The complex health profile of long-term cancer survivors: prevalence and predictors of comorbid conditions

Leach, Corinne R.; Weaver, Kathryn E.; Aziz, Noreen M.; Alfano, Catherine M.; Bellizzi, Keith M.; Kent, Erin E.; Forsythe, Laura P.; Rowland, Julia H.

doi:10.1007/s11764-014-0403-1

Cited by 185 publications

(165 citation statements)

References 36 publications

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“…Current epidemiologic evidence strongly suggests that regular exercise is not only safe and feasible during cancer treatment and throughout survivorship, but that it can result in an improved quality of life [22]. Moreover, as shown in this study and previous studies [23,24], cancer survivors have a number of comorbid conditions, such as cardiovascular disease and diabetes, that may be improved with regular physical activity [25]. Both the ACS and NCCN recommend avoiding physical inactivity throughout the continuum of cancer care [9,26].…”

Section: Discussionsupporting

confidence: 77%

Lifestyle behaviors among US cancer survivors

et al. 2016

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Section: Discussionsupporting

confidence: 77%

Lifestyle behaviors among US cancer survivors

et al. 2016

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“…Survivors 10-14 years since cancer diagnosis are reporting significantly higher total numbers of health problems compared with those only 4-9 years past diagnosis [9]. Although younger age at diagnosis is often associated with more distress and poorer mental health, older cancer survivors represent a vulnerable population because late effects of cancer and its treatment could easily be attributed to advancing age and potentially be dismissed.…”

Section: Discussionmentioning

confidence: 99%

“…Although younger age at diagnosis is often associated with more distress and poorer mental health, older cancer survivors represent a vulnerable population because late effects of cancer and its treatment could easily be attributed to advancing age and potentially be dismissed. In the elderly, geriatric syndromes such as hearing trouble, urinary incontinence, falls, depression, and osteoporosis are more prevalent among cancer survivors than controls [9].…”

Section: Discussionmentioning

confidence: 99%

“…After adjustment for age, survivors 10-14 years past diagnosis report significantly higher total numbers of such conditions compared to those up to 10 years past diagnosis. This increase in long-term effects most likely reflects treatment-related late complications [9]. Bothersome symptoms such as fatigue, depression, sleep disorders, and pain, are highly prevalent and have a major impact on overall quality of life (QoL) in short-term survivors as well as in LTSs [10].…”

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confidence: 99%

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Quality of life in long-term and very long-term cancer survivors versus population controls in Germany

et al. 2017

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Background: With the increasing number and diversity of cancer survivors, studies of survivors' physical, emotional, and social health are of growing importance. While there is a growing body of literature on the quality of life (QoL) of cancer patients during the early years past diagnosis, less is known regarding QoL in long-term survivors (LTS) (5 þ years past diagnosis) and particularly in very long-term survivors (VLTS) (10 þ years past diagnosis). The objective of our study is to: (1) compare QoL of long-term cancer survivors and population norms; and (2) assess whether any deficits in QoL of survivors observed 5-10 years past diagnosis persist beyond the 10th year past diagnosis. Methods: In total 6952 long-term cancer survivors (5-16 years past diagnosis of breast, colorectal, or prostate cancer) from Germany recruited in the context of the population-based CAESAR þ study were compared with 1878 population-based controls without a history of cancer. QoL was assessed with the EORTC QLQ-C30. Differences in QoL between survivors and controls were assessed via multiple regression while controlling for age, gender, education, and case mix for survivors 5-9 years and 10 þ years past diagnosis separately. Results: Overall QoL in long-term cancer survivors was comparable to population norms but specific deficits in social, role, emotional, cognitive, and physical functioning and symptoms such as insomnia, fatigue, dyspnea, constipation, diarrhea, and financial difficulties were more prevalent in LTSs. Detriments in QoL persisted during the observation period and affected particularly cancer survivors at younger ages (<50 years). Non-significant aggravations in QoL with longer time since diagnosis were observed in very young and very old cancer survivors. Conclusions: Detriments in health-related quality of life persist over more than a decade and affect predominantly younger patients. Improvements both in early and long-term follow-up care of cancer survivors seem warranted.

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“…While they often report making health behaviour changes (Demark-Wahnefried et al, 2005), evidence of such changes is limited (Kim et al, 2013, Milliron et al, 2014, Williams et al, 2013b. Compared to survivors of other cancer sites, endometrial and breast cancer survivors have the highest comorbidity burden post-diagnosis (Leach et al, 2014) and gynaecologic (endometrial and ovarian) cancer survivors are less likely to be physically active compared to breast cancer survivors (Weaver et al, 2013). Given that lifestyle advice is scarce in current practice (Jernigan et al, 2013, Nicolaije et al, 2012, there may be a need to support endometrial cancer survivors in making appropriate healthy lifestyle changes.…”

Section: Introductionmentioning

confidence: 99%

Attitudes, challenges and needs about diet and physical activity in endometrial cancer survivors: a qualitative study

et al. 2016

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With rates of endometrial cancer survival increasing, there is growing interest about lifestyle behaviours that could improve quality of life and reduce the risk for chronic diseases. The current study aimed to explore the attitudes, challenges, and needs of endometrial cancer survivors regarding diet and physical activity. Sixteen UK-based endometrial cancer survivors participated in two focus groups (n=5, n=3) or individual telephone interviews (n=8), using a semi-structured interview guide. Data were collectively analysed by two researchers until consensus was reached on a coding structure. Data analysis proceeded until themes were identified. Participants were within five years post cancer treatment with median age and BMI of 57 years and 25.83kg/m 2 , respectively. Three themes were identified: i) defining a healthy lifestyle, ii) factors influencing diet and physical activity, and iii) needing to search for information. Results suggest interventions should incorporate recommendations on managing late-treatment effects, and behaviour change techniques for cognitive, practical, and social barriers to healthy lifestyle changes. Health care professionals are in a vital position to provide or introduce endometrial cancer survivors to in-person behaviour change interventions at the early post-treatment period.

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The complex health profile of long-term cancer survivors: prevalence and predictors of comorbid conditions

Abstract: Survivors may benefit when health professionals recommend specific strategies to achieve a healthy weight and regular physical activity for better long-term health outcomes after cancer.

Cited by 185 publications

References 36 publications

Lifestyle behaviors among US cancer survivors

Lifestyle behaviors among US cancer survivors

Quality of life in long-term and very long-term cancer survivors versus population controls in Germany

Attitudes, challenges and needs about diet and physical activity in endometrial cancer survivors: a qualitative study

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