The composition and metabolism of large and small LDL

Diffenderfer, Margaret R.; Schaefer, Ernst J.

doi:10.1097/mol.0000000000000067

Cited by 127 publications

(92 citation statements)

References 55 publications

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“…Similar results were found in patients with premature CAD [27]. Besides, numerous investigations regarded the subfractions of LDL particles, assayed by sdLDL-C, as a more significant independent determinant of CAD risk than LDL-C [28]. In the current study, the negative association of SUA with large HDL-C and positive association with sdLDL-C may provide novel evidence for understanding the relationship between SUA and CAD susceptibility.…”

Section: Tablesupporting

confidence: 85%

Lipoprotein subfractions partly mediate the association between serum uric acid and coronary artery disease

Zhang

et al. 2015

Clinica Chimica Acta

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Section: Tablesupporting

confidence: 85%

Lipoprotein subfractions partly mediate the association between serum uric acid and coronary artery disease

Zhang

et al. 2015

Clinica Chimica Acta

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“…This indicated that for a given non-HDL-C level, an increase in LDL-C was associated with a reduced risk of long-term MACEs. It is well-established that the large LDL particle is associated with the lower risk of cardiovascular events than the small dense LDL particle [15]. The inverse association between LDL-C and long-term MACEs observed in the present study may be explained by the fact that patients with higher LDL-C level had larger LDL particle size than those with lower LDL-C level after adjustment with non-HDL-C level.…”

Section: Discussionsupporting

confidence: 42%

Is non-HDL-cholesterol a better predictor of long-term outcome in patients after acute myocardial infarction compared to LDL-cholesterol? : a retrospective study

Wongcharoen

Sutthiwutthichai

Gunaparn

et al. 2017

BMC Cardiovasc Disord

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BackgroundIt has recently been shown that non-high density lipoprotein cholesterol (non-HDL-C) may be a better predictor of cardiovascular risk than low density lipoprotein cholesterol (LDL-C). Based on known ethic differences in lipid parameters and cardiovascular risk prediction, we sought to study the predictability of attaining non-HDL-C target and long-term major adverse cardiovascular event (MACE) in Thai patients after acute myocardial infarction (AMI) compared to attaining LDL-C target.MethodsWe retrospectively obtained the data of all patients who were admitted at Maharaj Nakorn Chiang Mai hospital due to AMI during 2006–2013. The mean non-HDL-C and LDL-C during long-term follow-up were used to predict MACE at each time point. The patients were classified as target attainment if non-HDL-C <100 mg/dl and/or LDL-C <70 mg/dl. The MACE was defined as combination of all-cause death, nonfatal coronary event and nonfatal stroke.ResultsDuring mean follow-up of 2.6 ± 1.6 years among 868 patients after AMI, 34.4% achieved non-HDL-C target, 23.7% achieved LDL-C target and 21.2% experienced MACEs. LDL-C and non-HDL-C were directly compared in Cox regression model. Compared with non-HDL-C <100 mg/dl, patients with non-HDL-C of >130 mg/dl had higher incidence of MACEs (HR 3.15, 95% CI 1.46–6.80, P = 0.003). Surprisingly, LDL-C >100 mg/dl was associated with reduced risk of MACE as compared to LDL <70 mg/dl (HR 0.42, 95% CI 0.18–0.98, p = 0.046) after direct pairwise comparison with non-HDL-C level.ConclusionsNon-attaining non-HDL-C goal predicted MACE at long-term follow-up after AMI whereas non-attaining LDL-C goal was not associated with the higher risk. Therefore, non-HDL-C may be a more suitable target of dyslipidemia treatment than LDL-C in patients after AMI.Electronic supplementary materialThe online version of this article (doi:10.1186/s12872-016-0450-9) contains supplementary material, which is available to authorized users.

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“…However, treatment with the DS technique was associated with a significant decrease in LDL‐PPD and a tendency to reduce LDL particle size. Small, dense LDL (sdLDL) particles (<255 Å) have been shown to be more atherogenic, and an increase in the relative proportion of sdLDL has been correlated with higher CVD risk . These results are in contrast with a previous findings by Schamberger et al who reported a significant reduction in sdLDL particles and a significant increase in large LDL particles following apheresis treatment with both HELP and DS techniques in 16 FH subjects.…”

Section: Discussionmentioning

confidence: 75%

Comparison of two low‐density lipoprotein apheresis systems in patients with homozygous familial hypercholesterolemia

Drouin‐Chartier

Tremblay

Bergeron

et al. 2015

J of Clinical Apheresis

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Low-density lipoprotein (LDL) apheresis (LA) is a reliable method to decrease LDL-C concentrations and remains the gold standard therapy in homozygous familial hypercholesterolemia (HoFH). The objective of this study was to compare the efficacy of two LA systems [heparin-induced extracorporeal LDL precipitation (HELP) vs. dextran sulfate adsorption (DS) on the reduction of lipids, inflammatory markers, and adhesion molecules in a sample of genetically defined HoFH subjects (n = 9)]. Fasting blood samples were collected before and after LA. All subjects served as their own control and were first treated with the HELP system then with DS in this single sequence study. Compared with HELP, DS led to significantly greater reductions in total cholesterol (-63.3% vs. -59.9%; P = 0.05), LDL-C (-70.5% vs. -63.0%; P = 0.02), CRP (-75.3% vs. -48.8%; P < 0.0001), and TNF-α (-23.7% vs. +14.7%; P = 0.003). Reductions in the plasma levels of PCSK9 (-45.3% vs. -63.4%; P = 0.31), lipoprotein (a) (-70.6% vs. -65.0%; P = 0.30), E-selectin (-16.6% vs. -18.3%; P = 0.65), ICAM-1 (-4.0 vs. 5.6%; P = 0.56), and VCAM-1 (8.3% vs. -1.8%; P = 0.08) were not different between the two systems. For the same volume of filtered plasma (3,000 mL), however, HELP led to greater reductions in plasma apoB (-63.1% vs. -58.3%; P = 0.04), HDL-C (-20.6% vs. -6.5%; P = 0.003), and PCSK9 (-63.4% vs. -28.5%; P = 0.02) levels. These results suggest that both LA systems are effective in reducing plasma lipids and inflammatory markers in HoFH. Compared with HELP, greater reductions in lipid levels and inflammatory markers were achieved with DS, most likely because this method allows for a larger plasma volume to be filtered. J. Clin. Apheresis 31:359-367, 2016. © 2015 Wiley Periodicals, Inc.

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The composition and metabolism of large and small LDL

Abstract: Progress in our understanding of the composition and metabolism of LDL subfractions strengthens the association between sdLDL and CHD risk.

Cited by 127 publications

References 55 publications

Lipoprotein subfractions partly mediate the association between serum uric acid and coronary artery disease

Lipoprotein subfractions partly mediate the association between serum uric acid and coronary artery disease

Is non-HDL-cholesterol a better predictor of long-term outcome in patients after acute myocardial infarction compared to LDL-cholesterol? : a retrospective study

Comparison of two low‐density lipoprotein apheresis systems in patients with homozygous familial hypercholesterolemia

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