Lipoprotein subfractions partly mediate the association between serum uric acid and coronary artery disease

Hyperuricemia is Associated with Increased Apo AI Fractional Catabolic Rates and Dysfunctional HDL in New Zealand Rabbits

“…Moreover, glucose plasma levels during treatment remained comparable to basal values, indicating that OA did not affect insulin sensitivity as previously reported in rats [32]. Hyperuricemia and altered profile of HDL subclasses coexist in some pathological circumstances [10,16,29]. However, the confluences of different conditions, which affect HDL metabolism in patients, lead to the independency of the relationship between uric acid and HDL.…”

“…Then, rabbits emerged as a more suitable model for our objectives; based on the biochemical profile and urinary protein excretion that were comparable to the basal levels, renal function remained unchanged during OA treatment. Hyperuricemia and altered profile of HDL subclasses coexist in some pathological circumstances [10,16,29]. Moreover, glucose plasma levels during treatment remained comparable to basal values, indicating that OA did not affect insulin sensitivity as previously reported in rats [32].…”

“…In conclusion, hyperuricemia is associated with structural and metabolic modifications of HDL that result in impaired functionality Zhang et al demonstrated an altered high-density lipoproteins (HDL) subclasses profiles in patients with CAD [10]; since HDL subclasses are determined by the structure of these lipoproteins, and such HDL structure, in turn, may be associated with their catabolic rates [11], it is likely that high plasma levels of uric acid are associated with an altered HDL turnover. Therefore, this study aimed to explore the effect of oxonic acid (OA)-induced hyperuricemia on the HDL size distribution, lipid content of HDL subclasses, and apo AI turnover, as well as HDL functionality in New Zealand white rabbits.…”

“…Such structural and metabolic changes were associated with lower levels of PON-1 activities and deleterious effects of HDL particles on endothelium-mediated vasodilation. In conclusion, hyperuricemia is associated with structural and metabolic modifications of HDL that result in impaired functionality Zhang et al demonstrated an altered high-density lipoproteins (HDL) subclasses profiles in patients with CAD [10]; since HDL subclasses are determined by the structure of these lipoproteins, and such HDL structure, in turn, may be associated with their catabolic rates [11], it is likely that high plasma levels of uric acid are associated with an altered HDL turnover. In addition, an altered structure of HDL may be associated with impaired antiatherogenic functions of these lipoproteins [12].…”

HDL cholesterol subclasses are associated with serum uric acid in Japanese men

“…In order to prevent the incidence of the above disorders, it is important to investigate the influence of individual risk factors and to understand the interrelationships of various risk factors with UA. Previous reports suggested a negative relationship between UA and high-density lipoprotein cholesterol (HDL-C) levels 5,6) , however, interactions between UA and HDL-C subclasses are not well understood.…”