Antiepileptic Medicinal Plants used in Traditional Medicine to Treat Epilepsy

Bum, Elisabeth Ngo; Taïwé, Germain Sotoing; Moto, Fleur Clarisse Okomolo; Ngoupaye, Gwladys Temkou; Vougat, R.R.N.; Sakoue, V.D.; Gwa, C.; Ayissi, E.R.M.; Dong, Chriatian; Rakotonirina, A.; Rakotonirina, S.V.

doi:10.5772/18469

Cited by 12 publications

(5 citation statements)

References 45 publications

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“…While 9 plants are used for headaches, insomnia is treated with 10 plants, though 3 of them ( Artocarpus altilis, Morus mesozygia and Rhigiocarya racemifera ) are said to be too strong as a sedative, as such they are only used to sedate people suffering from mental disorder. Twenty (20) plants are used to treat convulsion and epilepsy and unsurprisingly 5 of the plants are Bidens pilosa, Bryophyllum pinnatum, Danielli oliveri, Khaya senegalensis and Tetrapleura tetraptera are also used in Cameroon for the same purpose [ 98 ] . The 5 medicinal plants were also shown to protect 50%–75% of tested mice against pentylenetetrazol (PTZ) and single-twitch-response (STR) induced convulsions [ 98 ].…”

Section: Resultsmentioning

confidence: 99%

“…Twenty (20) plants are used to treat convulsion and epilepsy and unsurprisingly 5 of the plants are Bidens pilosa, Bryophyllum pinnatum, Danielli oliveri, Khaya senegalensis and Tetrapleura tetraptera are also used in Cameroon for the same purpose [ 98 ] . The 5 medicinal plants were also shown to protect 50%–75% of tested mice against pentylenetetrazol (PTZ) and single-twitch-response (STR) induced convulsions [ 98 ]. Cooked fruits of Tetracarpidium conophorum are eaten to prevent giddiness.…”

Section: Resultsmentioning

confidence: 99%

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Wandering through southwestern Nigeria: An inventory of Yoruba useful angiosperm plants

Ajao

Mukaila

Sabiu

2022

Heliyon

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This paper is a compilation of all known uses of angiosperm plants by the Yoruba people of southwestern Nigeria. Information was gathered from the past experiences of authors and surveys of books, journal articles, dissertations (published and unpublished) and theses using online databases. The review presents 493 angiosperm species (65 monocots and 428 dicots) belonging to 99 families, of which Fabaceae contributed the highest number of useful plants (72 spp.), followed by Euphorbiaceae (31 spp.), Malvaceae (30 spp.), and Asteraceae (25 spp.). Generally, of the identified plants, 418 species are for medicinal purposes, 85 species are utilized as food and beverages, 65 species for other uses including games, food packaging, and arts and crafts while 22 species are used for magical purposes such as success charm, enhancing disappearance, protection from witches and escaping from the repercussion of an act. This study provides baseline ethnobotanical data for future quantitative analyses of useful plants in the region, as indigenous plant knowledge has not been properly explored and documented among the Yoruba people.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Wandering through southwestern Nigeria: An inventory of Yoruba useful angiosperm plants

Ajao

Mukaila

Sabiu

2022

Heliyon

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“…Some of these appear to modify lymphocyte function and consequently the immunological response. It is thought that the antiinflammatory effect is related to different mechanisms of action depending on the chemical structure, as the hydroxyl group binds to the gabergic receptors blocking the release of free radicals [12].…”

Section: Discussionmentioning

confidence: 99%

“…An episode of spasm lasting at least 5 s was considered to be the onset of tonicclonic convulsions. The mouse was said to be protected when it did not convulse within 10 min [12].…”

Section: Convulsion Induction Test With Pentylene Tetrazole (Ptz)mentioning

confidence: 99%

Evaluation of the Antioxidant Capacity and Studies of the Anticonvulsant Properties of Hymenocardia acida

