Cinnamaldehyde derivatives inhibit degranulation and inflammatory mediator production in rat basophilic leukemia cells

Ahn, Sungyong; Kim, Eun‐Hee; Lee, Kooyeon; Lee, Deug‐Chan

doi:10.1016/j.intimp.2016.06.018

Cited by 14 publications

(11 citation statements)

References 56 publications

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“…Our data are in accordance with recent publications showing that CE and its major mediator CA prevented degranulation as well as de novo synthesis of inflammatory mediators in human mast cells isolated from intestinal tissue and in rat basophilic leukaemia cells . Additionally, following oral or intranasal treatment of mice with CE, a significantly decreased expression of mast cell‐specific proteases and a reduced production of total IgE and histamine levels have been reported .…”

Section: Discussionsupporting

confidence: 93%

“…Cinnamon extract (CE) derived from the dried bark of the tropical evergreen tree Cinnamomum verum and its major compound trans ‐cinnamaldehyde (CA) have been reported to possess anti‐oxidant, anti‐microbial, anti‐inflammatory, anti‐diabetic, anti‐cancer, cardioprotective and beneficial effects in arthritis, arteriosclerosis and Alzheimer's disease . Moreover, it has been demonstrated that CE and CA also exert anti‐allergic properties by decreasing release and expression of mast cell‐specific mediators . In a randomized double‐blind placebo‐controlled clinical trial, patients with seasonal allergic rhinitis were treated with ClearGuard ™ tablets, containing a combination of cinnamon, acerola and Spanish needles, resulting in a reduced nasal symptom score after nasal allergen challenge and inhibited prostaglandin D2 release into nasal lavage fluid .…”

Section: Introductionmentioning

confidence: 99%

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Cinnamon extract inhibits allergen‐specific immune responses in human and murine allergy models

Ose

Schink

et al. 2019

Clin Experimental Allergy

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Background Ceylon cinnamon has been shown to possess anti‐inflammatory properties in many diseases including allergic inflammation. Objective The aim of this study was to analyse in more detail the effects of cinnamon extract (CE) and its major compounds p‐cymene and trans‐cinnamaldehyde (CA) on allergen‐specific immune responses in vitro and in vivo. Methods Therefore, monocyte‐derived mature dendritic cells (DC) from grass or birch pollen allergic donors were pulsed with the respective allergen in the presence or absence of CE, p‐cymene, CA or the solvent ethanol and co‐cultured with autologous CD4+ T cells. Furthermore, basophil activation test was performed with or without CE or ethanol treatment. For the in vivo experiments, BALB/c mice were immunized with ovalbumin (OVA) and orally treated with CE or ethanol. Results Addition of CE, p‐cymene or CA, but not ethanol significantly inhibited DC maturation and subsequent allergen‐specific T cell proliferation as well as Th1 and Th2 cytokine production. Sulphidoleukotriene release and CD63 expression by basophils were also significantly diminished after addition of CE. In vivo, treatment of OVA‐sensitized mice with CE led to a significant shift from OVA‐specific IgE towards IgG2a production and to a strong inhibition of OVA‐specific proliferation. Moreover, airway inflammation as well as anaphylaxis after intranasal or systemic allergen challenge was significantly reduced in CE‐treated mice. Furthermore, topical application of CE prevented calcipotriol‐induced atopic dermatitis‐like inflammation in these mice. Conclusions and Clinical Relevance Taken together, our data indicate that the anti‐inflammatory effect of cinnamon might be exploited for treatment of allergic inflammation, which needs to be further investigated.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Cinnamon extract inhibits allergen‐specific immune responses in human and murine allergy models

Ose

Schink

et al. 2019

Clin Experimental Allergy

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“…Both the mRNA and protein levels of p38, ERK, CXCL-8, and COX 2 were downregulated. Similar findings were documented [56] using cinnamon extracts and their derivatives. Suppressing the p38 and ERK pathways suggests that their regulatory roles in allergic inflammation could be modified by CA.…”

Section: Discussionsupporting

confidence: 85%

Anti-Allergic Potential of Cinnamaldehyde via the Inhibitory Effect of Histidine Decarboxylase (HDC) Producing Klebsiella pneumonia

et al. 2020

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Allergy is an immunological disorder that develops in response to exposure to an allergen, and histamines mediate these effects via histidine decarboxylase (HDC) activity at the intracellular level. In the present study, we developed a 3D model of Klebsiella pneumoniae histidine decarboxylase (HDC) and analyzed the HDC inhibitory potential of cinnamaldehyde (CA) and subsequent anti-allergic potential using a bacterial and mammalian mast cell model. A computational and in vitro study using K. pneumonia revealed that CA binds to HDC nearby the pyridoxal-5′-phosphate (PLP) binding site and inhibited histamine synthesis in a bacterial model. Further study using a mammalian mast cell model also showed that CA decreased the levels of histamine in the stimulated RBL-2H3 cell line and attenuated the release of β-hexoseaminidase and cell degranulation. In addition, CA treatment also significantly suppressed the levels of pro-inflammatory cytokines TNF-α and IL-6 and the nitric oxide (NO) level in the stimulated mast cells. A gene expression and Western blotting study revealed that CA significantly downregulated the expressions of MAPKp38/ERK and its downstream pro-allergic mediators that are involved in the signaling pathway in mast cell cytokine synthesis. This study further confirms that CA has the potential to attenuate mast cell activation by inhibiting HDC and modifying the process of allergic disorders.

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“…Therefore, the release of β-hexosaminidase is widely used as an indicator of the degranulation of MCs. 20 For this reason, experimental evidence has postulated that cinnamon reduced the degranulation of MCs, thereby regulating histamine synthesis. 21 It is thought that cinnamon plays an essential role in the intracellular mobilization of Ca ++ ions in mucosal MCs with its inhibitory effects on the phospholipase C signaling pathway.…”

Section: Groupsmentioning

confidence: 99%

Effect of Cinnamon on Distribution and Number of Mast Cells in Diabetic Rat Liver

Ertuğrul¹,

ERTUĞRUL²

2022

Turkiye Klinikleri J Vet Sci

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Diabetes mellitus (DM) is a severe metabolic disorder with numerous functional and structural consequences. 1 The chronic high glucose level in the blood is a disorder caused by the inability of the pancreas's beta cells (β cells) to produce enough insulin or the use of ineffective insulin by the cells in the body. 2 Cinnamon is a spice that exhibits economic and medicinal value and finds use in traditional medicine. Antimicrobial, antitumor, antioxidant, anti-diabetic, anti-inflammatory, and analgesic properties are among its biological activities. 3 Cinnamon promotes the expression of insulin-sensitive glucose transporters, resulting in decreased insulin resistance. 4

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Cinnamaldehyde derivatives inhibit degranulation and inflammatory mediator production in rat basophilic leukemia cells

Cited by 14 publications

References 56 publications

Cinnamon extract inhibits allergen‐specific immune responses in human and murine allergy models

Cinnamon extract inhibits allergen‐specific immune responses in human and murine allergy models

Anti-Allergic Potential of Cinnamaldehyde via the Inhibitory Effect of Histidine Decarboxylase (HDC) Producing Klebsiella pneumonia

Effect of Cinnamon on Distribution and Number of Mast Cells in Diabetic Rat Liver

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