The comparison of α-bromo-4-chlorocinnamaldehyde and cinnamaldehyde on coxsackie virus B3-induced myocarditis and their mechanisms

Ya, Zhang; Cao, Wei; Xie, Youhua; Yang, Qian; Li, Xiaoqiang; Liu, Xinxin; Wang, Siwang

doi:10.1016/j.intimp.2012.06.007

Cited by 24 publications

(18 citation statements)

References 42 publications

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“…Cinnamaldehyde inhibited phosphorylation of phospholipase Cγ1 (PLCγ1) [17] and ERK1/2 [18]. Not only cinnamaldehyde, also its derivatives have diverse biological activities [35][36][37][38][39][40]. In particular, phydroxycinnamic acid, 4-hydroxy-3-methoxycinnamaldehyde and α-bromo-4-chlorocinnamaldehyde have the immunomodulatory effects in mammalian cells [36,37,39].…”

Section: Discussionmentioning

confidence: 99%

“…Not only cinnamaldehyde, also its derivatives have diverse biological activities [35][36][37][38][39][40]. In particular, phydroxycinnamic acid, 4-hydroxy-3-methoxycinnamaldehyde and α-bromo-4-chlorocinnamaldehyde have the immunomodulatory effects in mammalian cells [36,37,39]. In coxsackie virus B3 (CVB3)-treated rat cardiomyocytes, α-bromo-4-chlorocinnamaldehyde inhibited the production of TNF-α, IL-1β and IL-6 via suppression of TLR4 expression and NF-κB activation [39].…”

Section: Discussionmentioning

confidence: 99%

“…In particular, phydroxycinnamic acid, 4-hydroxy-3-methoxycinnamaldehyde and α-bromo-4-chlorocinnamaldehyde have the immunomodulatory effects in mammalian cells [36,37,39]. In coxsackie virus B3 (CVB3)-treated rat cardiomyocytes, α-bromo-4-chlorocinnamaldehyde inhibited the production of TNF-α, IL-1β and IL-6 via suppression of TLR4 expression and NF-κB activation [39]. p-hydroxycinnamic acid [36] and 4-hydroxy-3-methoxycinnamaldehyde [37] attenuated anti-CD3/CD28 or PMA/ A23187 induced T cell activation via suppression of ERK1/2, p38 phosphorylation and NF-κB activation in Jurkat cells [36,37].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Cinnamaldehyde derivatives inhibit degranulation and inflammatory mediator production in rat basophilic leukemia cells

Ahn

Kim

Lee

et al. 2016

International Immunopharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cinnamaldehyde derivatives inhibit degranulation and inflammatory mediator production in rat basophilic leukemia cells

Ahn

Kim

Lee

et al. 2016

International Immunopharmacology

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“…These results suggested that compound 4 and 5 had potent anti-inflammatory activities. In addition, we observed that compound 5 inhibited CVB3-induced NF-κB activation, IκB-α degradation and phosphorylation by dose-dependent method, and decreased hearts’ Toll like receptor (TLR) 4 protein level (Zhang et al ., 2012). However, further studies involving structure-activity relationship are needed.…”

Section: Discussionmentioning

confidence: 99%

“…Cardiomyocytes culture and cytotoxicity assay were performed according to a previously described procedure (Zhang et al ., 2012). Briefly, rat cardiomyocytes were isolated from the ventricles of one to three-day-old Sprague-Dawley rats.…”

Section: Methodsmentioning

confidence: 99%

Cinnamaldehyde Derivatives Inhibit Coxsackievirus B3-Induced Viral Myocarditis

Li¹,

Liu²,

Xie³

et al. 2017

Biomolecules & Therapeutics

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The chemical property of cinnamaldehyde is unstable in vivo, although early experiments have shown its obvious therapeutic effects on viral myocarditis (VMC). To overcome this problem, we used cinnamaldehyde as a leading compound to synthesize derivatives. Five derivatives of cinnamaldehyde were synthesized: 4-methylcinnamaldehyde (1), 4-chlorocinnamaldehyde (2), 4-methoxycinnamaldehyde (3), α-bromo-4-methylcinnamaldehyde (4), and α-bromo-4-chlorocinnamaldehyde (5). Neonatal rat cardiomyocytes and HeLa cells infected by coxsackievirus B3 (CVB3) were used to evaluate their antiviral and cytotoxic effects. In vivo BALB/c mice were infected with CVB3 for establishing VMC models. Among the derivatives, compound 4 and 5 inhibited the CVB3 in HeLa cells with the half-maximal inhibitory concentrations values of 11.38 ± 2.22 μM and 2.12 ± 0.37 μM, respectively. The 50% toxic concentrations of compound 4 and 5-treated cells were 39-fold and 87-fold higher than in the cinnamaldehyde group. Compound 4 and 5 effectively reduced the viral titers and cardiac pathological changes in a dose-dependent manner. In addition, compound 4 and 5 significantly inhibited the secretion, mRNA and protein expressions of inflammatory cytokines TNF-α, IL-1β and IL-6 in CVB3-infected cardiomyocytes, indicating that brominated cinnamaldehyde not only improved the anti-vital activities for VMC, but also had potent anti-inflammatory effects in cardiomyocytes induced by CVB3.

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Simultaneous determination of cinnamaldehyde and its metabolite in rat tissues by gas chromatography–mass spectrometry

Zhao

Yang

Xie

et al. 2014

Biomedical Chromatography

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Cinnamaldehyde (CA), an active ingredient isolated from the traditional Chinese medicine Cortex Cinnamomi, has a wide range of bioactivities. To clarify the distribution characteristics of CA, a selective and sensitive method utilizing gas chromatography-mass spetrometry was initially developed for simultaneously determining the concentration of CA and its metabolite cinnamyl alcohol in rat tissues. Selected ion masses of m/z 131, 105 and 92 were chosen, and separation of the analytes was performed on a DB-5 ms (30 m × 0.25 mm, 0.25 µm, thickness) capillary column by gas chromatography-mass spectrometry. The calibration curves demonstrated good linearity and reproducibility over the range of 20-2000 and 20-4000 ng/mL for various tissue samples. Recoveries ranged from 86.8 to 107.5%, while intra- and interday relative standard deviations were all <11.3%. The analysis method was successfully applied in tissue distribution studies for CA and cinnamyl alcohol. As CA and cinnamyl alcohol may inter-convert to one another, simultaneous determination of both analytes provides a comparative and accurate data for tissue study. The concentrations of CA and cinnamyl alcohol remaining in spleen were the highest among the main organs, including heart, liver, spleen, lung, kidney and brain. In addition, there was no long-term accumulation of CA in rat tissues.

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The comparison of α-bromo-4-chlorocinnamaldehyde and cinnamaldehyde on coxsackie virus B3-induced myocarditis and their mechanisms

Cited by 24 publications

References 42 publications

Cinnamaldehyde derivatives inhibit degranulation and inflammatory mediator production in rat basophilic leukemia cells

Cinnamaldehyde derivatives inhibit degranulation and inflammatory mediator production in rat basophilic leukemia cells

Cinnamaldehyde Derivatives Inhibit Coxsackievirus B3-Induced Viral Myocarditis

Simultaneous determination of cinnamaldehyde and its metabolite in rat tissues by gas chromatography–mass spectrometry

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