Mathieu,

Lucie,

Omam

et al. 2024

JABB

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The work focuses on evaluating the antioxidant capacity and studying the anticonvulsant properties of the bark of Hymencardia acida (Euphorbiaceae), which is a tropical African plant traditionally used in the Centre Region of Cameroon in the treatment of many diseases such as migraines, diarrhoea, wounds, stomach ache and influenza. The various antioxidant tests carried out have highlighted the high antioxidant content of the bark of these plants. The results of the anticonvulsant activity showed that: The decoction of Hymencardia acida antagonized the convulsions induced by 100% pentylenetetrazole at doses of 22.5, 45 and 90 mg/kg. It also protected mice from convulsions induced by pilocarpine, 100% at doses 45 and 90 mg/kg and in the 4-aminopyridine convulsion induction test, it protected mice 100% at doses 45 and 90 mg/kg with a significant difference of (P ≤ 0.001) compared to the negative control. This study justify the use of H. acida in traditional medicine category 1, for the treatment of epilepsy in the community of the Centre Region of Cameroon.

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“…Its leaves are also being used empirically in traditional medicine in Cameroon to treat insomnia and muscle relaxant. (Bum et al, 2011) In Thailand M.…”

Section: Traditional Usementioning

confidence: 99%

Pharmacognostic specification and rosmarinic acid content of mentha cordifolia leaves and stems in Thailand

Chamnanthongpiwan¹

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Mentha cordifolia Opiz ex Fresen. is one of the popular Thai kitchen herbs due to its unique aroma and benefits to human health such as helping to relieve colds, fever, motion sickness and poor digestion problems. This study aimed to specify the quality parameters of M. cordifolia dried leaves and stems with special reference to rosmarinic acid (RA) contents. The pharmacognostic specifications of leaf and stem crude drugs were investigated including microscopic cross-sectioning of leaf and stem as well as leaf constant numbers; physico-chemical contents i.e. acid-insoluble ash, total ash, loss on drying, moisture, extractive matters and volatile oil. The chemical constituents of the volatile oil were analyzed by GC/MS. TLC fingerprints of these crude drugs were demonstrated. The ethanolic extracts were prepared exhaustively using Soxhlet apparatus. RA quantitative analysis was made by reverse phased high performance liquid chromatography (RP-HPLC) using intentsil® ODS-3 column as stationary phase and methanol: 0.2% phosphoric acid (45% : 55%) as mobile phase. The results demonstrated the anatomical characters of leaf and stem cross-sections. The stomata (diacytic type) were found in upper and lower sides of leaf. The microscopic leaf constant numbers were found to be as follows: upper stomatal index 2.85 ± 0.64, upper trichome index 045 ± 0.44, upper oil gland index 3.09 ± 0.89, upper epidermal cell area 2128.64 ± 182.80 µm2, palisade ratio 4.63 ± 0.35; lower stomatal index 19.95 ± 2.65, lower trichome index 0.46 ± 0.33, lower oil gland index 5.97 ± 1.75 and lower epidermal cell area 1793.52 ±262.45 µm2. The physico-chemical specification demonstrated the contents of acid-insoluble ash, total ash, loss on drying and moisture in leaf should not be more than 1.98, 9.41, 7.06 and 10.50 % by weight respectively; the ethanol-soluble extractive matter, water-soluble extractive matter and volatile oil in leaf should not be less than 5.04, 15.23 and 0.36 % by weight respectively. The main chemical compound in the volatile oil was piperitenone oxide (73.22%). The specification contents of acid-insoluble ash, total ash, loss on drying and moisture in stem should not be more than 1.63, 8.41, 7.04, 10.01 % by weight respectively; the ethanol-soluble extractive matter and water-soluble extractive matter in stem should not be less than 5.20 and 16.60 % by weight respectively. RP-HPLC analysis revealed the RA content in leaf as 1.92 ± 1.26 and in stem as 0.99 ± 0.41 g/100 g by dry weight.

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Antiepileptic Medicinal Plants used in Traditional Medicine to Treat Epilepsy

Cited by 12 publications

References 45 publications

Wandering through southwestern Nigeria: An inventory of Yoruba useful angiosperm plants

Wandering through southwestern Nigeria: An inventory of Yoruba useful angiosperm plants

Evaluation of the Antioxidant Capacity and Studies of the Anticonvulsant Properties of Hymenocardia acida

Pharmacognostic specification and rosmarinic acid content of mentha cordifolia leaves and stems in Thailand

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