The complex evaluation of tumor oxygen state and vasculature during preoperative chemotherapy in patients with breast cancer

Павлов, М. В.; Subochev, Pavel; Kalganova, Tatiana; Golubyatnikov, G. Yu.; Плеханов, В. И.; Ilyinskaya, O. E.; Orlova, Anna; Shakhova, Natalia M.; Maslennikova, Anna

doi:10.1117/12.2251419

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…In case the tumor is bigger than 4 cm, the mask may help to add new points required for scanning of the whole area of the tumor tissue. By means of MATLAB ® (MathWorks, Natick, Massachusetts), in each plane a percentage of the colored pixels number (equivalent to blood vessels) to the total pixel number of the image 52 [ Fig. 5(c)] was determined.…”

Section: Doppler Ultrasonic Imagingmentioning

confidence: 99%

Multimodal approach in assessment of the response of breast cancer to neoadjuvant chemotherapy

Павлов¹,

Kalganova

Lyubimtseva³

et al. 2018

J. Biomed. Opt.

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The ability for noninvasive visualization of functional changes of a tumor's oxygenation and circulatory system offers new advantages for prognosis and monitoring of the treatment efficacy. The results of breast cancer oxygen state study under chemotherapy action obtained by diffuse optical spectroscopy (DOS) in combination with Doppler ultrasonic imaging are presented. Complex use of optical and ultrasound methods gives complementary information about the size of the tumor node, peculiarities of its vascular bed, rate of its blood flow as well as oxygenation, and provide a picture of the tumor response to treatment. Comparison with tumor pathologic response allowed to identify differences in the changes of these parameters depending on the degree of pathological tumor response to chemotherapy. It was demonstrated that fourth and fifth degrees of therapeutic pathomorphism may be predicted by the increase of oxygen saturation level after the first cycle of chemotherapy. If the reduction or absence of the oxygen saturation dynamics is observed, first or second degree of pathological tumor response can be expected. Additional ultrasound investigation of the tumors may be useful for observation of the dynamics of tumor blood flow thereby for understanding the reasons of induced chemotherapy oxygenation changes. The proposed approach based on DOS and ultrasonography may be applied for monitoring of breast tumors under therapy and prediction of their sensitivity.

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Section: Doppler Ultrasonic Imagingmentioning

confidence: 99%

Multimodal approach in assessment of the response of breast cancer to neoadjuvant chemotherapy

Павлов¹,

Kalganova

Lyubimtseva³

et al. 2018

J. Biomed. Opt.

View full text Add to dashboard Cite

show abstract

“…Some patients who had large operable breast carcinomas can be downstaged after preoperative treatment so as to undergo breast conservative operation instead of mastectomy . Unfortunately, accurate assessment of tumor response after presurgical treatment remains a severe challenge since the existing medical examination techniques, such as magnetic resonance imaging or ultrasonography, still lack sufficient resolution . Lack of highly sensitive diagnosis tools makes breast carcinoma a disease difficult to select optimal treatment and avoid unnecessary treatment.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of breast carcinoma regression after preoperative chemotherapy by label‐free multiphoton imaging and image analysis

Zhou

Qiu

et al. 2019

Journal of Biophotonics

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Neoadjuvant chemotherapy is increasingly being used in breast carcinoma as it significantly improves the prognosis and consistently leads to an increased rate of breast preservation. How to accurately assess tumor response after treatment is a crucial factor for developing reasonable therapeutic strategy. In this study, we were in an attempt to monitor tumor response by multimodal multiphoton imaging including two‐photon excitation fluorescence and second‐harmonic generation imaging. We found that multiphoton imaging can identify different degrees of tumor response such as a slight, significant, or complete response and can detect morphological alteration associated with extracellular matrix during the progression of breast carcinoma following preoperative chemotherapy. Two quantitative optical biomarkers including tumor cellularity and collagen content were extracted based on automatic image analysis to help monitor changes in tumor and its microenvironment. Furthermore, tumor regression grade diagnosis was tried to evaluate by multiphoton microscopy. These results may offer a basic framework for using multiphoton microscopic imaging techniques as a helpful diagnostic tool for assessing breast carcinoma response after presurgical treatment.

show abstract

The complex evaluation of tumor oxygen state and vasculature during preoperative chemotherapy in patients with breast cancer

Cited by 2 publications

References 16 publications

Multimodal approach in assessment of the response of breast cancer to neoadjuvant chemotherapy

Multimodal approach in assessment of the response of breast cancer to neoadjuvant chemotherapy

Evaluation of breast carcinoma regression after preoperative chemotherapy by label‐free multiphoton imaging and image analysis

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