The composition of fusogenic lipid mixtures at the air-water modulates the physicochemical properties changes upon interaction with lysicamine

Machado, André Campos; Silva, Tamiris Reissa Cipriano da; Raminelli, Cristiano; Caseli, Luciano

doi:10.1016/j.bpc.2022.106947

Cited by 3 publications

(2 citation statements)

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“…This interfacial tension, known as surface tension, can significantly affect droplet size and stability in emulsions. 65 In this context, lower surface tension promotes smaller droplet formation and improved stability, while higher surface tension produces the opposite effect. LDs, similar to oilwater emulsions, comprise a suspension (cytoplasm) and oil (NLs) stabilised by a surfactant (PL monolayer).…”

Section: Droplet-embedded Vesicle Modelmentioning

confidence: 99%

“…Incompatibility between oil and water is a well‐established physical phenomenon, which necessitates a large energy investment to create an interface between them. This interfacial tension, known as surface tension, can significantly affect droplet size and stability in emulsions 65 . In this context, lower surface tension promotes smaller droplet formation and improved stability, while higher surface tension produces the opposite effect.…”

Section: Two Models Of Synthetic Lipid Dropletsmentioning

confidence: 99%

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Application of synthetic lipid droplets in metabolic diseases

Zhao,

et al. 2023

Clinical & Translational Med

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BackgroundThe study and synthesis of membrane organelles are becoming increasingly important, not only as simplified cellular models for corresponding molecular and metabolic studies but also for applications in synthetic biology of artificial cells and drug delivery vehicles. Lipid droplets (LDs) are central organelles in cellular lipid metabolism and are involved in almost all metabolic processes. Multiple studies have also demonstrated a high correlation between LDs and metabolic diseases. During these processes, LDs reveal a highly dynamic character, with their lipid fraction, protein composition and subcellular localisation constantly changing in response to metabolic demands. However, the molecular mechanisms underlying these functions have not been fully understood due to the limitations of cell biology approaches. Fortunately, developments in synthetic biology have provided a huge breakthrough for metabolism research, and methods for in vitro synthesis of LDs have been successfully established, with great advances in protein binding, lipid function, membrane dynamics and enzymatic reactions.Aims and methodsIn this review, we provide a comprehensive overview of the assembly and function of endogenous LDs, from the generation of lipid molecules to how they are assembled into LDs in the endoplasmic reticulum. In particular, we highlight two major classes of synthetic LD models for fabrication techniques and their recent advances in biology and explore their roles and challenges in achieving real applications of artificial LDs in the future.

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Section: Droplet-embedded Vesicle Modelmentioning

confidence: 99%

Section: Two Models Of Synthetic Lipid Dropletsmentioning

confidence: 99%