The complement system in teleosts

RNA-seq profiles from grass carp tissues after reovirus (GCRV) infection based on singular and modular enrichment analyses

“…The majority of complements are secreted by the liver in mammals, but it is different in fish as multiple organs are related to complement secretion. The complement cascade consists of three pathways: classical (Holland and Lambris, 2002), lectin and alternative pathways (Sakai, 1992). In our data, the enrichment of these three pathways was tissuespecific.…”

“…The complement system of teleost fish consists of three pathways, making it similar to of the system found in higher vertebrates (Boshra et al, 2004;Nonaka and Smith, 2000). Many complement proteins have been isolated from various teleost species (Holland and Lambris, 2002;Dodds and Petry, 1993;Endo et al, 1998;Yeo et al, 1997), and it has been suggested the complement system of fish may have wider recognition functions than in mammals (Sunyer and Tort, 1995) due to the larger diversity of complement proteins (Nakao et al, 2002).…”

“…In fact, fish occupy an apparent crossroads between the innate immune response and the evolution of the adaptive immune response (Tort et al, 2003). The immune system of teleosts is very similar to higher vertebrates, not at the level of organs but at the molecular level (Tort et al, 2003;Holland and Lambris, 2002). Some molecules related to adaptive immunity, such as IgM (Acton et al, 1971), IgD (Wilson et al, 1997) and CD8 (Fischer et al, 2006), were identified in fish decades ago.…”

Spontaneous haemolytic activity of rohu (Labeo rohita) serum

“…Like mammalian complement system, the fish complement system is activated through three pathways viz. classical pathway-the antibody dependent, alternative complement pathway-the antibody independent and, activated directly by foreign microorganisms and lectin pathway (8,9). All three pathways combine to form lytic pathway i.e., formation of membrane attack complex which leads to direct lysis of invading pathogens.…”

Serum bactericidal activity as indicator of innate immunity in pacu Piaractus mesopotamicus (Holmberg, 1887)

“…Vet. Zootec., v.65, n.6, p. [1745][1746][1747][1748][1749][1750][1751]2013 are responsible for detecting the pathogenic agent, and can be found in the cell membrane of T lymphocytes (TCR -T cell receptor) and B lymphocytes (BCR, B cell receptor, also called a membrane immunoglobulin) or in serum as free antibody (Holland and Lambris, 2002;Abbas and Litchman, 2004;Boltaña et al, 2011).…”