The competitive NMDA receptor antagonists CGP 37849 and CGP 39551 are potent, orally-active anticonvulsants in rodents

Schmutz, M.; Portet, Ch.; Jeker, A.; Klebs, K.; Vassout, A.; Allgeier, Hans; Heckendorn, Roland; Fagg, Graham E.; Olpe, Hans‐Rudolf; Riezen, H. van

doi:10.1007/bf00178973

Cited by 134 publications

(62 citation statements)

References 14 publications

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“…The methods described by Ngo Bum et al (2008) and Schmutz et al (1990) were adopted for this study with modifications. Thirty mice were divided into five groups of six.…”

Section: Picrotoxin-induced Seizures In Micementioning

confidence: 99%

“…Thirty minutes after treatment, 75 mg/kg of NMDA was administered to each mouse, s.c. Animals that did not elicit turning behavior within 30 min period were considered protected (Ngo Bum et al, 2008;Schmutz et al, 1990). Turning behavior was characterized by two consecutive 360 cycles by the same animal (Ngo Bum et al, 2008).…”

Section: Picrotoxin-induced Seizures In Micementioning

confidence: 99%

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Anticonvulsant activity of aqueous fraction ofCarissa edulisroot bark

Ya’u

Yaro

Malami

et al. 2015

Pharmaceutical Biology

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Context: Carissa edulis Vahl (Apocynaceae) is used in Nigerian folk medicine to manage a plethora of diseases including epilepsy, cancer, and inflammation; its efficacy is widely acclaimed among communities of northern Nigeria. Objective: This study establishes anticonvulsant activities of aqueous fraction of ethanol root bark extract of Carissa edulis (RAF) and sub-fractions (S1 and S2) in animal models. Materials and methods:We evaluated the acute toxicity of the RAF, S1 and S2, and the anticonvulsant activity using pentylenetetrazole (PTZ), picrotoxin, strychnine, N-methyl-Daspartate (NMDA), isoniazid (INH), and aminophylline-induced seizures in mice. Their effects on maximal electroshock (MES) and kindling-induced seizures were studied in chicks and in rats, respectively, and in the electrophysiological study. The doses used for RAF were 150, 300, and 600 mg/kg while S1 and S2 were 250, 500, and 1000 mg/kg. Both RAF and sub-fractions were administered once during the experiment. Results: The intraperitoneal LD 50 of the RAF was estimated to be 2222.61 mg/kg and that of the S1 and S2 were above 5000 mg/kg. RAF protected the mice by 50% while sub-fractions by 16.67% against PTZ-induced seizures. RAF offered 33.33 and 16.67% protection against strychnine and NMDA models, respectively. However, RAF offered 66.67-33.33% protections against aminophylline-induced seizures at doses of 150 and 600 mg/kg, but RAF, S1, and S2 had no effect on MES-induced seizures. Discussion and conclusion: Our results validate the use of the plant traditionally in the management of epilepsy, thus supporting the appraisal of biologically active components of this plant as antiepileptic agents.

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“…The methods described by Ngo Bum et al (2008) and Schmutz et al (1990) were adopted for this study with modifications. Thirty mice were divided into five groups of six.…”

Section: Picrotoxin-induced Seizures In Micementioning

confidence: 99%

Section: Picrotoxin-induced Seizures In Micementioning

confidence: 99%

Anticonvulsant activity of aqueous fraction ofCarissa edulisroot bark

Ya’u

Yaro

Malami

et al. 2015

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…Animals that did not exhibit turning behaviour within the 30 min of observation were declared protected. Turning behaviour was characterised by two consecutive 360° cycles fulfilled by the same animal (Croucher et al, 1982;Ngo Bum et al, 2001;2009a;2009b;Schmutz et al, 1990). …”

Section: Anticonvulsant Tests 241 N-methyl-d-aspartate (Nmda) Testmentioning

confidence: 99%

Antiepileptic Medicinal Plants used in Traditional Medicine to Treat Epilepsy

Bum¹,

Taïwé²,

Moto³

et al. 2011

Clinical and Genetic Aspects of Epilepsy

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“…Animals that did not exhibit turning behavior within the 30 min observation period were declared protected. Turning was characterized by two consecutive 360° cycles fulfilled by the same animal (Ngo Bum et al 2002;Schmutz et al, 1990). For the non-protected animals, the onset time of this behavior was recorded.…”

Section: N-methyl-d-aspartate (Nmda) Testmentioning

confidence: 99%

“…The method has been described previously (Ngo Bum et al 2001;Schmutz et al, 1990). Clonic seizures were induced in male mice by the i.p.…”

Section: Pentylenetetrazol (Ptz) Testmentioning

confidence: 99%

Sedative and anticonvulsant properties of <i>Passiflora edulis</i> dried leaves decoction in mice

Bum

Ngah

Ekoundi

et al. 2004

Afr. J. Trad. Compl. Alt. Med.

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Passiflora edulis Sims is native from Tropical area of South America. It is used in traditional medicine in the treatment of some diseases related to the nervous system and others. The extract of Passiflora edulis possesses sedative activity in mice. It significantly increased the total sleep time induced by diazepam (50 mg/kg i.p.). The total sleep time increased from 31 + 11 min in the control group to 77.6 + 15 and 78.3 + 16 min in the groups treated with extract at the doses of 132.5 and 1325 mg/kg respectively. This extract showed also anticonvulsant activity in mice. It protected mice against strychnine -induced seizures and antagonized N-methyl-D-aspartate-induced turning behavior in mice. The ED 50 for the protection against seizures -induced by strychnine was 320 mg/kg intraperitoneally (i.p.). For N-methyl-D-aspartate -induced turning behavior, the ED 50 was 300 mg/kg i.p. Passiflora edulis extract had less effect against pentylene tetrazol-induced seizures. The potentiation of diazepam-induced sleep, the antagonism of chemical -induced seizures and turning behavior suggest that Passiflora edulis extract possess sedative and anticonvulsant properties in animals.

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The competitive NMDA receptor antagonists CGP 37849 and CGP 39551 are potent, orally-active anticonvulsants in rodents

Cited by 134 publications

References 14 publications

Anticonvulsant activity of aqueous fraction ofCarissa edulisroot bark

Anticonvulsant activity of aqueous fraction ofCarissa edulisroot bark

Antiepileptic Medicinal Plants used in Traditional Medicine to Treat Epilepsy

Sedative and anticonvulsant properties of <i>Passiflora edulis</i> dried leaves decoction in mice

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