by the mechanism of conversion of linoleic and linolenic acids requiring their CoA derivatives in the formation of the corresponding polyunsaturated Cz0 4 Czz acids. Nevertheless, the sharp cut-off of exogenous maternal fatty acids from the foetal triglycerides and their inclusion in the foetal phospholipids are not readily explainable.

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Fatty Acid Metabolism in the Neonatal Ruminant

Noble

Shand

1982

Advances in Nutritional Research

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Postnatal changes in the phospholipid composition of livers from young lambs

Cited by 10 publications

References 24 publications

The polyunsaturated fatty acid status of foetal and neonatal ruminants

The polyunsaturated fatty acid status of foetal and neonatal ruminants

The fatty acid composition of the main phospholipid fractions of the rumen and abomasum tissues of foetal and adult sheep

Fatty Acid Metabolism in the Neonatal Ruminant

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